From Endomorphisms to Automorphisms and Back: Dilations and Full Corners

When S is a discrete subsemigroup of a discrete group G suchthat G = S^–1S, it is possible to extend circle-valuedmultipliers from S to G, to dilate (projective) isometric representationsof S to (projective) unitary representations of G, and to dilate/extendactions of S by injective endomorphisms of a C*-algebra to actionsof G by automorphisms of a larger C*-algebra. These dilationsare unique provided they satisfy a minimality condition. The(twisted) semigroup crossed product corresponding to an actionof S is isomorphic to a full corner in the (twisted) crossedproduct by the dilated action of G. This shows that crossedproducts by semigroup actions are Morita equivalent to crossedproducts by group actions, making powerful tools available tostudy their ideal structure and representation theory. The dilationof the system giving the Bost–Connes Hecke C*-algebrafrom number theory is constructed explicitly as an application:it is the crossed product C₀(A_f)Q*₊, corresponding to the multiplicativeaction of the positive rationals on the additive group A_f offinite adeles.     

The heavy-ion magnetic spectrometer PRISMA

PRISMA is a magnetic spectrometer installed at Laboratori Nazionali di Legnaro (Italy) and designed for A=100–200, E=5–10 MeV-per-nucleon beams, and for possible use with the proposed radioactive beam facility SPES. The foremost features of the instrument are presented, along with the outline of two data analyses exemplifying the effectiveness of PRISMA-CLARA in studies of reaction dynamics.     

Hydrogen bonding in 2‐(2‐oxothiazolidin‐3‐yl)‐4,5‐dihydrothiazolium hydrogen sulfate monohydrate

The asymmetric unit of the title compound, C₆H₉N₂OS₂⁺·HSO₄⁻·H₂O, contains a heterocyclic cation, a hydrogen sulfate anion and a water molecule. There are strong hydrogen bonds between the hydrogen sulfate anions and water molecules, forming an infinite chain along the [010] direction, from which the cations are pendent. The steric, electronic and geometric features are compared with those of similar compounds. In this way, structural relationships are stated in terms of the influence of the sulfate group on the protonation of the heterocycle and on the tautomeric equilibrium in the solid state.     

Electrochemical Assay to Quantify the Hydroxyl Radical Scavenging Activity of Medicinal Plant Extracts

A new electrochemical assay has been developed which is based on quantifying the attack of OH^. radicals on a self‐assembled thiol monolayer on electrodes in the presence and absence of antioxidants. The OH^. radicals were produced in Fenton solutions. The radical scavengers diminish the concentration of the OH^. radicals in the Fenton solution, and the extent of thiol layer destruction is monitored with the help of a redox probe in solution, the signal of which is only generated at SAM‐free electrode surface. The results of the electrochemical assay were compared with those of the standard DPPH^. assay. In case of each plant extract, an excellent linear correlation was observed between the radical scavenging activity and the concentration of plant extracts; however, the scavenging properties of different plants strongly differ in the electrochemical and the DPPH^. assay. Since the proposed new method probes the reactivity of radical scavengers towards OH^., one of the most important reactive oxygen radicals in tissues, it is supposed to provide much more relevant information than the DPPH^. or other assays.     

Dynamics of multiple degree Ginzburg–Landau vortices

For the two-dimensional complex parabolic Ginzburg–Landau equation we prove that, asymptotically, vortices evolve according to a simple ordinary differential equation, which is a gradient flow of the Kirchhoff–Onsager functional. This convergence holds except for a finite number of times, corresponding to vortex collisions and splittings, which we describe carefully. The only assumption is a natural energy bound on the initial data. To cite this article: F. Bethuel et al., C. R. Acad. Sci. Paris, Ser. I 342 (2006).     

Direct Numerical Simulation of an Accelerating Channel Flow

Direct Numerical Simulation of a linearly accelerating channel flow starting from an initially statistically steady turbulent flow has been performed. It is shown that the response of the accelerating flow is fundamentally the same as that of the step-change transient flow described in He and Seddighi (J Fluid Mech 715:60–102, 2013). The flow structure again behaves like a boundary layer bypass transition undergoing three distinct phases, namely, (i) initially (pre-transition), the flow is laminar-like and the pre-existing turbulent structures are modulated resulting in elongated streaks leading to a strong and continuous increase in the streamwise fluctuating velocity but little changes in the other two components; (ii) it then undergoes transition when isolated turbulent spots are generated which spread and merge with each other, and (iii) they eventually cover the entire surface of the wall when the flow is fully turbulent. The similarity between the turbulence responses in the two flows is significant noting the contrasting features of the two types of mean flow unsteadiness: in the step-change flow, a sharp boundary layer is resulted in nearly instantly on the wall which closely resembles the spatially developing boundary layer, whereas the linear flow acceleration causes a continuing change of velocity gradient adjacent to the wall which propagates into the flow field with time, resulting in a gradually-developing boundary layer. There are, however, quantitative differences in the detailed behavior of the two flows and especially the transition is much delayed in the accelerating flow. It is also shown that the late pre-transition and early transition stages in both flows are characterised by significantly increased inwards sweep events in the wall region and ejection events in the outer layer. The flatness of the wall-normal velocity increases markedly near the wall around the time of onset of transition as a consequence of the huge intermittency of the velocity fluctuations. That is, there are long periods of quiescent flow coupled with occasional turbulent bursts.     

Multiple-steering QM-MM calculation of the free energy profile in chorismate mutase

A novel technique for computing free energy profiles in enzymatic reactions using the multiple steering molecular dynamics approach in the context of an efficient QM-MM density functional scheme is presented. The conversion reaction of chorismate to prephenate catalyzed by the Bacillus subtilis enzyme chorismate mutase has been chosen as an illustrative example.     

Ultrastructural architecture of colonies of different morphologies produced by phenotypic switching of a clinical strain of Candida tropicalis and biofilm formation by variant phenotypes

Candida tropicalis has been identified as one of the most prevalent pathogenic yeast species of the Candida-non-albicans (CNA) group. Study of switching in C. tropicalis has not been the subject of extensive research. Therefore, we investigated switching event and characterized the ultrastructural architecture of different phenotypes and biofilm produced in a C. tropicalis clinical strain. Cells switched heritably, reversibly, and at a high frequency between four phenotypes readily distinguishable by the shape of colonies formed on agar at 25°C. SEM analysis was used to verify the architecture of whole Candida colonies at ultrastructural level. The smooth phenotype (parental phenotype) colony showed a hemispherical shape character, while the semi-smooth was characterized by the presence of shallow marginal depressions. The ring and rough phenotypes exhibited more complex architecture and were characterized by the presence of deep central and peripheral depressions areas. The biofilm-forming ability varied among the switch phenotypes. After 12h incubation, the smooth phenotype formed less biofilm compared to the other phenotypes (P<0.05). The electron microscopy analysis revealed that filamentation (pseudohyphae) was associated with ring and rough colonies. The ultrastructural analysis allowed the observation of the arrangement of individual cells within the colonies. At the deep central and peripheral depressions areas of the ring and rough colonies extracellular material was seen in different arrangements. The data presented here open new avenues to study a possible role for extracellular material in the formation and maintenance of the architecture of switch phenotypes in C. tropicalis. It is therefore essential that more strains be investigated to determine the biological significance of extracellular material in C. tropicalis phenotypic switching phenomenon.     

Cu(II)-catalyzed enantioselective aldol condensation between malonic acid hemithioesters and aldehydes

A mild, decarboxylative, aldol-type addition of malonic acid hemithioesters to aldehydes has been shown to occur with up to 39% enantioselectivity when the reaction was carried out in the presence of catalytic amounts of a Cu(II) salt, an enantiopure, tartaric acid-derived bis-benzimidazole and an achiral base.