全文获取类型
收费全文 | 614篇 |
免费 | 18篇 |
国内免费 | 3篇 |
专业分类
化学 | 494篇 |
晶体学 | 3篇 |
力学 | 23篇 |
数学 | 27篇 |
物理学 | 88篇 |
出版年
2024年 | 2篇 |
2023年 | 6篇 |
2022年 | 20篇 |
2021年 | 17篇 |
2020年 | 18篇 |
2019年 | 17篇 |
2018年 | 17篇 |
2017年 | 16篇 |
2016年 | 23篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 56篇 |
2012年 | 50篇 |
2011年 | 55篇 |
2010年 | 30篇 |
2009年 | 18篇 |
2008年 | 41篇 |
2007年 | 42篇 |
2006年 | 38篇 |
2005年 | 26篇 |
2004年 | 16篇 |
2003年 | 17篇 |
2002年 | 12篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1992年 | 4篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 7篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1969年 | 1篇 |
1958年 | 1篇 |
1957年 | 1篇 |
1955年 | 2篇 |
1954年 | 1篇 |
排序方式: 共有635条查询结果,搜索用时 15 毫秒
31.
Discovery of Cell‐Permeable Inhibitors That Target the BRCT Domain of BRCA1 Protein by Using a Small‐Molecule Microarray
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Zhenkun Na Sijun Pan Dr. Mahesh Uttamchandani Prof. Dr. Shao Q. Yao 《Angewandte Chemie (International ed. in English)》2014,53(32):8421-8426
BRCTs are phosphoserine‐binding domains found in proteins involved in DNA repair, DNA damage response and cell cycle regulation. BRCA1 is a BRCT domain‐containing, tumor‐suppressing protein expressed in the cells of breast and other human tissues. Mutations in BRCA1 have been found in ca. 50 % of hereditary breast cancers. Cell‐permeable, small‐molecule BRCA1 inhibitors are promising anticancer agents, but are not available currently. Herein, with the assist of microarray‐based platforms, we have discovered the first cell‐permeable protein–protein interaction (PPI) inhibitors against BRCA1. By targeting the (BRCT)2 domain, we showed compound 15 a and its prodrug 15 b inhibited BRCA1 activities in tumor cells, sensitized these cells to ionizing radiation‐induced apoptosis, and showed synergistic inhibitory effect when used in combination with Olaparib (a small‐molecule inhibitor of poly‐ADP‐ribose polymerase) and Etoposide (a small‐molecule inhibitor of topoisomerase II). Unlike previously reported peptide‐based PPI inhibitors of BRCA1, our compounds are small‐molecule‐like and could be directly administered to tumor cells, thus making them useful for future studies of BRCA1/PARP‐related pathways in DNA damage and repair response, and in cancer therapy. 相似文献
32.
Molecular Diversity - The oxidation of benzylic alcohol to corresponding aldehyde and ketone using N-chlorosuccinimide (NCS)–N,N-dimethylformamide (DMF) has been described. This method gives... 相似文献
33.
Nishtala Venkata Bharat Mahesh Chityala Bhargavi G. Pasala Vijay Kumar Basavoju Srinivas 《Molecular diversity》2020,24(4):1139-1147
Molecular Diversity - A series of new spirooxindolocarbamates 4a–l and 6a–d were synthesized by using the Betti reaction. All the target compounds were well characterized by IR, NMR and... 相似文献
34.
Saurabh Bhatia Rashita Makkar Tapan Behl Aayush Sehgal Sukhbir Singh Mahesh Rachamalla Vasudevan Mani Muhammad Shahid Iqbal Simona Gabriela Bungau 《Molecules (Basel, Switzerland)》2022,27(5)
Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, many structurally diverse drug products and their secondary metabolites have been isolated from marine sources. The drugs obtained from marine sources have displayed an exceptional potential in the management of a wide array of diseases, ranging from acute to chronic conditions. A beneficial role of marine drugs in human health has been recently proposed. The current review highlights various marine drugs and their compounds and role in the management of chronic diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular disorders, which has led to the development of new drug treatment approaches. 相似文献
35.
Mandipogula Mahesh Veladi Panduranga Girish Prabhu Roopesh Kumar L P. Venkata Ramana 《合成通讯》2017,47(7):716-721
A simple protocol involving metal-free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal-mediated extrusion of dihydrogen. The method is advantageous in terms of metal-free conditions, nonexpensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products. 相似文献
36.
M. Arul KumarSivasambu Mahesh V. Parameswaran 《International Journal of Plasticity》2011,27(6):962-981
A novel ‘stack’ model of a rate-independent polycrystal, which extends the ‘ALAMEL’ model of Van Houtte et al. (2005) is proposed. In the ‘stack’ model, stacks of N neighboring ‘ALAMEL’ domains collectively accommodate the imposed macroscopic deformation while deforming such that velocity and traction continuity with their neighbors is maintained. The flow law and consistency conditions are derived and an efficient solution methodology based on the linear programming technique is given. The present model is applied to study plastic deformation of an idealized two-dimensional polycrystal under macroscopically imposed plane-strain tension and simple shear constraints. Qualitative and quantitative variations in the predicted macroscopic and microscopic response with N are presented. The constraint on individual ‘ALAMEL’ domains diminishes with stack size N but saturates for large N. Computational effort associated with the present model is analyzed and found to be well within one order of magnitude greater than that required to solve the classical Taylor model. Furthermore, implementation of the consistency conditions is found to reduce computation time by at least 50%. 相似文献
37.
38.
39.
40.