喹啉及其衍生物的多相不对称氢转移反应

喹啉及其衍生物的多相不对称氢转移是制备杂环手性化合物的理想策略.多相手性催化体系具有催化剂可循环利用及产物分离提纯容易等优势.然而,喹啉及其衍生物的多相手性高效催化体系鲜有报道.这主要是由于多相手性氢转移为水-油-固三相反应,在反应的过程中,传质问题极大影响固体催化剂的催化性能.因此,发展具有相转移功能的手性催化材料,...     

Synthesis of CeO2-NPs by chemical and biological methods and their photocatalytic,antibacterial and in vitro antioxidant activity

Research on Chemical Intermediates - In the present study, biosynthesized CeO2-NPs using Solanum nigrum leaf extract were compared with chemically synthesized one. The synthesized CeO2-NPs were...     

Density functional study on the structural conformations and intramolecular charge transfer from the vibrational spectra of the anticancer drug combretastatin‐A2

Combretastatin‐A2 (CA2), a potential anticancer drug in advanced preclinical development, is extracted from the medicinal plant C ombretum caffrum. The NIR‐FT Raman and FT‐IR spectral studies of the molecule were carried out and a b initio calculations performed at the B3LYP/6‐31G(d) level to derive the equilibrium geometry as well as the vibrational wavenumbers and intensities of the spectral bands. The vibrational analysis showed that the molecule has a similar geometry as that of c is‐stilbene, and has undergone steric repulsion resulting in twisting of the phenyl ring with respect to the ethylenic plane. Vibrational analysis was used to investigate the lowering of the stretching modes, and enhancement of infrared band intensities of the C–H stretching modes of Me2 may be attributed to the electronic effects caused by back‐donation and induction from the oxygen atom. Analysis of phenyl ring modes shows that the CA2 stretching mode 8 and the aromatic C–H in‐plane bending mode are equally active as strong bands in both IR and Raman spectra, which can be interpreted as the evidence of intramolecular charge transfer (ICT) between the OH and OCH₃groups via conjugated ring path and is responsible for bioactivity of the molecule. Copyright © 2008 John Wiley & Sons, Ltd.     

Azure A chloride: computational and spectroscopic study

Fourier transform Raman and IR as well as UV–visible spectra of the phenothiazine dye Azure A chloride, 3‐amino‐7‐(dimethylamino) phenothiazin‐5‐ium chloride were recorded and analyzed. The spectral interpretation was done following full structure optimization and vibrational wavenumber calculations based on the density functional theory (DFT) using the standard B3LYP/6‐31G(d) basis set. The N H stretching wavenumber is found to be lowered owing to intermolecular N H···S hydrogen bonding. The downshift of C H stretching wavenumber is discussed. The first hyperpolarizability of the dye is calculated. Time‐dependent density functional theory (TD‐DFT) calculations of electronic spectra were performed on the optimized structure and compared with the experimental UV–visible spectrum. The atomic net charges of the molecule reveal the  M effect of the nitrogen atoms in the molecule. Stability of the molecule arising from hyperconjugative interactions leading to its nonlinearity and bioactivity, charge delocalization and mesomeric effects have been analyzed using natural bond orbital (NBO) analysis. Copyright © 2008 John Wiley & Sons, Ltd.     

Positron annihilation studies in ZnO nanoparticles

We report results on positron annihilation spectroscopic (PAS) studies using lifetime and coincidence Doppler broadening techniques in zinc oxide (ZnO) nanoparticles (4 to 40 nm) synthesized by solid state pyrolytic reaction followed by annealing in the temperature range of 200 ^°C to 800 ^°C. Positron lifetime in the nanoparticles are observed to be higher than bulk lifetime in all the cases. Theoretical calculation of lifetime indicates the presence of either Zn or (Zn, O) vacancy clusters which migrate and anneal out at high temperature. Comparison of ratio spectra from coincidence Doppler broadening measurement and calculated electron momentum distribution indicates the presence of either Zn or (Zn, O) vacancies. In addition, photoluminescence (PL) measurements have been carried out to examine the role of defects on the intensity of emission in the visible region.     

Newly Isolated Lactic Acid Bacteria with Probiotic Features for Potential Application in Food Industry

Five newly isolated lactic acid bacteria were identified as Weissella cibaria, Enterococcus faecium, and three different strains of Lactobacillus plantarum by 16S rRNA sequencing. Essential probiotic requirements of these isolates such as tolerance to phenol, low pH, high sodium chloride, and bile salt concentration were checked. Efficiency in adherence to mucin and hydrophobicity of the bacterial cell were also evaluated by in vitro studies. Antimicrobial activities against some pathogens were tried, and the sensitivity of these strains against 25 different antibiotics was also checked. Further studies revealed Weissella and Enterococcus as substantial producers of folic acid. Folate is involved as a cofactor in many metabolic reactions, and it has to be an essential component in the human diet. The folate level in the fermented samples was determined by microbiological assay using Lactobacillus casei NCIM 2364 as indicator strain. The three strains of L. plantarum showed significant inhibitory activity against various fungi that commonly contaminate food stuffs indicating their potential as a biopreservative of food material.     

Quantification of defects in composites and rubber materials using active thermography

Active (lock-in and pulsed) thermography technique is used to quantify defect features in specimens of glass fiber reinforced polymer, high density rubber, low density rubber and aluminum bonded low density rubber with artificially produced defects. The relationship between phase contrast and thermal contrast with defect features are examined. Using lock-in approach, the optimal frequencies for different specimens are determined experimentally. It is observed that with increasing defect depth, the phase contrast increases while the thermal contrast decreases. Defects with radius to depth ratio greater than 1.0 are found to be discernible. The phase difference between sound and defective region as a function of square root of excitation frequency for glass fiber reinforced polymer specimen is found to be in good agreement with the predictions of Bennet and Patty model [1]. Further, using pulsed thermography, the defects depth could be measured accurately for glass fiber reinforced polymer specimen from the thermal contrast using the analytical approach of Balageas et al. [2].     

Feasibility studies on the electrochemical recovery of fission platinoids from high-level liquid waste

The electrochemical behavior of ruthenium(III) and rhodium(III) in nitric acid medium has been studied at platinum and stainless steel electrodes by cyclic voltammetry. The cyclic voltammograms consisted of surge in cathodic current occurring at potentials of −0.13 V (Vs. Pd) and −0.15 V (Vs. Pd), which culminates into peaks at −0.47 V and −0.5 V due to the reductions of Ru(III) and Rh(III) to their metallic forms, respectively. Electrodeposition was carried out at stainless steel electrode and unlike palladium, the recovery of ruthenium and rhodium was limited to ~4% and ~14%, respectively. However, a different scenario was observed in case of electrodeposition from a ternary solution containing all these platinum metals. Ruthenium and rhodium deposited underpotentially in the presence of palladium and the recovery of ~20% and ~5% was observed for ruthenium and rhodium, respectively. Evolution of RuO₄ at the anode and deposition of RuO₂ in the anodic side was observed in all cases during electrolysis of ruthenium(III) containing solutions.     

Nonstructural geometric discontinuities in finite element/multibody system analysis

Existing multibody system (MBS) algorithms treat articulated system components that are not rigidly connected as separate bodies connected by joints that are governed by nonlinear algebraic equations. As a consequence, these MBS algorithms lead to a highly nonlinear system of coupled differential and algebraic equations. Existing finite element (FE) algorithms, on the other hand, do not lead to a constant mesh inertia matrix in the case of arbitrarily large relative rigid body rotations. In this paper, new FE/MBS meshes that employ linear connectivity conditions and allow for arbitrarily large rigid body displacements between the finite elements are introduced. The large displacement FE absolute nodal coordinate formulation (ANCF) is used to obtain linear element connectivity conditions in the case of large relative rotations between the finite elements of a mesh. It is shown in this paper that a linear formulation of pin (revolute) joints that allow for finite relative rotations between two elements connected by the joint can be systematically obtained using ANCF finite elements. The algebraic joint constraint equations, which can be introduced at a preprocessing stage to efficiently eliminate redundant position coordinates, allow for deformation modes at the pin joint definition point, and therefore, this new joint formulation can be considered as a generalization of the pin joint formulation used in rigid MBS analysis. The new pin joint deformation modes that are the result of C ⁰ continuity conditions, allow for the calculations of the pin joint strains which can be discontinuous as the result of the finite relative rotation between the elements. This type of discontinuity is referred to in this paper as nonstructural discontinuity in order to distinguish it from the case of structural discontinuity in which the elements are rigidly connected. Because ANCF finite elements lead to a constant mass matrix, an identity generalized mass matrix can be obtained for the FE mesh despite the fact that the finite elements of the mesh are not rigidly connected. The relationship between the nonrational ANCF finite elements and the B-spline representation is used to shed light on the potential of using ANCF as the basis for the integration of computer aided design and analysis (I-CAD-A). When cubic interpolation is used in the FE/ANCF representation, C ⁰ continuity is equivalent to a knot multiplicity of three when computational geometry methods such as B-splines are used. C ² ANCF models which ensure the continuity of the curvature and correspond to B-spline knot multiplicity of one can also be obtained. Nonetheless, B-spline and NURBS representations cannot be used to effectively model T-junctions that can be systematically modeled using ANCF finite elements which employ gradient coordinates that can be conveniently used to define element orientations in the reference configuration. Numerical results are presented in order to demonstrate the use of the new formulation in developing new chain models.     

First Synthesis of Bis(di(indolyl)aryl)methanes From Bis(salicylaldehydes)

In this article, a simple method for the synthesis of bis(di(indolyl)aryl)methanes is described. The iodine‐catalyzed (5 mol %) reaction of indoles with various bis(salicylaldehyde) derivatives affords the bis(di(indolyl)aryl)methanes in excellent yields. The reaction works well under mild reaction condition with shorter reaction time.