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排序方式: 共有165条查询结果,搜索用时 15 毫秒
121.
Eliott Le Du Thibaut Duhail Dr. Matthew D. Wodrich Dr. Rosario Scopelliti Dr. Farzaneh Fadaei-Tirani Dr. Elsa Anselmi Dr. Emmanuel Magnier Prof. Dr. Jerome Waser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(42):10979-10986
Ethynylbenziodoxol(on)e (EBX) cyclic hypervalent iodine reagents have become popular reagents for the alkynylation of radicals and nucleophiles, but only offer limited possibilities for further structure and reactivity fine-tuning. Herein, the synthesis of new N-heterocyclic hypervalent iodine reagents with increased structural flexibility based on amide, amidine and sulfoximine scaffolds is reported. Solid-state structures of the reagents are reported and the analysis of the I−Calkyne bond lengths allowed assessing the trans-effect of the different substituents. Molecular electrostatic potential (MEP) maps of the reagents, derived from DFT computations, revealed less pronounced σ-hole regions for sulfonamide-based compounds. Most reagents reacted well in the alkynylation of β-ketoesters. The alkynylation of thiols afforded more variable yields, with compounds with a stronger σ-hole reacting better. In metal-mediated transformations, the N-heterocyclic hypervalent iodine reagents gave inferior results when compared to the O-based EBX reagents. 相似文献
122.
An efficient postsynthesis method of guanidination of oligonucleotides was employed to introduce several guanidinium groups into internucleotide phosphoramidate linkages. The amino functions of aminobutylphosphoramidate links were converted to guanidine butylphosphoramidates using a solution of O-methylisourea hemisulfate in aqueous ammonia, in a short reaction time. The synthesis of various fully guanidylated oligonucleotides was successfully performed to provide a new class of cationic phosphoramidate oligonucleotides. 相似文献
123.
A straightforward route toward 2-(hetero)arylated and 2,5-di(hetero)arylated oxazoles through regiocontrolled palladium-catalyzed direct (hetero)arylation of ethyl oxazole-4-carboxylate with iodo-, bromo-, and chloro(hetero)aromatics followed by a two-step hydrolysis/decarboxylation sequence was described. The method was applied here to a neat synthesis of two 2,5-di(hetero)aryloxazole natural products, balsoxin and texaline. 相似文献
124.
Inside Cover: Active Esters as Pseudostoppers for Slippage Synthesis of [2]Pseudorotaxane Building Blocks: A Straightforward Route to Multi‐Interlocked Molecular Machines (Chem. Eur. J. 26/2016) 下载免费PDF全文
125.
Vignon SA Jarrosson T Iijima T Tseng HR Sanders JK Stoddart JF 《Journal of the American Chemical Society》2004,126(32):9884-9885
Two switchable neutral bistable [2]rotaxanes have been synthesized, and their chemically induced mechanical switching has been studied in solution by 1H NMR spectroscopy. One of the rotaxanes was prepared by a thermodynamically controlled slippage mechanism, while the other rotaxane was obtained by a dynamic covalent chemistry protocol involving the assembly of its dumbbell component by olefin metathesis. The recognition sites present in the rod section of the dumbbell component, namely, naphthodiimide (NpI) and pyromellitic diimide (PmI) residues, were chosen in the knowledge that the ring component, 1,5-dinaphtho[38]crown-10 (1/5DNP38C10), will bind preferentially to the NpI site. However, upon introduction of Li+ ions into the solution, a 1:2 complex is formed between the PmI site, encircled by the 1/5DNP38C10 ring and two Li+ ions. Since this complex is more stable overall than the binding between the 1/5DNP38C10 ring and the NpI site, the ring component moves from the NpI site to the PmI one. This mechanical movement can be reversed by adding an excess of [12]crown-4 to the solution to act as a sequestering agent for the Li+ ions. 相似文献
126.
Forestier T Mornet S Daro N Nishihara T Mouri S Tanaka K Fouché O Freysz E Létard JF 《Chemical communications (Cambridge, England)》2008,(36):4327-4329
We report the synthesis of spin crossover 69 nm spherical nanoparticles of [Fe(NH(2)-trz)(3)](Br)(2).3H(2)O.0.03(surfactant) (NH(2)trz = 4-amino-1,2,4-triazole, surfactant = Lauropal), prepared by the reverse micelle technique, which exhibit at room temperature a thermal hysteresis characterized by magnetic, diffuse reflectivity and Raman studies. 相似文献
127.
The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-butyl 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4-thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-butyl sulfomycinamate thio-analogue from tert-butyl 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence. 相似文献
128.
129.
Thibaut Stoll Dr. Marcello Gennari Dr. Isabel Serrano Dr. Jérôme Fortage Dr. Jérôme Chauvin Dr. Fabrice Odobel Dr. Mateusz Rebarz Dr. Olivier Poizat Dr. Michel Sliwa Dr. Alain Deronzier Dr. Marie‐Noëlle Collomb 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(2):782-792
We report a very efficient homogeneous system for the visible‐light‐driven hydrogen production in pure aqueous solution at room temperature. This comprises [RhIII(dmbpy)2Cl2]Cl ( 1 ) as catalyst, [Ru(bpy)3]Cl2 ( PS1 ) as photosensitizer, and ascorbate as sacrificial electron donor. Comparative studies in aqueous solutions also performed with other known rhodium catalysts, or with an iridium photosensitizer, show that 1) the PS1 / 1 /ascorbate/ascorbic acid system is by far the most active rhodium‐based homogeneous photocatalytic system for hydrogen production in a purely aqueous medium when compared to the previously reported rhodium catalysts, Na3[RhI(dpm)3Cl] and [RhIII(bpy)Cp*(H2O)]SO4 and 2) the system is less efficient when [IrIII(ppy)2(bpy)]Cl ( PS2 ) is used as photosensitizer. Because catalyst 1 is the most efficient rhodium‐based H2‐evolving catalyst in water, the performance limits of this complex were further investigated by varying the PS1 / 1 ratio at pH 4.0. Under optimal conditions, the system gives up to 1010 turnovers versus the catalyst with an initial turnover frequency as high as 857 TON h?1. Nanosecond transient absorption spectroscopy measurements show that the initial step of the photocatalytic H2‐evolution mechanism is a reductive quenching of the PS1 excited state by ascorbate, leading to the reduced form of PS1 , which is then able to reduce [RhIII(dmbpy)2Cl2]+ to [RhI(dmbpy)2]+. This reduced species can react with protons to yield the hydride [RhIII(H)(dmbpy)2(H2O)]2+, which is the key intermediate for the H2 production. 相似文献
130.