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991.
Background
Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds have the same cell types, sensory transduction markers and synaptic proteins? In the present study we have used antisera directed against PLCβ2, α-gustducin, serotonin (5-HT), PGP 9.5 and synaptobrevin-2 to determine the percentages of taste cells expressing these markers in taste buds in both rodent species. We also determined the numbers of taste cells in the taste buds as well as taste bud volume.Results
There are significant differences (p < 0.05) between mouse and rat taste buds in the percentages of taste cells displaying immunoreactivity for all five markers. Rat taste buds display significantly more immunoreactivity than mice for PLCβ2 (31.8% vs 19.6%), α-gustducin (18% vs 14.6%), and synaptobrevin-2 (31.2% vs 26.3%). Mice, however, have more cells that display immunoreactivity to 5-HT (15.9% vs 13.7%) and PGP 9.5 (14.3% vs 9.4%). Mouse taste buds contain an average of 85.8 taste cells vs 68.4 taste cells in rat taste buds. The average volume of a mouse taste bud (42,000 μm3) is smaller than a rat taste bud (64,200 μm3). The numerical density of taste cells in mouse circumvallate taste buds (2.1 cells/1000 μm3) is significantly higher than that in the rat (1.2 cells/1000 μm3).Conclusion
These results suggest that rats and mice differ significantly in the percentages of taste cells expressing signaling molecules. We speculate that these observed dissimilarities may reflect differences in their gustatory processing.992.
Salvatore D'Aniello George H Fisher Enza Topo Gabriele Ferrandino Jordi Garcia-Fernàndez Antimo D'Aniello 《BMC neuroscience》2007,8(1):109
Background
NMDA (N-methyl-D-aspartic acid) is a widely known agonist for a class of glutamate receptors, the NMDA type. Synthetic NMDA elicits very strong activity for the induction of hypothalamic factors and hypophyseal hormones in mammals. Moreover, endogenous NMDA has been found in rat, where it has a role in the induction of GnRH (Gonadotropin Releasing Hormone) in the hypothalamus, and of LH (Luteinizing Hormone) and PRL (Prolactin) in the pituitary gland. 相似文献993.
Felipe J. Llanes-Estrada Tim Van Cauteren Ángel P. Martín 《The European Physical Journal C - Particles and Fields》2007,51(4):945-952
We study the multiple solutions of the truncated propagator Dyson–Schwinger equation for a simple fermion theory with Yukawa
coupling to a scalar field. Upon increasing the coupling constant g, other parameters being fixed, more than one non-perturbative
solution breaking chiral symmetry becomes possible and we find these numerically. These “recurrences” appear as a mechanism
to generate different fermion generations as quanta of the same fundamental field in an interacting field theory, without
assuming any composite structure. The number of recurrences or flavors is reduced to the question of the value of the Yukawa
coupling, and it has no special profound significance in the standard model. The resulting mass function can have one or more
nodes and the measurement that potentially detects them can be thought of as a collider-based test of the virtual dispersion
relation for the charged lepton member of each family. This requires the three independent measurements of the charged lepton’s energy,
three-momentum and off-shellness. We illustrate how this can be achieved for the (more difficult) case of the tau lepton.
PACS 12.15.Ff; 11.30.Rd 相似文献
994.
A zero modes’ Fock space is constructed for the extended chiral WZNW model. It gives room to a realization of the fusion ring of representations of the restricted quantum universal enveloping
algebra at an even root of unity, and of its infinite dimensional extension by the Lusztig operators We provide a streamlined derivation of the characteristic equation for the Casimir invariant from the defining relations
of A central result is the characterization of the Grothendieck ring of both and in Theorem 3.1. The properties of the fusion ring in are related to the braiding properties of correlation functions of primary fields of the conformal current algebra model.
相似文献
995.
We exhibit a Poisson module restoring a twisted Poincaré duality between Poisson homology and cohomology for the polynomial
algebra endowed with Poisson bracket arising from a uniparametrised quantum affine space. This Poisson module is obtained as the
semiclassical limit of the dualising bimodule for Hochschild homology of the corresponding quantum affine space. As a corollary
we compute the Poisson cohomology of R, and so retrieve a result obtained by direct methods (so completely different from ours) by Monnier.
This research of the first author was supported by a Marie Curie Intra-European Fellowship within the 6th European Community
Framework Programme. The second author was supported by EPSRC Grant EP/D034167/1. 相似文献
996.
Ebrahimi-Fard Kurusch José M. Gracia-Bondía Frédéric Patras 《Letters in Mathematical Physics》2007,81(1):61-75
The word problem for an arbitrary associative Rota–Baxter algebra is solved. This leads to a noncommutative generalization
of the classical Spitzer identities. Links to other combinatorial aspects are indicated.
相似文献
997.
Scaling symmetry of -type Drinfel’d–Sokolov hierarchy is investigated. Applying similarity reduction to the hierarchy, one can obtain the Schlesinger
equation with (n + 1) regular singularities. Especially in the case of n = 3, the hierarchy contains the three-wave resonant system and the similarity reduction gives the generic case of the Painlevé
VI equation. We also discuss Weyl group symmetry of the hierarchy.
相似文献
998.
A novel water-soluble solvatochromic molecule, 7-(dimethylamino)-2-fluorenesulfonate (2,7-DAFS), was prepared by a three-step
reaction from 2-nitrofluorene in good overall yield. The pH and solvent effects on the UV-VIS absorption and fluorescence
spectra of 2,7-DAFS have been studied. Protonation of the dimethylamino group switches the absorption from intramolecular
charge-transfer (ICT) to π → π* transition. The ground state pKa value of 2,7-DAFS was determined as 4.51. The fluorescence spectrum of the excited basic form, *(DAFS), shows a structureless
single band with a large Stokes shift, whereas that of the acidic form, *(+HDAFS), exhibits a structured band with a small Stokes shift. The emission intensities of the basic and acidic forms versus
pH/Ho plots show stretched sigmoidal curves and indicate that (1) the rate of deprotonation of *(+HDAFS) is comparable to the fluorescence decay of the species, and (2) the efficient proton-induced quenching of *(DAFS) fluorescence
occurs. The pKa* was estimated as −1.7 from the fluorescence titration curve. The fluorescence maximum of *(DAFS) is blue-shifted as the
polarity of solvent decreases. However, no clear dependency of the emission intensity and spectral half width, and thus fluorescence
quantum yield, on the solvent polarity was revealed. It appears that the fluorescence sensitivity of 2,7-DAFS is 15 ∼ 25 times
greater than the sensitivity of a widely utilized fluorescent probe, 5-(dimethylamino)-1-naphthalenesulfonate. This higher
sensitivity, together with the ease of derivatization, would provide the fluorene-based fluorescent molecules significant
advantages for a variety of applications. 相似文献
999.
Kalnina I Klimkane L Kirilova E Toma MM Kizane G Meirovics I 《Journal of fluorescence》2007,17(6):619-625
The fluorescent probe-aminoderivative of benzanthrone, ABM (developed at Riga Technical University, Riga, Latvia) was used
to characterize the membranes of lymphocytes of cancer patients: 46 patients with gastrointestinal diseases, 13 patients having
different primary localizations with massive metastases and intoxication. Patients were divided into three groups: (1) with
decreased fluorescence intensity, (2) normal fluorescence intensity, (3) increased fluorescence intensity. The lymphocytes
distribution among subsets differed between groups, in correspondence to the level of florescence intensity. Surgical treatment
affected the main immunological parameters and elevated the functional activity of lymphocytes. In the advanced tumors group,
fluorescence intensity correlates with the survival rate. Results suggest that determination of lymphocytes functional activity
by ABM can aid evaluation of the immune status in cancer patients. 相似文献
1000.
The value of intrinsic chlorophyll fluorescence polarization, and the intensity in emission spectrum were investigated in
leaf segments of Alocasia macrorrhiza under several stress conditions including different temperatures (25–50°C), various concentrations of NaCl (0–250 mM), methyl
viologen (MV, 0–25 μM), SDS (0–1.0%) and NaHSO3 (0–80 μM). Fluorescence emission spectrum of leaves at wavelength regions of 500–800 nm was monitored by excitation at 436 nm.
The value of fluorescence polarization (P value), as result of energy transfer and mutual orientation between chlorophyll molecules, was determined by excitation at
436 nm and emission at 685 nm. The results showed that elevated temperature and concentrations of salt (NaCl), photooxidant
(MV), surfactant (SDS) and simulated SO2 (NaHSO3) treatments all induced a reduction of fluorescence polarization to various degrees. However, alteration of the fluorescence
spectrum and emission intensity of F685 and F731 depended on the individual treatment. Increase in temperature and concentration of NaHSO3 enhanced fluorescence intensity mainly at F685, while an increase in MV concentration led to a decrease at both F685 and F731. On the contrary, NaCl and SDS did not cause remarkable change in fluorescence spectrum. Among different treatments, the
negative correlation between polarization and fluorescence intensity was found with NaHSO3 treatments only. We concluded that P value being measured with intrinsic chlorophyll fluorescence as probe in leaves is a susceptible indicator responding to
changes in environmental conditions. The alteration of P value and fluorescence intensity might not always be shown a functional relation pattern. The possible reasons of differed
response to various treatments were discussed. 相似文献