XPS研究聚苯胺的竞争掺杂行为

采用Ｘ射线光电子能谱（ＸＰＳ）方法对不同反应体系下化学合成的聚苯胺（ＰＡＮ）的结构和掺杂状况进行了研究。发现盐酸（ＨＣｌ）掺杂的聚苯胺在样品后处理过程中易发生脱掺杂行为;在十二烷基苯磺酸钠（ＳＤＢＳ）和盐酸共存体系下合成聚苯胺时,对阴离子ＤＢＳ＾－和Ｃｌ＾－发生竞争掺杂行为。结果表明ＤＢＳ＾－与带正电荷聚苯胺链结合,起到了掺杂和诱导聚苯胺可溶性的作用,它的Ｎ１ｓ和Ｓ２ｐ谱图与单独采用十二烷基苯磺酸     

The Interaction Between Hydrodynamic Nonpropagating Solitons

The interaction between hydrodynamic nonpropagating solitons in a water tank has been investigated within the framework of Larraza & Putterman and Miles theory. It is shown that these solitons, similar to one-dimensional boats, never pass through each other and exchange places, and thus their interaction can be described in terms of two-body potential. The interaction potential for two solitons with opposite polarity and that for solitons with like polarity are found to be pure repulsive and anharmonic, respectively. Based on the results, it is explained well why two solitons of an opposite pair repel each other as a distance is reached. while that of a like pair can oscillate about each other.     

衰荡腔复杂模拍效应的实验研究

利用光参量振荡器产生的脉冲光研究了衰荡腔在不同条件下的衰减信号,实验表明,衰荡腔的输出信号会呈现复杂的调制。这些现象,有些可利用在谐振腔本征模理论基础上导出的公式来解释,另外一些可能是由于像散和畸变引起的腔的横膜分裂,从而导致复杂的模拍效应,对实验结果进行了分析和解释。     

超临界LNG在错列S形翅片微通道的流动传热特性研究

作为一种新型微通道换热器,印刷电路板式换热器(Printed Circuit Heat Exchanger,PCHE)因比表面积大、耐高压和低温、海上适应性强以及便于模块化等特点,近年来逐渐成为浮式LNG接收站和浮式储存及再气化装置的主低温换热器首选.针对改进后的错列S型翅片,对超临界LNG在翅片通道内的流动传热特性展...     

Effect of Co-Treatment of Olanzapine with SEP-363856 in Mice Models of Schizophrenia

Olanzapine is a commonly used drug in the treatment of schizophrenia, but its clinical application has been restricted by metabolic-related side effects. In order to mitigate the weight gain side effects caused by olanzapine, other drugs with different targets were selected for combined use and evaluated in animal models of schizophrenia. SEP-363856 is a novel psychotropic agent which is under phase III clinical trials for schizophrenia treatment. The aim of the research was to evaluate whether co-administration of olanzapine and SEP-363856 exerts synergistic anti-schizophrenic effects in the apomorphine (APO)-induced climbing test, the MK-801-induced hyperactivity test, and the Morris water maze test, and therefore reduces the weight gain side effects induced by olanzapine. Through isobolographic analysis, the results showed a synergistic interaction in the climbing test; the experimental ED₃₀ (3 mg/kg) was significantly smaller (p < 0.05) than the theoretical ED₃₀ (5 mg/kg). Additionally, such potentiating effects appeared additive in the MK-801 challenge experiment. Co-treatment with an effective dose of olanzapine and a low dose of SEP-363856 reversed MK-801-induced cognitive impairment symptoms in mice. Moreover, combination treatment with olanzapine and SEP-363856 controls sustained weight gain in mice with chronic exposure to olanzapine. These results support further clinical trials to test the effectiveness of co-treatment of olanzapine and SEP-363856 for controlling symptoms and weight gain in patients with schizophrenia during antipsychotic treatments.     

An enhanced multi-term harmonic balance solution for nonlinear period-one dynamic motions in right-angle gear pairs

A nonlinear time-varying dynamic model for right-angle gear pair systems, considering both backlash and asymmetric mesh effects, is formulated. The mesh parameters that are characteristically time-varying and asymmetric include mesh stiffness, directional rotation radius and mesh damping. The period-one dynamic motions are obtained by solving the dimensionless equation of gear motion using an enhanced multi-term harmonic balance method (HBM) with a modified discrete Fourier Transform process and the numerical continuation method. The accuracy of the enhanced HBM solution is verified by comparison of its results to the more computational intensive, direct numerical integration calculations. Also, the Floquet theory is applied to determine the stability of the steady-state harmonic balance solutions. Finally, a set of parametric studies are performed to determine quantitatively the effects of the variation and asymmetry in mesh stiffness and directional rotation radius on the gear dynamic responses.     

A Journey from Benzoborirene to Benzoborole-Supported 1,2-Diimine and Antiaromatic Borolediide

The reaction of benzoborirene with one equivalent of isocyanides leads to benzene-fused boretes bearing one imine function, while the reaction with two equivalents of isocyanide affords 2,3-dihydro-2,3-diiminoboroles with perfect regioselectivity. The isocyanide double insertion products represent a novel type of 1,2-diimine with a benzoborole backbone. The reduction chemistry of the benzoborole-supported 1,2-diimine was investigated. Single- and two-electron reduction allow for the isolation and full characterization of a radical anion and a dianion, respectively. In stark contrast to the ordinary boroles, which should turn aromatic by accepting two electrons, the antiaromatic character of the benzoborole backbone is highlighted upon reduction, thus presenting a rare example of antiaromatic borole dianion. Detailed quantum chemical calculations provide a rationale for the observed regioselectivity and the electronic structure of the reduced borole diimine species.     

Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this method, the byproducts of carbon-nitrogen bond hydrogenolysis in traditional synthetic strategy can be completely avoided.     

Pharmacokinetics and tissue distribution of trans-ferulic acid-4-β-glucoside in rats using UPLC–MS/MS

Trans-ferulic acid-4-β-glucoside (FAG) is a monomer extracted from Radix Aconiti Lateralis Preparata, which is a potential candidate for the prevention and treatment of cold injury. To determine the concentration of FAG in rats, it is essential to develop an ultra-performance liquid chromatography coupled with MS/MS method. Chromatographic separation was achieved by an Acquity UPLC BEH C18 column (2.1 × 50 mm, 1.7 μm). A Xevo triple quadrupole tandem mass spectrometer was used to quantitatively determine FAG in the negative-ion mode. The standard calibration curve was linear over the concentration range of 0.1–100 μg/mL and 0.0626–31.28 μg/g for rat plasma and liver tissue homogenate samples, respectively. The inter- and intra-batch precision (% relative standard deviation) of the assay was ≤8.29%, and accuracy (% relative error) ranged from −7.41 to 10.99%. The matrix effect was between 92.99 and 102.39%. The oral absolute bioavailability of FAG was obtained as 1.80%. The results of tissue distribution suggested that FAG spread rarely in the liver and brown adipose, which was not propitious to exert its ability to treat cold injury. In general, these studies were significant to provide necessary information for further study.