Solvent Effects on Protonation Constants of Imatinib in Different Aqueous Solutions of Methanol at T = 298.15 K

Russian Journal of Physical Chemistry A - Imatinib (Gleevec) is a drug that is applied to treat cancer. It inhibits the Bcr-Abl tyrosine-kinase and therefore, it can slow growth or result in...     

A Parham Cyclization route to the 2,3-dihydro-1H-indazole-1,2-dicarboxylate ring systems via condensation of thermolabile aryllithium reagents and azodicarboxylate esters

The Parham Cyclization reaction of o-lithiobenzyl chlorides (generated by low temperature halogen-metal exchange of the corresponding o-bromobenzyl chlorides with n-butyllithium) with azodicarboxylate esters provides a new entry to the 2,3-dihydro-1H-indazole-1,2-dicarboxylate ring system in moderate to good yield.     

Formation and structural study of a mixed ene/enyl ligand on reaction of [Ru(C5Me5)Cl2]2 with 1,3-cyclononadiene

The reaction of [Ru(C₅Me₅)Cl₂]₂ with an excess of 1,3-cyclononadiene in the presence of metallic zinc leads to Ru(C₅Me₅)(1,2,3,6,7-η⁵-C₉H₁₃), in which the nine-membered ring provides both allyl and olefin coordinations, linked together on each side by C₂H₄ bridges. The complex has been characterized analytically, spectroscopically, and structurally.     

Multiaxial and non-proportional loading responses,anisotropy and modeling of Ti–6Al–4V titanium alloy over wide ranges of strain rates and temperatures

Results from a series of multiaxial loading experiments on the Ti–6Al–4V titanium alloy are presented. Different loading conditions are applied in order to get the comprehensive response of the alloy. The strain rates are varied from the quasi-static to dynamic regimes and the corresponding material responses are obtained. The specimen is deformed to large strains in order to study the material behavior under finite deformation at various strain rates. Torsional Kolsky bar is used to achieve shear strain rates up to 1000 s⁻¹. Experiments are performed under non-proportional loading conditions as well as dynamic torsion followed by dynamic compression at various temperatures. The non-proportional loading experiments comprise of an initial uniaxial loading to a certain level of strain followed by biaxial loading, using a channel-type die at various rates of loadings. All the non-proportional experiments are carried out at room temperature. Experiments are also performed to investigate the anisotropic behavior of the alloy. An orthotropic yield criterion [proposed by Cazacu, O., Plunkett, B., Barlat, F., 2005. Orthotropic yield criterion for hexagonal closed packed metals. International Journal of Plasticity 22, 1171–1194.] for anisotropic hexagonal closed packed materials with strength differential is used to generate the yield surface. Based on the definition of the effective stress of this yield criterion, the observed material response for the different loading conditions under large deformation is modeled using the Khan–Huang–Liang (KHL) equation assuming isotropic hardening. The model constants used in the present study, were pre-determined from the extensive uniaxial experiments presented in the earlier paper [Khan, A.S., Suh, Y.S., Kazmi R., 2004. Quasi-static and dynamic loading responses and constitutive modeling of titanium alloys. International Journal of Plasticity 20, 2233–2248]. The model predictions are found to be extremely close to the observed material response.     

Synthesis,Characterization, and Applications of Copper Nanoparticles

Copper nanoparticles with different structural properties and effective biological effects may be fabricated using new green protocols. The control over particle size and in turn size-dependent properties of copper nanoparticles is expected to provide additional applications. Various methods for the synthesis of copper nanoparticles have been reported including chemical methods, physical methods, biological methods, and green synthesis. Biological methods involve the use of plant extracts, bacteria, and fungi. Commendable work has been done regarding the synthesis and stability of copper nanoparticles. There is a need to summarize the behavior of copper nanoparticles in different media under various conditions. Here, a complete list of the literature on the synthesis of copper nanoparticles, their properties, stabilizing agents, factors affecting the morphology, and their applications is presented. The importance of copper nanoparticles compared to other metal nanoparticles are due to high conductivity. Methods for the synthesis of copper nanoparticles, including green protocols using plants and micro-organisms compared chemical methods, have also been reviewed.