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11.
Marc N. Agnew Victor J. Bauer Richard C. Effland 《Journal of heterocyclic chemistry》1980,17(7):1573-1575
Using several N-methyl pyrazole analogs the utility of 13C nmr in determining isomeric structures was examined. The chemical shift assignments of the pyrazole carbons and thus the isomeric structures were determined using a combination of proton coupled and proton decoupled 13C nmr spectra. 相似文献
12.
A. H. Jay W. W. Stevenson E. W. Colbeck S. W. Craven W. Murray N. T. Wilkinson W. J. Agnew R. Treje C. Benedicks G. A. Medwedewa W. P. Remin F. Willems J. J. Berzelius Ed. Houdremont P. Klinger G. Blaschczyk P. Klineer und W. Koch 《Fresenius' Journal of Analytical Chemistry》1944,127(1):43-46
Ohne Zusammenfassung 相似文献
13.
Rohde RD Agnew HD Yeo WS Bailey RC Heath JR 《Journal of the American Chemical Society》2006,128(29):9518-9525
A general method for the non-oxidative functionalization of single-crystal silicon(111) surfaces is described. The silicon surface is fully acetylenylated using two-step chlorination/alkylation chemistry. A benzoquinone-masked primary amine is attached to this surface via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition ("click" chemistry). The benzoquinone is electrochemically reduced, resulting in quantitative cleavage of the molecule and exposing the amine terminus. Molecules presenting a carboxylic acid have been immobilized to the exposed amine sites. X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), and contact angle goniometry were utilized to characterize and quantitate each step in the functionalization process. This work represents a strategy for providing a general platform that can incorporate organic and biological molecules on Si(111) with minimal oxidation of the silicon surface. 相似文献
14.
MA Freitas SR Dillon RC Dougherty AG Marshall 《Rapid communications in mass spectrometry : RCM》1999,13(15):1622-1625
The self-chemical ionization of diethylzinc is examined by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry and semiempirical molecular orbital calculations. Electron impact of diethylzinc neutral produces the radical cation, C(4)H(15)Zn(+) (m/z x 122), which reacts further with the neutral (C(2)H(5))(2)Zn to give the following product ions: Zn(+) (m/z x 64), C(2)H(5)Zn(+) (m/z x 93), C(4)H(9)Zn(+) (m/z x 121), C(4)H(11)Zn(2)(+) (m/z x 187), and C(6)H(15)Zn(2)(+) (m/z x 215). To determine the structure and pathways for production of these ions, monoisotopic (12)C(4)H(15)(64)Zn(+), (64)Zn(+) and (12)C(2)H(5)(64)Zn(+) were individually isolated and reacted with the neutral background. We also performed semiempirical molecular orbital calculations (ZINDO/1). The molecular orbital calculations and experimental data are consistent in predicting that the ethyl group on the diethylzinc cation carries the positive charge. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
15.
W. J. Agnew W. Böttger F. Feigl J. M. Kolthoff L. Michaelis S. Yamaguchi A. Martini L. Rosenthaler J. Kapulitzas F. Fröhnke R. Nakaseko Matsuy G. Denigès A. Benedetti-Pichler F. Schneider Hilde Thurnwald L. de Brouckère E. Belcke E. W. Schwartze R. M. Hann J. H. Yoe W. L. Hill J. L. Steenkamp K. Heller P. Krumholz R. Montequi W. H. Hammond R. Ripan G. Lode Fr. Hecht und W. Reich-Rohrwig 《Fresenius' Journal of Analytical Chemistry》1932,88(3-4):128-136
Ohne Zusammenfassung 相似文献
16.
W. J. Agnew W. Böttger F. Feigl J. M. Kolthoff L. Michaelis S. Yamaguchi A. Martini L. Rosenthaler J. Kapulitzas F. Fröhnke R. Nakaseko Matsuy G. Denigès A. Benedetti-Pichler F. Schneider Hilde Thurnwald L. de Brouckère E. Belcke E. W. Schwartze R. M. Hann J. H. Yoe W. L. Hill J. L. Steenkamp K. Heller P. Krumholz R. Montequi W. H. Hammond R. Ripan G. Lode Fr. Hecht W. Reich-Rohrwig 《Analytical and bioanalytical chemistry》1932,88(3-4):128-136
17.
18.
Millward SW Henning RK Kwong GA Pitram S Agnew HD Deyle KM Nag A Hein J Lee SS Lim J Pfeilsticker JA Sharpless KB Heath JR 《Journal of the American Chemical Society》2011,133(45):18280-18288
We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays. Each peptide module in the branched structure makes unique contributions to affinity and/or specificity resulting in a 200 nM affinity ligand that efficiently immunoprecipitates Akt from cancer cell lysates and labels Akt in fixed cells. Our use of a small molecule to preinhibit Akt prior to screening resulted in low micromolar inhibitory potency and an allosteric mode of inhibition, which is evidenced through a series of competitive enzyme kinetic assays. To demonstrate the efficiency and selectivity of the protein-templated in situ click reaction, we developed a novel QPCR-based methodology that enabled a quantitative assessment of its yield. These results point to the potential for iterative in situ click chemistry to generate potent, synthetically accessible antibody replacements with novel inhibitory properties. 相似文献
19.
Dr. Samir Das Dr. Arundhati Nag JingXin Liang Dr. David N. Bunck Dr. Aiko Umeda Blake Farrow Matthew B. Coppock Deborah A. Sarkes Amethist S. Finch Heather D. Agnew Suresh Pitram Bert Lai Mary Beth Yu Dr. A. Katrine Museth Dr. Kaycie M. Deyle Bianca Lepe Frances P. Rodriguez‐Rivera Amy McCarthy Belen Alvarez‐Villalonga Ann Chen John Heath Dimitra N. Stratis‐Cullum Prof. James R. Heath 《Angewandte Chemie (International ed. in English)》2015,54(45):13219-13224
We describe a general synthetic strategy for developing high‐affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid. This synthetic epitope (SynEp) is incubated with a library of complementary alkyne or azide presenting peptides. Library elements that bind the SynEp in the correct orientation undergo the Huisgen cycloaddition, and are covalently linked to the SynEp. Hit peptides are tested against the full‐length protein to identify the best binder. We describe development of epitope‐targeted linear or macrocycle peptide ligands against 12 different diagnostic or therapeutic analytes. The general epitope targeting capability for these low molecular weight synthetic ligands enables a range of therapeutic and diagnostic applications, similar to those of monoclonal antibodies. 相似文献
20.
Crystals of the trans-octahedral complex Co(4-Vpy)4(NCS)2 on being heated below the melting point decompose with liberation of 4-vinylpyridine (Vpy) and concurrent polymerization of the free monomer. The two reactions have been followed by differential scanning calorimetry, thermogravimetry, and optical microscopy. Polymerization is inhibited by inclusion of hydroquinone during recrystallization of the complex. This has allowed the kinetic analysis of the decomposition and polymerization to be simplified. Isothermal mass-loss determinations under reduced pressure (10?2 torr), at various temperatures in the range 120–160°C, on hydroquinone-inhibited crystals corresponded to the loss of up to three molecules of vinylpyridine per molecule of starting complex. With uninhibited crystals over the same temperature range the total number of ligands lost was approximately two with a marked decrease near 175°C owing to rapid polymerization. Isothermal decomposition curves for inhibited and uninhibited crystals approximated to the Avrami-Erofeev equation. Values of n varied with temperature. Activation energies for decomposition and polymerization for both types of crystal were estimated from Arrhenius plots. 相似文献