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991.
Rosaria Cozzolino Sadrollah Ramezani Antonella Martignetti Angela Mari Sonia Piacente Beatrice De Giulio 《Natural product research》2016,30(7):841-848
Salvia spp. are used throughout the world both for food and pharmaceutical purposes. In this study, a method involving headspace solid-phase microextraction combined with gas chromatography–mass spectrometry was developed, to establish the volatiles profile of dried leaves of four Iranian Salvia spp.: Salvia officinalis L., Salvia leriifolia Benth, Salvia macrosiphon Boiss. and two ecotypes of Salvia reuterana Boiss. A total of 95 volatiles were identified from the dried leaves of the five selected samples. Specifically, α-thujone was the main component of S. officinalis L. and S. macrosiphon Boiss. (34.40 and 17.84%, respectively) dried leaves, S. leriifolia Benth was dominated by β-pinene (27.03%), whereas α-terpinene was the major constituent of the two ecotypes of S. reuterana Boiss. (21.67 and 13.84%, respectively). These results suggested that the proposed method can be considered as a reliable technique for isolating volatiles from aromatic plants, and for plant differentiation based on the volatile metabolomic profile. 相似文献
992.
Léa Falcoz-Vigne Yu Ogawa Sonia Molina-Boisseau Yoshiharu Nishiyama Valérie Meyer Michel Petit-Conil Karim Mazeau Laurent Heux 《Cellulose (London, England)》2017,24(9):3725-3739
The successive extraction and re-adsorption of a linear β-(1 → 4) xylan extracted from microfibrillated birch pulp was investigated using solid-state CP/MAS 13C NMR spectroscopy, specific surface area measurements, and atomistic molecular dynamics (MD) simulations. The NMR spectra confirmed that when in contact with cellulose after re-adsorption, the xylan molecules altered their conformation from the classical left-handed threefold structure found in the bulk to a different one, presumably a cellulose-like twofold system for quantities up to the equivalent amount of extracted xylan. Combining these observations with specific surface area measurements and the surface occupied by a xylosyl residue, it was possible to show that the re-adsorbed xylan in the modified conformation occurred only within the first adsorbed layer in direct interaction with the cellulose surface. It is only when an excess xylan was added and after full cellulose surface coverage, that the subsequent deposited layers took the classical threefold organization. Following the variation of xylan conformation in terms of sequential xylan addition allowed quantifying the surface of cellulose accessible for a tight adsorption of xylan, not only for microfibrillated birch cellulose, but for other samples as well. The MD simulations confirmed that xylan in threefold conformation had a weaker affinity for the cellulose surface than its twofold counterpart, thus supporting the hypothesis of the twofold conformation for xylan at the cellulose surface. The MD simulations also showed that in contact with cellulose, the adsorbed xylan was mainly organized as an extended molecular chain aligned parallel to the cellulose chain direction. 相似文献
993.
Sinenhlanhla X. H. Mthembu Phiwayinkosi V. Dludla Khanyisani Ziqubu Tawanda M. Nyambuya Abidemi P. Kappo Evelyn Madoroba Thembeka A. Nyawo Bongani B. Nkambule Sonia Silvestri Christo J. F. Muller Sithandiwe E. Mazibuko-Mbeje 《Molecules (Basel, Switzerland)》2021,26(9)
Polyphenols are naturally derived compounds that are increasingly being explored for their various health benefits. In fact, foods that are rich in polyphenols have become an attractive source of nutrition and a potential therapeutic strategy to alleviate the untoward effects of metabolic disorders. The last decade has seen a rapid increase in studies reporting on the bioactive properties of polyphenols against metabolic complications, especially in preclinical models. Various experimental models involving cell cultures exposed to lipid overload and rodents on high fat diet have been used to investigate the ameliorative effects of various polyphenols against metabolic anomalies. Here, we systematically searched and included literature reporting on the impact of polyphenols against metabolic function, particularly through the modulation of mitochondrial bioenergetics within the skeletal muscle. This is of interest since the skeletal muscle is rich in mitochondria and remains one of the main sites of energy homeostasis. Notably, increased substrate availability is consistent with impaired mitochondrial function and enhanced oxidative stress in preclinical models of metabolic disease. This explains the general interest in exploring the antioxidant properties of polyphenols and their ability to improve mitochondrial function. The current review aimed at understanding how these compounds modulate mitochondrial bioenergetics to improve metabolic function in preclinical models on metabolic disease. 相似文献
994.
Sonia Burgaz Concepcin García María Gmez-Caas Alain Rolland Eduardo Muoz Javier Fernndez-Ruiz 《Molecules (Basel, Switzerland)》2021,26(11)
The 3-hydroxyquinone derivative of the non-psychotrophic phytocannabinoid cannabigerol, so-called VCE-003.2, and some other derivatives have been recently investigated for neuroprotective properties in experimental models of Parkinson’s disease (PD) in mice. The pharmacological effects in those models were related to the activity on the peroxisome proliferator-activated receptor-γ (PPAR-γ) and possibly other pathways. In the present study, we investigated VCE-004.8 (formulated as EHP-101 for oral administration), the 3-hydroxyquinone derivative of cannabidiol (CBD), with agonist activity at the cannabinoid receptor type-2 (CB2) receptor in addition to its activity at the PPAR-γ receptor. Studies were conducted in both in vivo (lesioned-mice) and in vitro (SH-SY5Y cells) models using the classic parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). Our data confirmed that the treatment with VCE-004.8 partially reduced the loss of tyrosine hydroxylase (TH)-positive neurons measured in the substantia nigra of 6-OHDA-lesioned mice, in parallel with an almost complete reversal of the astroglial (GFAP) and microglial (CD68) reactivity occurring in this structure. Such neuroprotective effects attenuated the motor deficiencies shown by 6-OHDA-lesioned mice in the cylinder rearing test, but not in the pole test. Next, we explored the mechanism involved in the beneficial effect of VCE-004.8 in vivo, by analyzing cell survival in cultured SH-SY5Y cells exposed to 6-OHDA. We found an important cytoprotective effect of VCE-004.8 at a concentration of 10 µM, which was completely reversed by the addition of antagonists, T0070907 and SR144528, aimed at blocking PPAR-γ and CB2 receptors, respectively. The treatment with T0070907 alone only caused a partial reversal, whereas SR144528 alone had no effect, indicating a major contribution of PPAR-γ receptors in the cytoprotective effect of VCE-004.8 at 10 µM. In summary, our data confirmed the neuroprotective potential of VCE-004.8 in 6-OHDA-lesioned mice, and in vitro studies confirmed a greater relevance for PPAR-γ receptors rather than CB2 receptors in these effects. 相似文献
995.
Arunprasad Veeranan Siva Karthik P. Thulasi Selvam Arul G. P. Shkir Mohd. Rajamanickam A. T. Sumathi T. Fredrick Sonia R. 《Journal of Cluster Science》2022,33(6):2651-2659
Journal of Cluster Science - A facile one step synthetic hydrothermal route was used to fabricate the Pt free Ni3S4/CoS2 heterostructure counter electrode and study the photovoltaic characteristics... 相似文献
996.
Sonia Aviles-Sacoto Wade D Cook Raha Imanirad Joe Zhu 《The Journal of the Operational Research Society》2015,66(11):1868-1877
This paper investigates efficiency measurement in a two-stage data envelopment analysis (DEA) setting. Since 1978, DEA literature has witnessed the expansion of the original concept to encompass a wide range of theoretical and applied research areas. One such area is network DEA, and in particular two-stage DEA. In the conventional closed serial system, the only role played by the outputs from Stage 1 is to behave as inputs to Stage 2. The current paper examines a variation of that system. In particular, we consider settings where the set of final outputs comprises not only those that result from Stage 2, but can include, in addition, certain outputs from the previous (first) stage. The difficulty that this situation creates is that such outputs are attempting to play both an input and output role in the same stage. We develop a DEA-based methodology that is designed to handle what we term ‘time-staged outputs’. We then examine an application of this concept where the DMUs are schools of business. 相似文献
997.
The potential of a crude peroxidase (POD) from onion solid waste as a biocatalyst for the synthesis of a naturally occurring aurone is described. The crude enzyme preparation effectively promotes the cyclization of 2′,3,4,4′,6′-pentahydroxy-chalcone (which is not a natural substrate of onion POD) into aureusidin. 相似文献
998.
999.
1000.
Giuseppina Orlandini Sonia Bacca Nir Barnea Winfried Leidemann 《Few-Body Systems》2013,54(7-10):1361-1365
The transition form factor to the 0+ resonance of 4He at 20.10 MeV is studied using different realistic potential models. A large dependence on these models is found. The results are compared to experimental data. The Lorentz integral transform (LIT) approach has allowed the separation of resonance and background contributions. 相似文献