全文获取类型
收费全文 | 1092篇 |
免费 | 48篇 |
国内免费 | 2篇 |
专业分类
化学 | 785篇 |
晶体学 | 13篇 |
力学 | 13篇 |
数学 | 66篇 |
物理学 | 265篇 |
出版年
2024年 | 2篇 |
2023年 | 16篇 |
2022年 | 37篇 |
2021年 | 38篇 |
2020年 | 47篇 |
2019年 | 62篇 |
2018年 | 53篇 |
2017年 | 36篇 |
2016年 | 63篇 |
2015年 | 45篇 |
2014年 | 103篇 |
2013年 | 110篇 |
2012年 | 69篇 |
2011年 | 69篇 |
2010年 | 38篇 |
2009年 | 29篇 |
2008年 | 44篇 |
2007年 | 32篇 |
2006年 | 30篇 |
2005年 | 29篇 |
2004年 | 31篇 |
2003年 | 20篇 |
2002年 | 20篇 |
2001年 | 15篇 |
2000年 | 8篇 |
1999年 | 11篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 8篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 8篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1939年 | 1篇 |
排序方式: 共有1142条查询结果,搜索用时 15 毫秒
31.
Hongwei Wu Zhao Chen Weijie Chi Anivind Kaur Bindra Long Gu Cheng Qian Bing Wu Bingbing Yue Guofeng Liu Guangbao Yang Liangliang Zhu Yanli Zhao 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(33):11541-11545
Developing molecules with high emission efficiency both in solution and the solid state is still a great challenge, since most organic luminogens are either aggregation‐caused quenching or aggregation‐induced emission molecules. This dilemma was overcome by integrating planar and distorted structures with long alkyl side chains to achieve DAπAD type emitters. A linear diphenyl–diacetylene core and the charge transfer effect ensure considerable planarity of these molecules in the excited state, allowing strong emission in dilute solution (quantum yield up to 98.2 %). On the other hand, intermolecular interactions of two distorted cyanostilbene units restrict molecular vibration and rotation, and long alkyl chains reduce the quenching effect of the π–π stacking to the excimer, eventually leading to strong emission in the solid state (quantum yield up to 60.7 %). 相似文献
32.
Navjeet Kaur 《Phosphorus, sulfur, and silicon and the related elements》2019,194(3):186-209
Nitrogen, oxygen, and sulfur containing heterocycles have a wide range of biological activities. Metal and nonmetal catalysts are used in organic reactions with high activity. New strategies have been developed for the preparation of heterocycles in the last decades. The metal and nonmetal catalyzed synthesis of heterocycles is becoming an important and highly rewarding protocol in organic synthesis. In this review article, the synthesis of seven and higher-membered S-heterocycles is presented with the application of metal and nonmetal catalysts for the period from 1968 to 2018. 相似文献
33.
Navjeet Kaur 《Journal of heterocyclic chemistry》2019,56(4):1141-1167
Some transformations are not possible with ground‐state reactions even in the presence of a catalyst; hence, they are performed under photochemical conditions. Electron transfer occurred even with the photochemical excitement of one molecule where redox reaction is not possible at the ground state. The side products were obtained from ground‐state reactions. For C─C bond formation during photochemical reactions, there was no requirement of any chemical activation of the substrates. Therefore, these reactions are presented here for the synthesis of three‐membered and four‐membered heterocycles in the context of sustainable processes. 相似文献
34.
Anjleena Malhotra Tejinder Kaur Ranju Bansal 《Journal of heterocyclic chemistry》2019,56(10):2902-2911
In the present study, novel 4‐aryloxyquinazoline derivatives were synthesized and screened for in vitro cytotoxicity on human cancer cell lines at 10 μM. Some of the synthesized compounds displayed moderate to significant and selective cytotoxic activity against various leukemia, melanoma, ovarian, breast, and colon cancer cell lines. (E)‐3‐(3,4‐Dimethoxyphenyl)‐1‐(4‐(quinazolin‐4‐yloxy)phenyl)prop‐2‐en‐1‐one ( 9b ) was the most potent compound among all with an average growth inhibition of 70% against leukemia cancer cell lines. The compound also produced strong inhibition (75%) of colon cancer cell lines with 42.58% lethality of HCT‐116 cell line. 相似文献
35.
Jatinder Kaur Atul Bhardwaj Frank Wuest 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(10):3326-3337
Live-cell imaging with fluorescent probes is an essential tool in chemical biology to visualize the dynamics of biological processes in real-time. Intracellular disease biomarker imaging remains a formidable challenge due to the intrinsic limitations of conventional fluorescent probes and the complex nature of cells. This work reports the in cellulo assembly of a fluorescent probe to image cyclooxygenase-2 (COX-2). We developed celecoxib-azide derivative 14 , possessing favorable biophysical properties and excellent COX-2 selectivity profile. In cellulo strain-promoted fluorogenic click chemistry of COX-2-engaged compound 14 with non/weakly-fluorescent compounds 11 and 17 formed fluorescent probes 15 and 18 for the detection of COX-2 in living cells. Competitive binding studies, biophysical, and comprehensive computational analyses were used to describe protein-ligand interactions. The reported new chemical toolbox enables precise visualization and tracking of COX-2 in live cells with superior sensitivity in the visible range. 相似文献
36.
Kumar M Kumar R Bhalla V Sharma PR Kaur T Qurishi Y 《Dalton transactions (Cambridge, England : 2003)》2012,41(2):408-412
A thiacalix[4]arene based fluorescent chemosensor 3 in the cone conformation has been synthesized and its recognition behaviour is evaluated toward various metal ions in mixed aqueous media. The chemosensor 3 showed high selectivity towards Fe(3+) ions by fluorescence quenching of excimer emission. Further, evaluation of the 3·Fe(3+) complex prepared in situ demonstrated great promise for the detection of the Fe(3+) ion in the presence of amino acids, blood serum and bovine serum albumin (BSA) solution. The compound 3 has suitable permeability into the PC3 cells and can be utilized as a Fe(3+) selective sensor in living cells (PC3 cells). 相似文献
37.
Navkiran Kaur Mansimran Khokhar Vaibhav Jain P. V. Bharatam Rajat Sandhir Rupinder Tewari 《Applied biochemistry and biotechnology》2013,171(2):417-436
Emergence of the multidrug-resistant pathogens has rendered the current therapies ineffective thereby, resulting in the need for new drugs and drug targets. The accumulating protein sequence data has initiated a drift from classical drug discovery protocols to structure-based drug designing. In the present study, in silico subtractive genomics approach was implemented to find a set of potential drug targets present in an opportunist bacterial pathogen, Acinetobacter baumannii (A. baumannii). Out of the 43 targets identified, further studies for protein model building and lead-inhibitor identification were carried out on two cell-essential targets, MurA and MurB enzymes (of A. baumannii designated as MurAAb and MurBAb) involved in the peptidoglycan biosynthesis pathway of bacteria. The homology model built for each of them was further refined and validated using various available programs like PROCHECK, Errat, ProSA energy plots, etc. Compounds showing activity against MurA and MurB enzymes of other organisms were collected from the literature and were docked into the active site of MurAAb and MurBAb enzymes. Three inhibitors namely, T6361, carbidopa, and aesculin, showed maximum Glide score, hydrogen bonding interactions with the key amino acid residues of both the enzymes and acceptable ADME properties. Furthermore, molecular dynamics simulation studies on MurAAb–T6361 and MurBAb–T6361 complexes suggested that the ligand has a high binding affinity with both the enzymes and the hydrogen bonding with the key residues were stable in the dynamic condition also. Therefore, these ligands have been propsed as dual inhibitors and promising lead compounds for the drug design against MurAAb and MurBAb enzymes. 相似文献
38.
Jebanathirajah JA Pittman JL Thomson BA Budnik BA Kaur P Rape M Kirschner M Costello CE O'Connor PB 《Journal of the American Society for Mass Spectrometry》2005,16(12):1985-1999
The use of a new electrospray qQq Fourier transform ion cyclotron mass spectrometer (qQq-FTICR MS) instrument for biologic applications is described. This qQq-FTICR mass spectrometer was designed for the study of post-translationally modified proteins and for top-down analysis of biologically relevant protein samples. The utility of the instrument for the analysis of phosphorylation, a common and important post-translational modification, was investigated. Phosphorylation was chosen as an example because it is ubiquitous and challenging to analyze. In addition, the use of the instrument for top-down sequencing of proteins was explored since this instrument offers particular advantages to this approach. Top-down sequencing was performed on different proteins, including commercially available proteins and biologically derived samples such as the human E2 ubiquitin conjugating enzyme, UbCH10. A good sequence tag was obtained for the human UbCH10, allowing the unambiguous identification of the protein. The instrument was built with a commercially produced front end: a focusing rf-only quadrupole (Q0), followed by a resolving quadrupole (Q1), and a LINAC quadrupole collision cell (Q2), in combination with an FTICR mass analyzer. It has utility in the analysis of samples found in substoichiometric concentrations, as ions can be isolated in the mass resolving Q1 and accumulated in Q2 before analysis in the ICR cell. The speed and efficacy of the Q2 cooling and fragmentation was demonstrated on an LCMS-compatible time scale, and detection limits for phosphopeptides in the 10 amol/muL range (pM) were demonstrated. The instrument was designed to make several fragmentation methods available, including nozzle-skimmer fragmentation, Q2 collisionally activated dissociation (Q2 CAD), multipole storage assisted dissociation (MSAD), electron capture dissociation (ECD), infrared multiphoton induced dissociation (IRMPD), and sustained off resonance irradiation (SORI) CAD, thus allowing a variety of MS(n) experiments. A particularly useful aspect of the system was the use of Q1 to isolate ions from complex mixtures with narrow windows of isolation less than 1 m/z. These features enable top-down protein analysis experiments as well structural characterization of minor components of complex mixtures. 相似文献
39.
The ring opening polymerization of L-lactide was studied in bulk using stannous octoate as initiator. In some experiments, triphenylphosphine, a Lewis base was also used as co-initiator. The polymerization was carried out at 130°C up to 29 h. The monomer was used after recrystallizing three times with dry toluene. Experiments were carried out using a wide range of monomer to initiator ratio. The averages and distributions of molar masses of resulting PLA have been determined by means of size exclusion chromatography, SEC. It is shown that the (mode, process) procedure of dispersion of the catalyst in polymerization system affects the molar mass distribution of the product as is evidenced by the bimodality or even trimodality observed in the SEC chromatograms. 相似文献
40.
The oxidation of organic compounds is of extreme importance in synthetic chemistry. The catalysts provide high selectivity towards the oxidation products employing with the oxidants. This review is not intended to give a complete survey of all oxidation catalysis reactions by different catalysts but rather to give a summary of some important catalytic oxidation reactions by different metal and non-metal based catalysts. 相似文献