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51.
Vittorio Canale Magdalena Kotaska Anna Dziubina Matylda Stefaniak Agata Siwek Gabriela Starowicz Krzysztof Marciniec Patryk Kasza Grzegorz Sataa Beata Duszyska Xavier Bantreil Frdric Lamaty Marek Bednarski Jacek Sapa Pawe Zajdel 《Molecules (Basel, Switzerland)》2021,26(13)
The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α2-adrenoceptor might be beneficial for the treatment of depressive symptoms by increasing both norepinephrine and serotonin levels in certain brain areas. Moreover, the antidepressant properties of 5-HT7 receptor antagonists have been widely demonstrated in a large set of animal models. Considering the potential therapeutic advantages in targeting both α2-adrenoceptors and 5-HT7 receptors, we designed a small series of arylsulfonamide derivatives of (dihydrobenzofuranoxy)ethyl piperidines as dually active ligands. Following green chemistry principles, the designed compounds were synthesized entirely using a sustainable mechanochemical approach. The identified compound 8 behaved as a potent α2A/5-HT7 receptor antagonist and displayed moderate-to-high selectivity over α1-adrenoceptor subtypes and selected serotonin and dopaminergic receptors. Finally, compound 8 improved performance of mice in the forced swim test, displaying similar potency to the reference drug mirtazapine. 相似文献
52.
Kasprzyk-Kucewicz Teresa Cholewka Armand Bałamut Karolina Kownacki Patryk Kaszuba Natalia Kaszuba Michał Stanek Agata Sieroń Karolina Stransky Jiri Pasz Adam Morawiec Tadeusz 《Journal of Thermal Analysis and Calorimetry》2021,143(1):139-150
Journal of Thermal Analysis and Calorimetry - Coal has played a significant role in daily life. However, the highly effective combustion and reducing combustion-caused hazards of the coal still... 相似文献
53.
Karolina Marciszuk Dr. Tomasz Pieńkos Patryk Gontarz Dr. Andrzej Pelc 《Chemphyschem》2020,21(15):1695-1702
The generation of negative ions from SO2 in the gas phase was studied using the thermal surface ionization method. Six anion types were measured: O−, S−, SO−, and SO2− and anions with m/z=96 and m/z=128. The most abundant anion formed was S− and the formation routes are discussed for each of the six anions. O−, S−, and SO− are formed via dissociative electron attachment to the molecule, whereas the generation of SO2− and anions with m/z=96 and m/z=128 are probably associated with the formation of H2SO4 in the gas inlet system and the ion source. Using statistical thermodynamics the dissociation temperatures of SO2 and SO in the gas phase are calculated and values of above 1800 °C are obtained for both molecules. We also estimated the optimal filament temperatures for the formation of all anions measured, indicating that for SO2 the optimal temperature is related to the electron affinity of the molecules: the optimal temperature increases with decreasing value of the electron affinity for the molecule corresponding to the respective anion. 相似文献
54.
Nebeluk Robert Zarzycki Krzysztof Seredyński Dawid Chaber Patryk Figat Maksym Domański Paweł D. Zieliński Cezary 《Nonlinear dynamics》2023,111(9):8383-8395
Nonlinear Dynamics - Moving-object tracking using a pan–tilt camera setup is quite a well-known task in robotics. However, the presented research addresses specific properties of the tracked... 相似文献