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221.
    
Nanoelectrospray ionization (nESI) coupled online with high‐field asymmetric waveform ion mobility spectrometry (FAIMS) for small molecule analysis in a discovery pharmaceutical setting was examined. A conventional capillary pump, autosampler and nESI source were used to introduce samples directly into the FAIMS device. The FAIMS device was used to separate gas‐phase ions on a timescale that was compatible with the mass spectrometer. The capability of the nESI‐FAIMS combination to efficiently remove metabolite interferences from the parent drug, and reduce ion suppression effects, was demonstrated. On average, 85% of the signal intensity obtained from a neat sample was preserved in the extracted plasma samples. Standard curves were prepared for several compounds. Linearity was obtained over approximately 3 to 4 orders of magnitude. Comparison of results from nESI‐FAIMS with those from conventional LC/MS for a mouse pharmacokinetic study yielded concentration values differing by no more than 30%. Copyright © 2009 John Wiley & Sons, Ltd.  相似文献   
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Human Learning Optimization is a simple but efficient meta-heuristic algorithm in which three learning operators, i.e. the random learning operator, the individual learning operator, and the social learning operator, are developed to efficiently search the optimal solution by imitating the learning mechanisms of human beings. However, HLO assumes that all the individuals possess the same learning ability, which is not true in a real human population as the IQ scores of humans, one of the most important indices of the learning ability of humans, follow Gaussian distribution and increase with the development of society and technology. Inspired by this fact, this paper proposes a Diverse Human Learning Optimization algorithm (DHLO), into which the Gaussian distribution and dynamic adjusting strategy are introduced. By adopting a set of Gaussian distributed parameter values instead of a constant to diversify the learning abilities of DHLO, the robustness of the algorithm is strengthened. In addition, by cooperating with the dynamic updating operation, DHLO can adjust to better parameter values and consequently enhances the global search ability of the algorithm. Finally, DHLO is applied to tackle the CEC05 benchmark functions as well as knapsack problems, and its performance is compared with the standard HLO as well as the other eight meta-heuristics, i.e. the Binary Differential Evolution, Simplified Binary Artificial Fish Swarm Algorithm, Adaptive Binary Harmony Search, Binary Gravitational Search Algorithms, Binary Bat Algorithms, Binary Artificial Bee Colony, Bi-Velocity Discrete Particle Swarm Optimization, and Modified Binary Particle Swarm Optimization. The experimental results show that the presented DHLO outperforms the other algorithms in terms of search accuracy and scalability.  相似文献   
224.
DIRECT is derivative-free global-search algorithm has been found to perform robustly across a wide variety of low-dimensional test problems. The reason DIRECT’s robustness is its lack of algorithmic parameters that need be “tuned” to make the algorithm perform well. In particular, there is no parameter that determines the relative emphasis on global versus local search. Unfortunately, the same algorithmic features that enable DIRECT to perform so robustly have a negative side effect. In particular, DIRECT is usually quick to get close to the global minimum, but very slow to refine the solution to high accuracy. This is what we call DIRECT’s “eventually inefficient behavior.” In this paper, we outline two root causes for this undesirable behavior and propose modifications to eliminate it. The paper builds upon our previously published “MrDIRECT” algorithm, which we can now show only addressed the first root cause of the “eventually inefficient behavior.” The key contribution of the current paper is a further enhancement that allows MrDIRECT to address the second root cause as well. To demonstrate the effectiveness of the enhanced MrDIRECT, we have identified a set of test functions that highlight different situations in which DIRECT has convergence issues. Extensive numerical work with this test suite demonstrates that the enhanced version of MrDIRECT does indeed improve the convergence rate of DIRECT.  相似文献   
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We approximate the objective function of the fixed charge network flow problem (FCNF) by a piecewise linear one, and construct a concave piecewise linear network flow problem (CPLNF). A proper choice of parameters in the CPLNF problem guarantees the equivalence between those two problems. We propose a heuristic algorithm for solving the FCNF problem, which requires solving a sequence of CPLNF problems. The algorithm employs the dynamic cost updating procedure (DCUP) to find a solution to the CPLNF problems. Preliminary numerical experiments show the effectiveness of the proposed algorithm. In particular, it provides a better solution than the dynamic slope scaling procedure in less CPU time. Research was partially supported by NSF and Air Force grants.  相似文献   
227.
Decomposition of multidisciplinary engineering system design problems into smaller subproblems is desirable because it enhances robustness and understanding of the numerical results. Moreover, subproblems can be solved in parallel using the optimization technique most suitable for the underlying mathematical form of the subproblem. Hierarchical overlapping coordination (HOC) is an interesting strategy for solving decomposed problems. It simultaneously uses two or more design problem decompositions, each of them associated with different partitions of the design variables and constraints. Coordination is achieved by the exchange of information between decompositions. This article presents the HOC algorithm and several new sufficient conditions for convergence of the algorithm to the optimum in the case of convex problems with linear constraints. One of these equivalent conditions involves the rank of the constraint matrix that is computationally efficient to verify. Computational results obtained by applying the HOC algorithm to quadratic programming problems of various sizes are included for illustration.  相似文献   
228.
In this paper we present the application of a method of adaptive estimation using an algebra–geometric approach, to the study of dynamic processes in the brain. It is assumed that the brain dynamic processes can be described by nonlinear or bilinear lattice models. Our research focuses on the development of an estimation algorithm for a signal process in the lattice models with background additive white noise, and with different assumptions regarding the characteristics of the signal process. We analyze the estimation algorithm and implement it as a stochastic differential equation under the assumption that the Lie algebra, associated with the signal process, can be reduced to a finite dimensional nilpotent algebra. A generalization is given for the case of lattice models, which belong to a class of causal lattices with certain restrictions on input and output signals. The application of adaptive filters for state estimation of the CA3 region of the hippocampus (a common location of the epileptic focus) is discussed. Our areas of application involve two problems: (1) an adaptive estimation of state variables of the hippocampal network, and (2) space identification of the coupled ordinary equation lattice model for the CA3 region.  相似文献   
229.
Jamming communication networks under complete uncertainty   总被引:1,自引:0,他引:1  
This paper describes a problem of interdicting/jamming wireless communication networks in uncertain environments. Jamming communication networks is an important problem with many applications, but has received relatively little attention in the literature. Most of the work on network interdiction is focused on preventing jamming and analyzing network vulnerabilities. Here, we consider the case where there is no information about the network to be jammed. Thus, the problem is reduced to jamming all points in the area of interest. The optimal solution will determine the locations of the minimum number of jamming devices required to suppress the network. We consider a subproblem which places jamming devices on the nodes of a uniform grid over the area of interest. The objective here is to determine the maximum grid step size. We derive upper and lower bounds for this problem and provide a convergence result. Further, we prove that due to the cumulative effect of the jamming devices, the proposed method produces better solutions than the classical technique of covering the region with uniform circles.  相似文献   
230.
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