Synthesis,anti‐bacterial,anti‐asthmatic and anti‐diabetic activities of novel N‐substituted‐2‐(benzo[d]isoxazol‐3‐ylmethyl)‐1H‐benzimidazoles

Synthesis of a series of novel class of N‐substituted‐2‐(benzo[d]isoxazol‐3‐ylmethyl)‐1H‐benzimidazoles ( 4 ) by the condensation of o‐phenylenediamine ( 1 ) with benzo[d]isoxazol‐3‐yl‐acetic acid ( 2 ) and subsequent reactions with different types of electrophiles have been reported. Some compounds exhibited promising anti‐bacterial activity against Salmonella typhimurium, however poor activity against Staphylococcus aureus. The compound 4t was found to have high activity even at 1 μg/ml compared to Cephalexin against S. aureus. The biological activity against PDE‐IV for potential anti‐asthmatic effect and against DP‐IV and PTP‐1B for potential anti‐diabetic effects was disappointing.     

I–V characteristics and break down studies of Sb2O3 structures

I–V characteristics of sandwiched Al–Sb₂O₃–Al structures have been studied for different thicknesses. The current-voltage curves in general exhibit three regions, ohmic, non ohmic and breakdown regions. The breakdown voltage increases whereas the dielectric strength decreases with increase in Sb₂O₃ film thickness. The electrical breakdown studies have been done for dc and ac voltages and optical photomicrographs of breakdown patterns during different stages of voltage have been taken and the results are explained.     

Rotation implementation of a circular cylinder in incompressible flow via staggered grid approach

In this paper, we present a finite difference method for the implementation of the rotation of a circular cylinder in the incompressible flow field by solving the two-dimensional unsteady Navier-Stokes equations. The approach is to use staggered grid method so that the accuracy and order of convergence of the associated algorithms can be maintained. The proposed method is easy to be implemented and is effective. A set of simulations for the flow dynamics is provided to show the computational results.     

Implicit large eddy simulation using the high‐order correction procedure via reconstruction scheme

We investigate implicit large eddy simulation of the Taylor–Green vortex, Comte‐Bellot–Corrsin experiment, turbulent channel flow and transitional and turbulent flow over an SD7003 airfoil using the high‐order unstructured correction procedure via reconstruction (CPR) scheme, also known as the flux reconstruction scheme. We employ P1 (second‐order) to P5 (sixth‐order) spatial discretizations. Results show that the CPR scheme can accurately predict turbulent flows without the addition of a sub‐grid scale model. Numerical dissipation, concentrated at the smallest resolved scales, is found to filter high‐frequency content from the solution. In addition, the high‐order schemes are found to be more accurate than the low‐order schemes on a per degree of freedom basis for the canonical test cases we consider. These results motivate the further investigation and use of the CPR scheme for simulating turbulent flows. Copyright © 2016 John Wiley & Sons, Ltd.     

Copper-catalyzed one-pot process to construct triazole-linked urea derivatives

A new one-pot synthetic methodology has been developed to construct the triazole-linked urea derivatives. In the same step, triazole forms from azide and alkyne via click reaction and urea forms from addition reaction of amines and isocyanates. The notable features of this work include wide substrate scope, atom economy, environmental friendliness, and easily accessible starting materials. The preliminary biological screening of synthesized compounds show promising cytotoxic activity in basal cell carcinoma (BCC) cell lines.     

Purification of 89Sr source obtained from 89Y(n,p) 89Sr by ion-exchange chromatography using tri-sodium tri-meta phosphate (SMP) as eluant

⁸⁹Sr was produced via ⁸⁹Y(n, p) ⁸⁹Sr using yttria as target in Fast Breeder Test Reactor (FBTR), Kalpakkam, India. A radiochemical procedure has been developed for the separation of bulk yttrium using TBP by solvent extraction followed by purification of ⁸⁹Sr source by ion exchange chromatography using the cation exchange resin Dowex 50WX8 (100–200 mesh) and nitric acid of variable molarity as eluant. The present study establishes the purification of ⁸⁹Sr source from the other radionuclidic impurities like ⁸⁸Y, ⁶⁵Zn, ⁵⁴Mn, ⁶⁰Co, ⁸⁶Rb, ¹⁹²Ir, ¹⁰³Ru, ¹¹³Sn, ¹³⁹Ce, ¹⁶⁰Tb, ¹⁵⁴Eu etc. produced during the irradiation of yttria by using the complexing agent tri-sodium tri-meta phosphate (SMP) in nitric acid medium instead of nitric acid alone as an eluant. The purification was achieved by using 0.1 M SMP as complexing agent which was optimized based on the distribution ratio data and final elution of Sr fraction was obtained in nitric acid medium. This resulted into a faster purification of ⁸⁹Sr source in a smaller volume of eluant. Purity of Sr source from the cross contamination of the complexing agent SMP was also ensured.     

Photoinduced electron transfer between anionic fluorophores and methyl viologen in homogeneous and microheterogeneous media

The rate and extent of photoinduced electron transfer change significantly as a result of confinement in nanovolumes. Study of such processes is an active area of research in physical chemistry. The effect is most interesting when the molecules that participate in PET are charged. In the present article, the modulation of PET has been studied for two anionic fluorophores: Lucifer Yellow CH and chlorin p₆ with Methylviologen dication. PET, manifested in the quenching of fluorescence of the fluorophores, has been modulated by incorporating the molecules in organized assemblies like micelles, reverse micelles and supramolecular hosts. The dynamics of the process has been monitored in the femtosecond to nanosecond timescale. The modulation of the electron transfer has been found to be occurring mainly due to the disruption of contact ion pairs formed between the fluorophores and the quencher.     

Total synthesis of cryptopyranmoscatone B1 from 3,4,6-tri-O-acetyl-d-glucal

The first stereoselective total synthesis of the natural cryptopyranmoscatone B1 has been accomplished from 3,4,6-tri-O-acetyl-d-glucal. In addition to the double cross-metathesis reaction, a tandem nucleophilic addition-diastereoselective reduction of an in situ generated oxocarbenium cation have been used as key steps to assemble the glycoside moiety of the target molecule.     

Optical absorption near infrared and EPR studies of mottramite

Mottramite mineral from Tsumeb Corporation Mine, Tsumeb, Otavi, Namibia, is investigated in this present work. The mineral contains vanadium and copper contents of 22.73% and 16.84% by weight, respectively, as V₂O₅ and CuO. An electron paramagnetic resonance (EPR) study confirmed the presence of Cu(II) with g = 2.2. The optical absorption spectrum of mottramite indicates that Cu(II) is present in a rhombic environment. Near infrared results are due to water fundamentals.