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81.
Background
When eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. Activated Gcn2p up-regulates the general amino acid control pathway through phosphorylation of the translational initiation factor eIF2. In Saccharomyces cerevisiae, Gcn2p is the only kinase that phosphorylates eIF2 to regulate translation through this mechanism. We addressed changes in yeast growth and tRNA aminoacylation, or charging, during amino acid depletion in the presence and absence of GCN2. tRNA charging was measured using a microarray technique which simultaneously measures all cytosolic tRNAs. A fully prototrophic strain, and its isogenic gcn2Δ counterpart, were used to study depletion for each of the 20 amino acids, with a focus on Trp, Arg, His and Leu, which are metabolically distinct and together provide a good overview on amino acid metabolism. 相似文献82.
偏分复用系统信道串扰的理论模型及消除方案 总被引:2,自引:0,他引:2
建立了偏分复用(PDM)系统中信道串扰的数学模型,并提出了消除该串扰的方案,即用解复用端一路光信号的射频(RF)功率作为反馈信号以监测光信号在链路中偏振态的变化和在接收端的串扰情况,用粒子群优化(PSO)算法作为逻辑控制单元的算法,控制偏振控制器以消除信道间的串扰。数值仿真了RF功率与信道串扰大小之间的关系,并在2×50Gb/s偏分复用-差分正交移相键控(PDM-DQPSK)传输系统平台上仿真验证了消除串扰方案的效果。结果表明该方案能够大幅降低系统误码率,改善系统性能。 相似文献
83.
Based on a mathematical model of laser beams, we present a spectral Galerkin method for solving a Cauchy problem of the Helmholtz equation in a rectangle, where the Cauchy data pairs are given at y?=?0 and boundary data are for x?=?0 and x?=?π. The solution is sought in the interval 0?<?y?<?1. The spectral Galerkin method is considered as a regularization method. We then perform an analysis on the error bound for this method. For illustration, several numerical experiments are constructed to demonstrate the feasibility and efficiency of the proposed method. 相似文献
84.
86.
Xiaoxia Lv Xue Xue Xingyu Gan Chenhao Lv Xiaochen Sun Yun Wang Liangjun Li Hua Wang 《化学:亚洲杂志》2020,15(3):432-439
High‐performance non‐noble electrocatalysts for oxygen reduction reaction (ORR) are the prerequisite for large‐scale utilization of fuel cells. Herein, a type of sandwiched‐like non‐noble electrocatalyst with highly dispersed FeNx active sites embedded in a hierarchically porous carbon/graphene heterostructure was fabricated using a bottom‐up strategy. The in situ ion substitution of Fe3+ in a nitrogen‐containing MOF (ZIF‐8) allows the Fe‐heteroatoms to be uniformly distributed in the MOF precursor, and the assembly of Fe‐doped ZIF‐8 nano‐crystals with graphene‐oxide and in situ reduction of graphene‐oxide afford a sandwiched‐like Fe‐doped ZIF‐8/graphene heterostructure. This type of heterostructure enables simultaneous optimization of FeNx active sites, architecture and interface properties for obtaining an electron‐catalyst after a one‐step carbonization. The synergistic effect of these factors render the resulting catalysts with excellent ORR activities. The half‐wave potential of 0.88 V vs. RHE outperforms most of the none‐noble metal catalyst and is comparable with the commercial Pt/C (20 wt %) catalyst. Apart from the high activity, this catalyst exhibits excellent durability and good methanol‐tolerance. Detailed investigations demonstrate that a moderate content of Fe dopants can effectively increase the intrinsic activities, and the hybridization of graphene can enhance the reaction kinetics of ORR. The strategy proposed in this work gives an inspiration towards developing efficient noble‐metal‐free electrocatalysts for ORR. 相似文献
87.
88.
1,3-Dipolar cycloaddition reactions of nitrones with α,β-unsaturated aldehydes catalyzed by a cationic chiral dirhodium(II,III) carboxamidate with (R)-menthyl (S)-2-oxopyrrolidine-5-carboxylate ligands in toluene increase reaction rates, give optimum regioselectivities, and enhance stereoselectivities compared to the same reactions performed in traditionally used halocarbon solvents. Rate and enantioselectivity enhancements were also obtained in hetero-Diels-Alder and carbonyl-ene reactions performed in toluene over those obtained in dichloromethane using the diastereomeric chiral cationic dirhodium(II,III) carboxamidate with (S)-menthyl (S)-2-oxopyrrolidine-5-carboxylate ligands. These enhancements are attributed to diminished or absent association of toluene with the catalyst which lessens the relative importance of the uncatalyzed background reaction, and they may also be a consequence of different coordination angles for aldehyde association with rhodium in the different solvent environments. Overall, the enhancement of reaction rates and selectivities with cationic chiral dirhodium(II,III) carboxamidates in toluene suggests broad applications for them in Lewis acid catalyzed reactions. 相似文献
89.
Xiaochen Yang Hui Miao Ruotong Xiao Luyao Wang Yan Zhao Qifan Wu Yanli Ji Juanjuan Du Hongqiang Qin Weimin Xuan 《Chemical science》2021,12(28):9778
Site-specific modification of proteins has significantly advanced the use of proteins in biological research and therapeutics development. Among various strategies aimed at this end, genetic code expansion (GCE) allows structurally and functionally distinct non-canonical amino acids (ncAAs) to be incorporated into specific sites of a protein. Herein, we genetically encode an esterified glutamic acid analogue (BnE) into proteins, and demonstrate that BnE can be applied in different types of site-specific protein modifications, including N-terminal pyroglutamation, caging Glu in the active site of a toxic protein, and endowing proteins with metal chelator hydroxamic acid and versatile reactive handle acyl hydrazide. Importantly, novel epigenetic mark Gln methylation is generated on histones via the derived acyl hydrazide handle. This work provides useful and unique tools to modify proteins at specific Glu or Gln residues, and complements the toolbox of GCE.Herein, we genetically encode an esterified glutamic acid analogue (BnE) into proteins, and demonstrate that BnE can be applied in different types of site-specific protein modifications. 相似文献
90.
Xiaochen Wang Hao Luo Yeping Sun Maojie Zhang Xiaoyu Li Gui Yu Yunqi Liu Yongfang Li Haiqiao Wang 《Journal of polymer science. Part A, Polymer chemistry》2012,50(2):371-377
A novel fused ladder alternating D–A copolymer, PIDT–DPP, with alkyl substituted indacenodithiophene (IDT) as donor unit and diketopyrrolopyrrole (DPP) as acceptor unit, was designed and synthesized by Pd‐catalyzed Stille‐coupling method. The copolymer showed good solubility and film‐forming ability combining with good thermal stability. PIDT–DPP exhibited a broad absorption band from 350 to 900 nm with an absorption peak centered at 735 nm. The optical band gap determined from the onset of absorption of the polymer film was 1.37 eV. The highest occupied molecular orbital level of the polymer is as deep as ?5.32 eV. The solution‐processed organic field‐effect transistor (OFETs) was fabricated with bottom gate/top contact geometry. The highest FET hole mobility of PIDT–DPP reached 0.065 cm2 V?1 s?1 with an on/off ratio of 4.6 × 105. This mobility is one of the highest values for narrow band gap conjugated polymers. The power conversion efficiency of the polymer solar cell based on the polymer as donor was 1.76% with a high open circuit voltage of 0.88 V. To the best of our knowledge, this is the first report on the photovoltaic properties of alkyl substituted IDT‐based polymers. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 相似文献