Novel Template Sorbents for Separation of Americium(III) from Nitric Acid Solutions: Search of Optimal Ion‐Imitator of AmIII

A series of new template sorbents that enable selective and effective sorption of Am^III from 0.5 to 4M HNO₃ solutions containing high concentrations of Fe^III and Zr^IV was synthesized from (ethenyl)(diphenyl)phosphine oxide. La^III, Ce^III, and Pr^III were used as template elements imitating the properties of Am^III. The highest efficiency of separation of Am^III from high amounts of Fe^III and Zr^IV was displayed by the Ce^III‐based sorbent.     

Delay-induced bifurcations in collocated position control of an elastic arm

The interference of the elasticity of a single robotic arm and the unavoidable time delay of its position control is analysed from nonlinear vibrations viewpoint. The simplified mechanical model of two blocks and a connecting spring considers the first vibration mode of the arm, while the collocated proportional-derivative (PD) control uses the state of the first block only and actuates also there. It is assumed that the relevant nonlinearity is the saturation of the delayed control force. The linear stability analysis proves that stabilizable and non-stabilizable parameter regions follow each other periodically even for large spring stiffnesses and for tiny time delays. Hopf bifurcation calculation is carried out after an infinite-dimensional centre manifold reduction, and closed-form algebraic expressions are given for the amplitudes of the emerging oscillations. These results support the experimental tuning of the control gains since the parameters of the arising and often unexpected self-excited vibrations can serve as a guide for this practical procedure.

     

Structural and optical characterization of colloidal Se nanoparticles prepared via the acidic decomposition of sodium selenosulfate

Colloidal selenium nanoparticles (NPs) were synthesized via acidic decomposition of sodium selenosulfate. The effects of synthesis and post-synthesis treatment conditions on the size, structure and size distribution of the Se nanoparticles are discussed. It is shown that the decomposition of sodium selenosulfate with non-oxidative acids (e.g., HCl) in aqueous solutions of polymers (sodium polyphosphate, gelatin, polyvinyl alcohol, polyethyleneglycole) and surfactants (sodium dodecylsulfonate, cetylpyridinium chloride) results in the formation of amorphous 25–200 nm Se nanoparticles converting upon ageing at 90 °C into trigonal 150–250 nm Se nanocrystals. Optical properties (absorption and Raman spectra) of freshly prepared and aged Se nanoparticles both in colloidal solutions and in polymeric (polyvinyl alcohol) films are analyzed.     

Synthesis,Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones as Possible Anticancer Agents

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-b][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-b][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of Z/E-isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-b]-[1,2,4]triazole-6-ones. The compounds have been studied for their antitumor activity in the NCI 60 lines screen. Some compounds present excellent anticancer properties at 10 μM. Derivatives 2h and 2i were the most active against cancer cell lines without causing toxicity to normal somatic (HEK293) cells. A preliminary SAR study had been performed for the synthesized compounds.     

69mZn-containing radiopharmaceuticals: a novel approach to molecular design

^69mZn was produced and separated for medical applications. Possibilities and perspectives for production of radiopharmaceuticals based on ^69mZn containing derivatives of thiazine, thiazoline and thiourea are considered. Each one of the latters is a zinc chelator and a nitric oxide synthase (NOS) effector at the same time. Cytotoxic effect of NOS activator and NOS inhibitors are shown in experiments with HL-60, K-562 and MOLT-4 cell lines and in bone marrow cells of the acute B-lymphoblastic leukemia patients. Some of those compounds are worthy to get selected for further application as radiopharmaceuticals including their antitumor speciements.

     

Analysis of cardiovascular oscillations: a new approach to the early prediction of pre-eclampsia

Pre-eclampsia (PE) is a serious disorder with high morbidity and mortality occurring during pregnancy; 3%-5% of all pregnant women are affected. Early prediction is still insufficient in clinical practice. Although most pre-eclamptic patients show pathological uterine perfusion in the second trimester, this parameter has a positive predictive accuracy of only 30%, which makes it unsuitable for early, reliable prediction. The study is based on the hypothesis that alterations in cardiovascular regulatory behavior can be used to predict PE. Ninety-six pregnant women in whom Doppler investigation detected perfusion disorders of the uterine arteries were included in the study. Twenty-four of these pregnant women developed PE after the 30th week of gestation. During pregnancy, additional several noninvasive continuous blood pressure recordings were made over 30 min under resting conditions by means of a finger cuff. The time series extracted of systolic as well as diastolic beat-to-beat pressures and the heart rate were studied by variability and coupling analysis to find predictive factors preceding genesis of the disease. In the period between the 18th and 26th weeks of pregnancy, three special variability and baroreflex parameters were able to predict PE several weeks before clinical manifestation. Discriminant function analysis of these parameters was able to predict PE with a sensitivity and specificity of 87.5% and a positive predictive value of 70%. The combined clinical assessment of uterine perfusion and cardiovascular variability demonstrates the best current prediction several weeks before clinical manifestation of PE.