Spectral-based color separation method for a multi-ink printer

A spectral-based 8-ink characterization model is developed to accurately predict the recipe for a multi-ink printer. The 8-ink color separation method is a union of five 3-ink and six 4-ink combinations based on the cellular Yule-Nielsen spectral Neugebauer model with a recipe selection strategy. The performance levels of the forward and backward models are evaluated for individual ink combinations using printed testing samples. Furthermore, the spectral-based method performs better compared with the XYZ-based approach. On the basis of the backward model performance, a novel fast recipe selection strategy is proposed and estimated.     

星形胶质细胞的动力学建模分析研究进展

越来越多的研究表明,星形胶质细胞作为神经系统中不可缺少的重要组成部分,和神经元之间有着密切的信息交流,对维持正常生命活动起着至关重要的作用.本文主要对目前星形胶质细胞动力学建模分析的相关研究进行综述.第1和第2部分阐述了星形胶质细胞的生理意义及在相关疾病中的作用;第3部分总结了星形胶质细胞的相关模型及动力学研究;第4部分总结了星形胶质细胞与神经元共建网络的相关模型及星形胶质细胞发挥作用的动力学研究;最后,第5部分对可进一步开展的工作进行了展望,指出对星形胶质细胞进行理论研究的下一步可能方向.     

Terpenoids from the Seeds of Toona sinensis and Their Ability to Attenuate High Glucose-Induced Oxidative Stress and Inflammation in Rat Glomerular Mesangial Cells

Toona sinensis (A. Juss.) Roem is an edible medicinal plant that belongs to the genus Toona within the Meliaceae family. It has been confirmed to display a wide variety of biological activities. During our continuous search for active constituents from the seeds of T. sinensis, two new acyclic diterpenoids (1–2), together with five known limonoid-type triterpenoids (3–7), five known apotirucallane-type triterpenoids (8–12), and three known cycloartane-type triterpenoids (13–15), were isolated and characterized. Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectra (HR-ESI-MS), and electronic circular dichroism (ECD), as well as the comparison with those reported in the literature. We compared these findings to those reported in the literature. Compounds 5, 8, and 13–14 were isolated from the genus Toona, and compounds 11 and 15 were obtained from T. sinensis for the first time. The antidiabetic nephropathy effects of isolated compounds against high glucose-induced oxidative stress and inflammation in rat glomerular mesangial cells (GMCs) were assessed in vitro. The results showed that new compounds 1 and 2 could significantly increase the levels of Nrf-2/HO-1 and reduce the levels of NF-κB, TNF-α, and IL-6 at concentrations of 30 μM. These results suggest that compounds 1 and 2 might prevent the occurrence and development of diabetic nephropathy (DN) and facilitate the research and development of new antioxidant and anti-inflammatory drugs suitable for the prevention and treatment of DN.     

软岩条件下大断面巷道支护技术的实践与研究

为进一步研究软岩条件下大断面巷道围岩的变形机制和破坏特征, 确定合理有效的支护形式和支护参数, 选取高家梁煤矿的大断面顺槽为研究对象, 在确定巷道断面形状和尺寸的基础上, 运用现场监测、数值模拟的方法, 确定了锚-网-索联合支护系统. 现场实践结果表明: 该支护形式和支护参数有效地控制了围岩的变形, 支护效果好, 经济合理, 安全可靠, 具有较高的应用价值, 此类支护系统为解决软岩内大断面巷道围岩变形大、稳定性差、巷道难以维护的问题提供了一条新思路.     

关于宽带和窄带超声血流速度测量方法的评价

本文对现有的几种超声血流速度测量方法做了细致的分析和计算机仿真研究,指出了各种方法的本质特点和他们之间的联系。理论分析和仿真的结果表明;脉冲多普勒方法和自相关法是本质上相同的两种窄带估计方法,由于它们对信号做的窄带假设与实际的信号有一定的差别,导致它们的估计性能较差;一方面不能充分利用多次回波的数据,另一方面还存在着严重的速度混叠现象,信号的频带愈宽,估计的效果愈差.时域互相关法、宽带极大似然法和二线傅氏变换法是三种宽带估计方法,其中时域互相关法和二维傅氏变换法结果上是完全相同的。宽带估计方法明显优于窄带方法,它们不仅有较高的速度分辨率并对速度混叠分量有很好的抑制作用,而且随着信号频带的增加和采样数据的延长,估计的质量还可以得到进一步的提高。     

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Hydrophobic tagging (HyT) is a potential therapeutic strategy for targeted protein degradation (TPD). Norbornene was discovered as an unprecedented hydrophobic tag in this study and was used to degrade the anaplastic lymphoma kinase (ALK) fusion protein by linking it to ALK inhibitors. The most promising degrader, Hyt-9 , potently reduced ALK levels through Hsp70 and the ubiquitin−proteasome system (UPS) in vitro without compensatory upregulation of ALK. Furthermore, Hyt-9 exhibited a significant tumor-inhibiting effect in vivo with moderate oral bioavailability. More importantly, norbornene can also be used to degrade the intractable enhancer of zeste homolog 2 (EZH2) when tagged with the EZH2 inhibitor tazemetostat. Thus, the discovery of novel hydrophobic norbornene tags shows promise for the future development of TPD technology.     

A Fused [5]Helicene Dimer with a Figure-Eight Topology: Synthesis,Chiral Resolution,and Electronic Properties

Chiral shape-persistent molecular nanocarbons are promising chiroptical materials; their synthesis, however, remains a big challenge. Herein, we report the facile synthesis and chiral resolution of a double-stranded figure-eight carbon nanobelt 1 in which two [5]helicene units are fused together. Two synthetic routes were developed, and, in particular, a strategy involving Suzuki coupling-mediated macrocyclization followed by Bi(OTf)₃-catalyzed cyclization of vinyl ether turned out to be the most efficient. The structure of 1 was confirmed by X-ray crystallographic analysis. The isolated (P,P)- and (M,M)- enantiomers show persistent chiroptical properties with relatively large dissymmetric factors (|g_abs|=5.4×10⁻³ and |g_lum|=1.0×10⁻²), which can be explained by the effective electron delocalization along the fully conjugated belt and the unique D₂ symmetry. 1 exhibits local aromatic character with a dominant structure containing eight Clar's aromatic sextet rings.