Synthesis of benzyl substituted naphthalenes from benzylidene tetralones

A convenient and efficient synthesis of novel highly substituted dimethoxybenzylnaphthalenes, which are precursors to several dihydroxynaphthoic acids, is described. The approach involves the use of aldol chemistry to provide a number of benzylidene tetralones, which are converted to the target naphthalenes in three steps, with good to excellent yields. Grignard reaction of intermediate benzyl tetralones provided 1-substituted benzyl naphthalenes. The reported synthesis is flexible and scalable and provides access to naphthalenes having a variety of substitution patterns. These benzyl substituted naphthalenes are being converted to naphthoic acids and the bioactivities of these compounds are currently being investigated.     

Interprétation combinatoire des moments négatifs des valeurs de fonctions L au bord de la bande critique

We give a combinatorial interpretation of the negative moments of the values at the edge of the critical strip of the L functions of modular forms of GL(2) and GL(3). We deduce some results about the size of these numbers.     

The effect of oxygen rf discharge on pulsed laser deposition of oxide films

In this work final results on TiO₂ film deposition by Plasma Assisted Pulsed Laser Deposition (PAPLD) with an rf biased substrate are presented. In previous work it has been shown that PAPLD is an improvement over conventional PLD for the elimination of particulates in high refractive index thin film deposition. This paper will give a comparison between conventional PLD and PAPLD on the stoichiometry, morphology, and optical properties of deposited TiO₂ films. It will be demonstrated that oxygen rf discharge during the PLD process makes incorporation of oxygen into the depositing films extremely effective. This effect of the rf discharge allows operation of the PLD process at a lower oxygen background pressure while enhancing the deposition rate. Also, the production of a good quality TiO₂ film by PAPLD using a pure metal titanium target will be shown. PACS 79.20.Ds; 52.80.Pi     

The use of plane-polarized beams in controlled surface temperature laser heat treating

Plane-polarized CO₂ laser beams can be successfully employed in controlled surface temperature laser heat treating in order to improve the coupling between radiation and steel. The coupling efficiency has been quantitatively determined by means of a simple energy balance model, by using a medium-power CO₂ laser. In this way, the angle at which the best coupling can be obtained has also been singled out. Moreover, some heat treatments performed with a high power laser beam obliquely impinging on medium carbon steel samples have confirmed that controlled surface temperature laser heat treating can be completely free of the problems concerning the use of coatings generally employed.     

Synthèse d'éthers diéthylamino éthyliques de bibenzofurannes et de bis-benzofuryl cétones,comme analogues pharmacochimiques de la Tilorone

The diethylaminoethyl ethers of various bis[Bz-hydroxy]bibenzofurans have been synthesized, either from 2-hydroxy-5-methoxybenzyl alcohol, or from benzofurancarboxylic acids. The corresponding ethers of bis[Bz- hydroxy-2-benzofuryl]methanones were prepared from methoxysalicyl-aldehydes.     

Apertureless near field optical microscopy: a contribution to the understanding of the signal detected in the presence of a background field

Apertureless scanning near field optical microscopy techniques have become a common way of studying surface samples. By using a nano-probe that scatters the electromagnetic non-propagative waves emerging from a given sample, this microscopy provides optical images with a resolution beyond the diffraction limit. Despite a great diversity of works covering a wide variety of physical domains, the formation of the images obtained is not yet fully understood. The purpose of this letter is to assess the influence of the tip position and imposed oscillation of the tip in apertureless SNOM when a background field is added to the scattered near field. We propose a simple analytical model which enables us to account for the experimental results and explains how, depending on the experimental conditions, the near field signal can totally disappear or, on the contrary, be greatly enhanced.     

Entrance channels and alpha decay half-lives of the heaviest elements

The barriers standing against the formation of superheavy elements and their consecutive decay have been determined in the quasimolecular shape path within a Generalized Liquid Drop Model including the proximity effects between nucleons in a neck, the mass and charge asymmetry, a precise nuclear radius and the shell effects given by the Droplet Model. For moderately asymmetric reactions double-hump potential barriers stand and fast fission of compact shapes in the outer well is possible. Very asymmetric reactions lead to one hump barriers which can be passed only with a high energy relatively to the superheavy element energy. Then, only the emission of several neutrons or an particle can allow to reach an eventual ground state. For almost symmetric heavy-ion reactions, there is no more external well and the inner barrier is higher than the outer one. Predictions for partial decay half-lives are given.     

Lipschitz and darbo conditions for the superposition operator in some non-ideal spaces of smooth functions

Let X be a Banach space of differentiable functions and A: XX be a superposition operator. We consider for A the conditions

Synthesis and antiproliferative evaluation of glucosylated pyrazole analogs of K252c

Pyrazole analogs of the staurosporine aglycon K252c were recently described as potent inhibitors of the three Pim protein kinase isoforms. To evaluate the impact of the introduction of a sugar moiety on the biological activities of this heterocyclic scaffold, four new glucosylated pyrazole analogs of K252c were synthesized. Their biological evaluation demonstrated that most active compounds 11 and 19 substituted by a β-d-glucosyl moiety at N12 or N13 positions exhibited antiproliferative activities toward HCT116 cells.