全文获取类型
收费全文 | 92657篇 |
免费 | 3095篇 |
国内免费 | 2582篇 |
专业分类
化学 | 35129篇 |
晶体学 | 957篇 |
力学 | 7562篇 |
综合类 | 152篇 |
数学 | 33678篇 |
物理学 | 20856篇 |
出版年
2024年 | 42篇 |
2023年 | 322篇 |
2022年 | 578篇 |
2021年 | 620篇 |
2020年 | 660篇 |
2019年 | 731篇 |
2018年 | 10862篇 |
2017年 | 10685篇 |
2016年 | 6761篇 |
2015年 | 1656篇 |
2014年 | 1255篇 |
2013年 | 1484篇 |
2012年 | 5145篇 |
2011年 | 11798篇 |
2010年 | 6579篇 |
2009年 | 6998篇 |
2008年 | 7558篇 |
2007年 | 9554篇 |
2006年 | 1028篇 |
2005年 | 1960篇 |
2004年 | 2076篇 |
2003年 | 2410篇 |
2002年 | 1510篇 |
2001年 | 636篇 |
2000年 | 613篇 |
1999年 | 493篇 |
1998年 | 457篇 |
1997年 | 376篇 |
1996年 | 412篇 |
1995年 | 299篇 |
1994年 | 228篇 |
1993年 | 250篇 |
1992年 | 155篇 |
1991年 | 163篇 |
1990年 | 134篇 |
1989年 | 139篇 |
1988年 | 129篇 |
1987年 | 98篇 |
1986年 | 96篇 |
1985年 | 93篇 |
1984年 | 70篇 |
1983年 | 54篇 |
1982年 | 65篇 |
1981年 | 49篇 |
1980年 | 49篇 |
1979年 | 51篇 |
1914年 | 45篇 |
1912年 | 40篇 |
1909年 | 41篇 |
1908年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
921.
Robert M. Smith Ping Yuan David P. Weiner Caryn R. Dutton David E. Hansen 《Applied biochemistry and biotechnology》1994,47(2-3):329-343
We describe here a novel strategy for the isolation of antibodies with sequence-specific protease activity: the synthesis
of dipeptide haptens in which the targeted peptide bond has been replaced by a ring-strained or torsionally strained hydroxyethylene
transition-state analog. Thus, the analogs mimic both a peptide bond in a distorted, reactive conformation and the transition
state for peptide bond hydrolysis. In order to obtain sequence-specific antibody proteases, these analogs have been flanked
with additional amino acid residues in preparation for immunization. In particular, we have synthesized peptides containing
analogs such as 2-cis-amino-3-cis-hydroxycyclobutane carboxylic acid andendo-(3-amino-2-hydroxy)bicyclo[2.2.1]heptane-7-anti-carboxylic acid. We have also prepared a series of peptide derivatives containing
analogs, such as 2-[3-amino-2-oxo-1-azetidinyl]-3-methylbutanoic acid, in which the targeted peptide bond has been incorporated
into a β-lactam ring. Since the “peptide bond” has been left intact, these species mimic only a distorted ground state. At
present, antibodies are being elicited against a number of the above peptide derivatives. 相似文献
922.
The synthesis and anion binding properties of new ruthenium(II) and cobalt(II) phenanthroline complexes, containing two amide
subunits are described. Evidence for anion binding in dimethyl sulfoxide (DMSO) solution was obtained from u.v.–vis titration
experiments. Results indicated that these receptors showed strong affinity for F− and AcO−, and showed weak affinity for OH− and H2PO
4
−
, and showed no affinity for Cl−, Br−, I−. These receptors interacted with various anions examined through hydrogen-bond formation. 相似文献
923.
M. Blaauw I. H. Degenaar J. J. M. de Goeij 《Journal of Radioanalytical and Nuclear Chemistry》2007,271(3):765-770
In order to correct for neutron self-shielding in large-sample prompt gamma NAA, a method has been developed to determine
the macroscopic scattering and absorption cross sections, i.e., Σ
a and Σ
s, using four Cu flux monitors placed around the sample. With Monte Carlo computations, the neutron densities throughout the
sample and the resulting and the corresponding self-shielding factor as calculated from the Σ
a and Σ
s as obtained through the Cu monitors were compared to the true values. The derived Σ
a and Σ
s were found to be sufficiently accurate as long as Σ
t = Σ
a + Σ
s was less than 0.6 cm−1 and Σ
s/Σ
t was greater than 0.1. 相似文献
924.
采用温和条件下的溶胶-凝胶技术,成功制备了阴离子交换-反相混合模式硅胶基质毛细管电色谱整体柱。通过调整反应液中不同前体的比例,优化了整体柱的制备条件。通过扫瞄电镜,对柱床进行了表征和分析。实验发现,所制备的整体柱电渗流的方向和大小可随流动相pH值的改变而改变,在酸性和中性条件下,具有从阴极流向阳极的电渗流;当流动相pH值升至约7.5时,电渗流方向发生了反转(由阳极流向阴极)。在优化的实验条件下,用所制备的整体柱对所考察的酸性(中性)化合物实现了快速分离,并获得了高达160,000N/m的柱效。 相似文献
925.
Novel thermoreversible physical hydrogels formed from polymers with linear and star architectures possessing a linear poly(ethyleneimine) (PEI) backbone have been investigated. The hydrogelation occurred simply upon natural cooling of hot aqueous solutions of PEIs to room temperature. The X-ray diffraction and differential scanning calorimetry measurements for the resultant hydrogels unambiguously indicated that the hydrogelation originated from the formation of dihydrate crystalline structures of PEI. These crystalline hydrogels are structurally unique and hierarchical. Microscopic images revealed that the morphologies of the crystalline hydrogels depend on their molecular architectures. The linear PEI resulted in branched fibrous bundles organized by unit crystalline nanofibers with a width of ca. 5-7 nm. The six-armed star with benzene ring core produced fanlike fibrous bundles while the four-armed star with porphyrin core assembled into asterlike aggregates. The critical concentration of gelation (C(G)) was low (about 0.2 approximately 0.3%) and the thermoreversible gel-sol transition temperatures (T(G)) were controllable from approximately 43 to approximately 79 degrees C. The hydrogels formed in the presence of the various aqueous additives including organic solvents, hydrophilic polymers, physical cross-linker, chemical cross-linker, and base enabling modification and functionalization during synthesis. The mechanical properties of the hydrogels could be improved by chemical cross-linking of preformed hydrogels by glutaraldehyde. Physically and physical/chemical cross-linked hydrogels served as excellent template roles in biomimetic silicification, which produced silica-PEI hybrid powder or monolith constructed by nanofibers. 相似文献
926.
Cyril Prknyi Hui Liang Yuan Bo H. E. Strmberg Ariella Evenzahav 《Journal of heterocyclic chemistry》1992,29(4):749-753
The synthesis of ten new substituted 1,3,4-thiadiazolyl-4(3H)-quinazolinones 8–11, 13, 17 , and 20–23 is reported. Compounds 8–11 were prepared by condensation of 5-fluoro-2-methyl-3,1-benzoxazin-4-one (3) and 5-substituted 2-amino-1,3,4-thiadiazoles 4–7. Compound 13 was obtained by condensation of 5-fluoro-2-methyl-3,1-benzoxazin-4-one (3) with DL-α-amino-?-caprolactam (12) . Compound 17 was synthesized by condensation of 6-bromo-2-methyl-3,1-benzoxazin-4-one (16) and 2-amino-5-t-butyl-1,3,4-thiadiazole (5) . Compounds 20–23 were obtained by condensation of 5-chloro-6,8-dibromo-2-methyl-3,1-benzoxazin-4-one (19) and 5-substituted 2-amino-1,3,4-thiadiazoles 4–7, respectively. The substituted 3,1-benzoxazin-4-ones 3, 16, and 19 were obtained in good yield by refluxing the appropriate anthranilic acid, 1,15 , and 18 with acetic anhydride (2) . 相似文献
927.
928.
“Simple” energetic patterns, where simple means the use of parameters derived only from the stoichiometry of these species,
are relatively rarely discussed in the literature. In addition, entropy studies have been dominated by derivation of the absolute
quantity S° rather than the entropy of formation (TΔf
S
o). Relationships between the entropy of formation and different parameters such as negative value of the charge of the species,
the number of oxygen atoms, the natural logarithm of the molecular weight, the total number of atoms and the number of central
atoms that are gases were recently discussed by us for aqueous polynuclear oxyanions. As shown here hydrogen containing anions
do not follow this pattern. In this study, new approaches for the estimation of the entropy of formation of aqueous hydrogen
containing mono and polynuclear oxyanions are suggested, evaluated and recommended. 相似文献
929.
Pei Yuan Wu 《Integral Equations and Operator Theory》1984,7(6):899-904
If T is a contraction on the Hilbert space H and there is an invariant subspace K for T such that T/K is similar to a backward shift, then T is reflexive. If similarity is replaced by quasi-similarity, then the same conclusion holds under the additional condition that the defect index of T be finite.This research was partially supported by National Science Council (Republic of China). 相似文献
930.
Dragan Mihailovic 《Monatshefte für Chemie / Chemical Monthly》2003,134(2):137-147
Ferromagnetism in fullerene-based systems doped with metallocenes is reviewed. These compounds form a ferromagnetic state
by spin-coupling between π electrons on fullerene units, while the metallocene molecules do not contribute to the spin ordering.
One of these compounds has the highest critical temperature (19 K) for this class of compound. The magnetic properties of
these materials are very strongly dependent on the crystallization conditions.
Corresponding author. E-mail: Dragan.Mihailovic@ijs.si
Received September 4, 2002; accepted September 6, 2002 相似文献