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981.
982.
Benz M Rosenberg KJ Kramer EJ Israelachvili JN 《The journal of physical chemistry. B》2006,110(24):11884-11893
Using a surface forces apparatus (SFA) and an atomic force microscope (AFM) we have studied the effects of surface roughness (root-mean-square (RMS) roughness between 0.3 and 220 nm) on the "contact mechanics", which describes the deformations and loading and unloading adhesion forces, of various polymeric surfaces. For randomly rough, moderately stiff, elastomeric surfaces, the force-distance curves on approach and separation are nearly reversible and almost perfectly exponentially repulsive, with an adhesion on separation that decreases only slightly with increasing RMS. Additionally, the magnitude of the preload force is seen to play a large role in determining the measured adhesion. The exponential repulsion likely arises from the local compressions (fine-grained nano- or submicron-scale deformations) of the surface asperities. The resulting characteristic decay lengths of the repulsion scale with the RMS roughness and correlate very well with a simple finite element method (FEM) analysis based on actual AFM topographical images of the surfaces. For "patterned" surfaces, with a nonrandom terraced structure, no similar exponential repulsion is observed, suggesting that asperity height variability or random roughness is required for the exponential behavior. However, the adhesion force or energy between two "patterned" surfaces fell off dramatically and roughly exponentially as the RMS increased, likely owing to a significant decrease in the contact area which in turn determines their adhesion. For both types of rough surfaces, random and patterned, the coarse-grained (global, meso- or macroscopic) deformations of the initially curved surfaces appear to be Hertzian. 相似文献
983.
Barbosa LR Caetano W Itri R Homem-de-Mello P Santiago PS Tabak M 《The journal of physical chemistry. B》2006,110(26):13086-13093
In this work, small-angle X-ray scattering (SAXS) studies on the interaction of the phenothiazine cationic compounds trifluoperazine (TFP, 2-10 mM) and chlorpromazine (CPZ, 2-10 mM) with micelles of the zwitterionic surfactant L-alpha-lysophosphatidylcholine (LPC, 30 mM), at pHs 4.0 and 7.0, are reported. The SAXS results demonstrate that, upon addition of both phenothiazines, the LPC micelle of prolate ellipsoidal shape changes into a cylindrically shaped micelle, increasing its axial ratio from 1.6 +/- 0.1 (in the absence of drug) to 2.5 +/- 0.1 (for 5 and 10 mM of phenothiazine). Such an effect is accompanied by a shrinking of the paraffinic shortest semiaxis from 22.5 +/- 0.3 to 20.0 +/- 0.5 A. Besides, a significant increase in polar shell electron density from 0.39(1) to 0.45(1) e/A3 is observed, consistent with cylinder-like aggregate geometry. Moreover, an increase of the phenothiazine concentration induces the appearance of a repulsive interference function over the SAXS curve of zwitterionic micelles, which is typical of interaction between surface-charged micelles. Such a finding provides evidence that the positively charged phenothiazine molecule must be accommodated near the hydrophobic/hydrophilic inner micellar interface in such a way that a net surface charge is altered with respect to the original overall neutral zwitterionic micelle. Such phenothiazine location is favored by both electrostatic and hydrophobic contributions, giving rise to binding constant values, obtained from electronic absorption results, that are quite larger compared to their binding to another zwitterionic surfactant, 3-(N-hexadecyl-N,N-dimethylammonio)propanesulfonate (HPS) (Caetano, W., et al. J. Colloid Int. Sci. 2003, 260, 414-422). Comparisons are made by means of theoretical calculations of the surfactant headgroup dipole moments for monomers of LPC and HPS. The theoretical results show that the dipole moment in LPC is almost perpendicular to the methylene chain, while a significant contribution along the methylene chain occurs for HPS. Besides, evidence is presented for extensive delocalization of the charges in the headgroups, which could be also relevant for the binding of the drugs. 相似文献
984.
We have carried out an extensive exploration of the gas-phase basicity of archetypal neutral bases across the periodic system using the generalized gradient approximation (GGA) of the density functional theory (DFT) at BP86/QZ4P//BP86/TZ2P. First, we validate DFT as a reliable tool for computing proton affinities and related thermochemical quantities: BP86/QZ4P//BP86/TZ2P is shown to yield a mean absolute deviation of 2.0 kcal/mol for the proton affinity at 298 K with respect to experiment, and 1.2 kcal/mol with high-level ab initio benchmark data. The main purpose of this work is to provide the proton affinities (and corresponding entropies) at 298 K of the neutral bases constituted by all maingroup-element hydrides of groups 15-17 and the noble gases, that is, group 18, and periods 1-6. We have also studied the effect of step-wise methylation of the protophilic center of the second- and third-period bases. 相似文献
985.
van Bochove MA Swart M Bickelhaupt FM 《Journal of the American Chemical Society》2006,128(33):10738-10744
Pentacoordinate phosphorus species play a key role in organic and biological processes. Yet, their nature is still not fully understood, in particular, whether they are stable, intermediate transition complexes (TC) or labile transition states (TS). Through systematic, theoretical analyses of elementary S(N)2@C, S(N)2@Si, and S(N)2@P reactions, we show how increasing the coordination number of the central atom as well as the substituents' steric demand shifts the S(N)2@P mechanism stepwise from a single-well potential (with a stable central TC) that is common for substitution at third-period atoms, via a triple-well potential (featuring a pre- and post-TS before and after the central TC), back to the double-well potential (in which pre- and postbarrier merge into one central TS) that is well-known for substitution reactions at carbon. Our results highlight the steric nature of the S(N)2 barrier, but they also show how electronic effects modulate the barrier height. 相似文献
986.
Pisula W Kastler M Wasserfallen D Davies RJ García-Gutiérrez MC Müllen K 《Journal of the American Chemical Society》2006,128(45):14424-14425
A hexa-peri-hexabenzocoronene carrying six long, branched alkyl chains has been processed in nano- and macroscopic pore templates. An extraordinary self-organization of this material was observed within macroscopically large glass capillaries after cooling from the isotropic phase. Thereby, the columnar structures were long-range aligned along the capillary axis over several centimeters. This behavior was explained by the pronounced directional self-assembly of the molecules, whereby the curvature effect of the capillary was negligible. The processing in nanoscopic pores of an inorganic membrane yielded an improved supramolecular organization. It was possible to remove the inorganic template and to obtain bundles and single nanorods. The templating over different dimensions opens a variety of potential applications. 相似文献
987.
Dr. Ashutosh Kumar Prof. Henrike Heise Dr. Marcel J. J. Blommers Dr. Philipp Krastel Dr. Esther Schmitt Dr. Frank Petersen Dr. Siva Jeganathan Dr. Eva‐Maria Mandelkow Dr. Teresa Carlomagno Prof. Christian Griesinger Prof. Marc Baldus 《Angewandte Chemie (International ed. in English)》2010,49(41):7504-7507
988.
Orianne Videau Marcel Delaforge Mikael Levi Etienne Thévenot Olivier Gal Laurent Becquemont Philippe Beaune Henri Bénech 《Rapid communications in mass spectrometry : RCM》2010,24(16):2407-2419
Phenotyping based on drug metabolism activity appears to be informative regarding mechanism‐based interactions during drug development. We report here the first steps of the development of the innovative CIME cocktail. This cocktail is designed not only for the major cytochrome P450, with caffeine, amodiaquine, tolbutamide, omeprazole, dextromethorphan and midazolam as substrates of CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A, respectively, but also phase II enzymes UGT 1A1/6/9 with acetaminophen, P‐gp and OATP1B1 with digoxin and rosuvastatin, and renal function with memantine. An assay combining ultra‐performance liquid chromatography using a 1.7 µm particle size column with tandem mass spectrometry (UPLC/MS/MS) was set up for the simultaneous quantification of the 20 substrates and metabolites after extraction from human plasma using solid‐phase extraction. The method was validated in the spirit of the FDA guidelines. Mean accuracy ranged from 87.7 to 115%, the coefficient of variance (CV%) of intra‐ and inter‐run from 1.7 to 16.4% and from 1.6 to 14.9%, respectively, and for the limit of quantification (LOQ) with ten lots of plasma, accuracy ranged from 84 to 115% and CV% precision was <16%. Short‐term stability was evaluated in eluate (4 h, room temperature), plasma (24 h, room temperature), the autosampler (24 h, 4°C) and in three freeze/thaw cycles in plasma. All except three analytes were stable under these conditions. For the three others a specific process can be followed. This robust, fast and sensitive assay in human plasma provides an analytical tool for ten‐probe drugs of the CIME cocktail. Clinical samples will be assayed in the near future using this new assay method. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
989.
We establish original Moser estimates to clarify and complete previous works of Christodoulou and Müller zum Hagen concerning local existence and uniqueness results for the Goursat problem associated to second order quasilinear hyperbolic systems. As an application we locally solve, in some weighted Sobolev spaces, the Goursat problem for the Einstein–Yang–Mills–Higgs system using harmonic and Lorentz gauges. 相似文献
990.
Marcel Erné 《Applied Categorical Structures》2007,15(5-6):541-572
We provide the appropriate common ‘(pre)framework’ for various central results of domain theory and topology, like the Lawson
duality of continuous domains, the Hofmann–Lawson duality between continuous frames and locally compact sober spaces, the
Hofmann–Mislove theorems about continuous semilattices of compact saturated sets, or the theory of stably continuous frames
and their topological manifestations. Suitable objects for the pointfree approach are quasiframes, i.e., up-complete meet-semilattices
with top, and preframes, i.e., meet-continuous quasiframes. We introduce the pointfree notion of locally compact well-filtered
preframes, show that they are just the continuous preframes (using a slightly modified definition of continuity) and establish
several natural dualities for the involved categories. Moreover, we obtain various characterizations of preframes having duality.
Our results hold in ZF set theory without any choice principles.
相似文献