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Mahesh Girkar Bruce Macleod Robert Moll 《The Journal of the Operational Research Society》1992,43(2):169-175
In this article we show that bottom-left guillotine placement of rectangles ordered by decreasing width in a fixed-width bin is not more than three times the height of an optimal placement. This bound is also true for bottom-left placement of rectangles without the guillotine constraints. Thus, bottom-left guillotine placement in which rectangles are ordered by decreasing width has the same worst case performance bound as bottom-left placement of rectangles without guillotine constraints. 相似文献
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Katharigatta N. Venugopala Pottathil Shinu Christophe Tratrat Pran Kishore Deb Raquel M. Gleiser Sandeep Chandrashekharappa Deepak Chopra Mahesh Attimarad Anroop B. Nair Nagaraja Sreeharsha Fawzi M. Mahomoodally Michelyne Haroun Mahmoud Kandeel Syed Mohammed Basheeruddin Asdaq Viresh Mohanlall Nizar A. Al-Shari Mohamed A. Morsy 《Molecules (Basel, Switzerland)》2022,27(9)
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives against the larvae of the mosquito Anopheles arabiensis, a vector of malaria. All compounds demonstrated insecticidal activity against mosquito larvae in a dose-dependent fashion. A preliminary study of the structure–activity relationship indicated that the electron-withdrawing substituent in the para position of the 4-phenyl-pyrimidinone moiety enhanced the molecules’ potency. A docking study of these derivatives revealed favorable binding affinity for the sterol carrier protein-2 receptor, a protein present in the intestine of the mosquito larvae. Being effective insecticides against the malaria-transmitting Anopheles arabiensis, 1,2,3-triazole-based pyrimidinones represent a starting point to develop novel inhibitors of insect growth regulators. 相似文献
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Mahesh GAIDHANE Ajay GHATOLE Kushal LANJEWAR Kishor HATZADE 《Turkish Journal of Chemistry》2020,44(6):1495
Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, clarifying models for physicochemical properties, pharmacokinetics, and therapeutic science. The present facile synthetic strategy can be a practical approach for incorporating polymeric carriers conjugated with drug moieties, either in the backbone of the polymer or as a terminal and pendant group on the polymer chains. 相似文献