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881.
882.
Kazuo Sakai Ryosuke Katsumi Hiroshi Ohi Taichi Usui Yoshiharu Ishido 《Journal of carbohydrate chemistry》2013,32(5):553-565
Abstract A β-D-galactosidase from Bacillus circulans induced β-D-galactopyranosyl transfer from lactose predominantly to a secondary (OH-4) rather than the primary hydroxyl group (OH-6) of 2-acetamido-2-deoxy-D-glucopyranose. 4-O-β-D-Galacto-pyranosyl-2-acetamido-2-deoxy-D-glucopyranose (N-acetyl-lactosamine) was thus readily synthesized on a gram scale and conveniently isolated by chromatography on a column of charcoal-Celite. On the other hand, the glycosyl transfer to the 6-position predominantly was efficiently induced to give 6-O-β-D-galactopyranosyl-2-acetamido-2-deoxy-D-glucopyranose (N-acetyl-allolactosamine) by consecutive use of β-D-galactosidases from Kluyveromyces lactis and B. circulans. These enzyme reactions were efficient enough to allow the one-pot preparation of the desired disaccharides. 相似文献
883.
Nakamura R Kakeya K Furuta N Muta E Nishisaka H Mizutani T 《The Journal of organic chemistry》2011,76(15):6108-6115
Coupled oxidation of [tetraarylporphyrinato]iron(III) chloride carrying substituents in the ortho or para positions was performed by allowing the iron porphyrin to react with dioxygen, ascorbic acid, and pyridine to give biladienone as the major product and bilindione as a minor one. Efforts to find reaction conditions and workup procedures to obtain bilindione improved the yields of triarylbilindiones ranging between 2% and 19%. Electron-withdrawing substituents in the para position on the aryl groups increased the selectivity of bilindione relative to biladienone: the isolated yields of bilindione and biladienone were 2% and 85% (OMe), 6% and 44% (COOMe), and 7% and 28% (CN), respectively. Electronic effects of substituents affected both isolation procedures and the spectroscopic properties of bilindiones. Tri(4-methoxyphenyl)bilindione showed a red-shifted electronic absorption compared to unsubstituted and 4-methoxycarbonyl substituted analogues. This was ascribed to the destabilization of the HOMO-1 level by the methoxy groups. 相似文献
884.
Four classes of benzylidene acetal type bridged nucleic acids (BA-BNAs) were designed with 2',4'-bridged structures that cleaved upon exposure to appropriate external stimuli. Cleavage of 6-nitroveratrylidene and 2-nitrobenzylidene acetal type BNA bridges occurred upon photoirradiation and subsequent treatment with thiol caused changes in secondary structure to afford 4'-C-hydroxymethyl RNA. Benzylidene and 4-nitrobenzylidene acetal type BNA responded to acids and reducing agents, respectively, resulting in hydrolysis of the acetal-bridged structure. Cleavage of the bridge removed sugar conformational restrictions and changed the duplex- and triplex-forming properties of the BNA-modified oligonucleotides. Moreover, oligonucleotides incorporating a single BA-BNA modification had considerably improved stability toward 3'-exonuclease, which was lost upon cleavage of the bridge. Thus, these new BNAs may be useful as therapeutic and detection tools by sensing various environments. 相似文献
885.
Abstract
Producing refuse-derived fuel (RDF) is one of the most effective measures of refuse treatment. However, RDF often consists of high level of lead. To reduce lead emission during combustion, understanding of lead behaviors in flames is required. In this study, we have applied planar laser-induced fluorescence spectroscopy to detect lead not only in a non-luminous methane–air flame, but also in a luminous RDF flame. In a methane–air flame, the number density of Pb atoms does not depend on the flame temperature, but also on the combustion environments. In RDF flames, because of acceleration of oxidizing process of Pb, Pb fluorescence profile obtained at 25% O2 became weaker than that at 20% O2. 相似文献886.
Very light gravitino scenario m3/2?16 eV is very interesting, since there is no cosmological problem. However in such a scenario, stability of the vacuum is an important issue. Recently, Yonekura and one of the authors RS have investigated the parameter space of a low scale gauge mediation with a perturbatively stable vacuum and found that there are severe upper bounds on the gaugino masses. In this Letter, we show that such a model can be completely excluded/discovered at very early stage of the LHC run. 相似文献
887.
Satoshi Nakagawa Isman Kurniawan Koichi Kodama Muhammad Saleh Arwansyah Kazutomo Kawaguchi 《Molecular physics》2018,116(5-6):666-677
ABSTRACTWe present a simple coarse-grained model with the molecular crowding effect in solvent to investigate the structure and dynamics of protein complexes including association and/or dissociation processes and investigate some physical properties such as the structure and the reaction rate from the viewpoint of the hydrophobic intermolecular interactions of protein complex. In the present coarse-grained model, a function depending upon the density of hydrophobic amino acid residues in a binding area of the complex is introduced, and the function involves the molecular crowding effect for the intermolecular interactions of hydrophobic amino acid residues between proteins. We propose a hydrophobic intermolecular potential energy between proteins by using the density-dependent function. The present coarse-grained model is applied to the complex of cytochrome f and plastocyanin by using the Langevin dynamics simulation to investigate some physical properties such as the complex structure, the electron transfer reaction rate constant from plastocyanin to cytochrome f and so on. We find that for proceeding the electron transfer reaction, the distance between metals in their active sites is necessary within about 18 Å. We discuss some typical complex structures formed in the present simulation in relation to the molecular crowding effect on hydrophobic interactions. 相似文献
888.
Shiro Kobayashi Hidekazu Morii Ryosuke Ito Masashi Ohmae 《Macromolecular Symposia》2002,183(1):127-132
Artificial hyaluronic acid has been synthesized in vitro via enzymatic polymerization catalyzed by testicular hyaluronidases, which is the first successful example of the hyaluronic acid synthesis via non-biosynthetic pathways. The novel GlcAβ(1→3)GlcNAc oxazoline derivative was designed and synthesized as a transition state analogue monomer for the hyaluronidase catalysis. The oxazoline monomer was efficiently recognized by the enzymes at pH 7.1 to 9.0 and the polymerization reaction proceeded in a regio- and stereo-selective manner to give rise to artificial hyaluronic acid with molecular weight higher than 15000. These results strongly suggest that the transition state of these testicular hyaluronidases catalysis corresponds to a sugar oxazolinium ion. 相似文献
889.
890.