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71.
Nicholas J. Turro Jeffrey McVey V. Ramamurthy Peter Lechtken 《Angewandte Chemie (International ed. in English)》1979,18(8):572-586
An adiabatic photoreaction is a chemical process that occurs entirely on a single excited electronic energy surface. As a rule, most photoreactions of organic molecules start on an excited electronic surface but “jump” to a lower surface somewhere along the reaction coordinate. There are, however, exceptions to this general rule. For example, photoreactions involving small structural changes and minor alterations in covalent bonding (e.g., proton transfer and complex formation) are commonly found to occur adiabatically. The purpose of this review is to survey examples of more complicated adiabatic photoreactions such as fragmentation, electrocyclic rearrangements, and geometrical isomerizations. The concepts employed are presented in an introductory discussion. 相似文献
72.
The photochemistry of 31 alpha-oxoamides capable of undergoing gamma-hydrogen transfer has been examined within zeolites. These molecules, upon excitation, yield two products--a beta-lactam and oxazolidinone--in solution, both resulting from gamma-hydrogen transfer. While in benzene the major product is oxazolidinone, within an MY zeolite, the main product is a beta-lactam. In this investigation, we have focused our attention on asymmetric induction in the formation of the beta-lactam product. Two approaches--using a chiral inductor and chiral auxiliary--have been employed. While in solution, in the presence of chiral inductors, achiral alpha-oxoamides yield beta-lactams with zero enantioselectivity; within zeolites, an ee of up to 44% has been achieved. Alpha-oxoamides appended with a chiral auxiliary gave beta-lactams with less than 5% diastereoselectivity in solution while within zeolites, the same alpha-oxoamides gave the products with de's of up to 83%. Such a remarkable influence of zeolites is attributed to an alkali ion interaction with the reactant alpha-oxoamides and to the confined environment of the zeolite interior. At this stage, we have not been able to provide a model with predictive power and further work is needed to understand this valuable asymmetric induction strategy. 相似文献
73.
P.D. Shidling N. Madhavan V.S. Ramamurthy S. Nath N.M. Badiger Santanu Pal A.K. Sinha A. Jhingan S. Muralithar P. Sugathan S. Kailas B.R. Behera R. Singh K.M. Varier M.C. Radhakrishna 《Physics letters. [Part B]》2008
Evaporation residue (ER) cross sections and gamma multiplicity distributions have been measured for 16O + 184W and 19F + 181Ta systems in the excitation energy range of 50–90 MeV, leading to the same compound nucleus 200Pb∗. Comparison of experimental results of both the systems shows that ER cross sections and moments of gamma multiplicity distribution of 16O + 184W system are significantly higher than those of 19F + 181Ta system at higher excitation energies. Present measurements directly shows the experimental signature of entrance channel effect even with the systems which are not very different with respect to their entrance channel mass asymmetry. It is further demonstrated that the reduction in the ER cross section and moments of spin distribution for 19F + 181Ta system is mainly due to the suppression of fusion of higher l values. 相似文献
74.
Gunter Silber Dieter Flockerzi Rajendra Singh Varma Ramamurthy Charubala Eugen Uhlmann Wolfgang Pfleiderer 《Helvetica chimica acta》1981,64(5):1704-1716
Nucleotides. XV. Synthesis and Properties of 2′O-t-Butyldimethylsilyl-5′-O-monomethoxytritylribonucleoside-3′-phosphotriesters, Starting Materials for Oligonucleotide Syntheses The syntheses of two types of fully blocked ribonucleoside 3′-phosphotriesters 6–14 have been achieved in excellent yields from 2′-O-t-butyldimethylsilyl-5′-O-monomethoxytrityl-ribonucleosides 1–5 by phosphorylation with 2-chloro- and 2,5-dichlorophenylphosphorodichloridate respectively and subsequent treatment by cyanoethanol to 6 , 8 , 10 , 12 and 14 and by p-nitrophenylethanol to 7 , 9 , 11 and 13 . These phosphotriesters are valuable starting materials for oligonucleotide syntheses due to the fact that the corresponding phosphotriesters 15–23 with free HO? C(5′) could be obtained by detritylation and the 3′-phosphodiester triethylammonium salts 24–32 by deblocking of the cyanoethyl and the 2,5-dichlorophenyl group respectively. All newly synthesized compounds have been characterized by UV.-and NMR.-spectra as well as C, H, N elementary analyses. 相似文献
75.
76.
Krishna Radhakrishnan Satyajit Gupta Divya Prakash Gnanadhas Praveen C. Ramamurthy Dipshika Chakravortty Ashok M. Raichur 《Particle & Particle Systems Characterization》2014,31(4):449-458
The fabrication of a mesoporous silica nanoparticle (MSN)?protamine hybrid system (MSN?PRM) is reported that selectively releases drugs in the presence of specific enzyme triggers present in the proximity of cancer cells. The enzyme trigger involved is a protease called trypsin, which is overexpressed in certain specific pathological conditions, such as inflammation and cancer. Overexpression of trypsin is known to be associated with invasion, metastasis, and growth in several cancers, such as leukemia, colon cancer, and colorectal cancer. The current system (MSN–PRM) consists of an MSN support in which mesopores are capped with an FDA‐approved peptide drug protamine, which effectively blocks the outward diffusion of the drug molecules from the mesopores of the MSNs. On exposure to the enzyme trigger, the protamine cap disintegrates, opening up the molecular gates and releasing the entrapped drug molecules. The system exhibits minimal premature release in the absence of the trigger and selectively releases the encapsulated drugs in the presence of the proteases secreted by colorectal cancer cells. The ability of the MSN–PRM particles to deliver anticancer drugs to colorectal cancer cells has also been demonstrated. The hydrophobic drug is released into cancer cells subsequent to disintegration of the protamine cap, resulting in cell death. Drug‐induced cell death in colorectal cancer cells is significantly enhanced when the hydrophobic drug that is known to degrade in aqueous environments is encapsulated in the MSN–PRM system in comparison to the free drug (P < 0.05). The system, which shows good biocompatibility and selective drug release, is a promising platform for cancer specific drug delivery. 相似文献
77.
Spectral and photophysical properties of 1,6-naphthyridine derivatives: a new class of compounds for nonlinear optics 总被引:1,自引:0,他引:1
Indirapriyadharshini VK Ramamurthy P Raghukumar V Ramakrishnan VT 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2002,58(8):1535-1543
1,6-Naphthyridines are a class of compounds that exhibit second harmonic generation on excitation with a Nd-YAG laser (1064 nm). Solvatochromism has been used to estimate enhancement in the dipole moments on excitation and the values of first-order hyperpolarizability, beta. Photophysical studies on the title compounds show that they have a fluorescence lifetime of about 10 ns and fluorescence quantum yield of approximately 0.05-0.1 in different solvents. Kurtz powder method has been used to find the NLO efficiency of the compounds with reference to urea. 相似文献
78.
Prabhakaran R Kalaivani P Poornima P Dallemer F Paramaguru G Vijaya Padma V Renganathan R Huang R Natarajan K 《Dalton transactions (Cambridge, England : 2003)》2012,41(31):9323-9336
One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3 were obtained from the reaction between [NiCl(2)(PPh(3))(2)], 1,2-bis(diphenylphosphino)ethane, and [H(2)-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh(3))] (1) and [(Ni(Sal-tsc))(2)(μ-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2 and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions. 相似文献
79.
V Azzarito P Prabhakaran AI Bartlett NS Murphy MJ Hardie CA Kilner TA Edwards SL Warriner AJ Wilson 《Organic & biomolecular chemistry》2012,10(32):6469-6472
The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties. 相似文献
80.
The nucleon exchange process between two nuclei in close proximity and its application to an explanation of fragment mass
and charge distributions in fission and in heavy ion deep inelastic collisions are reviewed. An analysis of the measured correlations
between the energy loss from relative motion and the fragment mass and charge variances in the heavy ion deep inelastic collisions
is presented. The recent data on fragment mass and charge variances as a function of the fragment kinetic energy in thermal
neutron induced fission of235U, lends added support to the hypothesis that the nucleon transport process plays a similar role both in fission and in heavy
ion deep inelastic collisions. 相似文献