Convergence analysis of a global optimization algorithm using stochastic differential equations

We establish the convergence of a stochastic global optimization algorithm for general non-convex, smooth functions. The algorithm follows the trajectory of an appropriately defined stochastic differential equation (SDE). In order to achieve feasibility of the trajectory we introduce information from the Lagrange multipliers into the SDE. The analysis is performed in two steps. We first give a characterization of a probability measure (Π) that is defined on the set of global minima of the problem. We then study the transition density associated with the augmented diffusion process and show that its weak limit is given by Π.     

Bilinear modeling solution approach for fixed charge network flow problems

We present a continuous, bilinear formulation for the fixed charge network flow problem. This formulation is used to derive an exact algorithm for the fixed charge network flow problem converging in a finite number of steps. Some preliminary computational experiments are reported to show the performance of the algorithm.     

Adaptive dynamic cost updating procedure for solving fixed charge network flow problems

We approximate the objective function of the fixed charge network flow problem (FCNF) by a piecewise linear one, and construct a concave piecewise linear network flow problem (CPLNF). A proper choice of parameters in the CPLNF problem guarantees the equivalence between those two problems. We propose a heuristic algorithm for solving the FCNF problem, which requires solving a sequence of CPLNF problems. The algorithm employs the dynamic cost updating procedure (DCUP) to find a solution to the CPLNF problems. Preliminary numerical experiments show the effectiveness of the proposed algorithm. In particular, it provides a better solution than the dynamic slope scaling procedure in less CPU time. Research was partially supported by NSF and Air Force grants.     

Online nanoelectrospray/high‐field asymmetric waveform ion mobility spectrometry as a potential tool for discovery pharmaceutical bioanalysis

Nanoelectrospray ionization (nESI) coupled online with high‐field asymmetric waveform ion mobility spectrometry (FAIMS) for small molecule analysis in a discovery pharmaceutical setting was examined. A conventional capillary pump, autosampler and nESI source were used to introduce samples directly into the FAIMS device. The FAIMS device was used to separate gas‐phase ions on a timescale that was compatible with the mass spectrometer. The capability of the nESI‐FAIMS combination to efficiently remove metabolite interferences from the parent drug, and reduce ion suppression effects, was demonstrated. On average, 85% of the signal intensity obtained from a neat sample was preserved in the extracted plasma samples. Standard curves were prepared for several compounds. Linearity was obtained over approximately 3 to 4 orders of magnitude. Comparison of results from nESI‐FAIMS with those from conventional LC/MS for a mouse pharmacokinetic study yielded concentration values differing by no more than 30%. Copyright © 2009 John Wiley & Sons, Ltd.     

Jamming communication networks under complete uncertainty

This paper describes a problem of interdicting/jamming wireless communication networks in uncertain environments. Jamming communication networks is an important problem with many applications, but has received relatively little attention in the literature. Most of the work on network interdiction is focused on preventing jamming and analyzing network vulnerabilities. Here, we consider the case where there is no information about the network to be jammed. Thus, the problem is reduced to jamming all points in the area of interest. The optimal solution will determine the locations of the minimum number of jamming devices required to suppress the network. We consider a subproblem which places jamming devices on the nodes of a uniform grid over the area of interest. The objective here is to determine the maximum grid step size. We derive upper and lower bounds for this problem and provide a convergence result. Further, we prove that due to the cumulative effect of the jamming devices, the proposed method produces better solutions than the classical technique of covering the region with uniform circles.     

Convergence Criteria for Hierarchical Overlapping Coordination of Linearly Constrained Convex Design Problems

Decomposition of multidisciplinary engineering system design problems into smaller subproblems is desirable because it enhances robustness and understanding of the numerical results. Moreover, subproblems can be solved in parallel using the optimization technique most suitable for the underlying mathematical form of the subproblem. Hierarchical overlapping coordination (HOC) is an interesting strategy for solving decomposed problems. It simultaneously uses two or more design problem decompositions, each of them associated with different partitions of the design variables and constraints. Coordination is achieved by the exchange of information between decompositions. This article presents the HOC algorithm and several new sufficient conditions for convergence of the algorithm to the optimum in the case of convex problems with linear constraints. One of these equivalent conditions involves the rank of the constraint matrix that is computationally efficient to verify. Computational results obtained by applying the HOC algorithm to quadratic programming problems of various sizes are included for illustration.     

Stability and topology of scale-free networks under attack and defense strategies

We study tolerance and topology of random scale-free networks under attack and defense strategies that depend on the degree k of the nodes. This situation occurs, for example, when the robustness of a node depends on its degree or in an intentional attack with insufficient knowledge of the network. We determine, for all strategies, the critical fraction p(c) of nodes that must be removed for disintegrating the network. We find that, for an intentional attack, little knowledge of the well-connected sites is sufficient to strongly reduce p(c). At criticality, the topology of the network depends on the removal strategy, implying that different strategies may lead to different kinds of percolation transitions.