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63.
Jill C. D. S. Yaqub 《Geometriae Dedicata》1975,4(2-4):173-177
64.
Background
Propriospinal neurons, with axonal projections intrinsic to the spinal cord, have shown a greater regenerative response than supraspinal neurons after axotomy due to spinal cord injury (SCI). Our previous work focused on the response of axotomized short thoracic propriospinal (TPS) neurons following a low thoracic SCI (T9 spinal transection or moderate spinal contusion injury) in the rat. The present investigation analyzes the intrinsic response of cervical propriospinal neurons having long descending axons which project into the lumbosacral enlargement, long descending propriospinal tract (LDPT) axons. These neurons also were axotomized by T9 spinal injury in the same animals used in our previous study. 相似文献65.
Anhydroerythromycin A arises from the acid-catalysed degradation of erythromycin A both in vitro and in vivo. It has negligible antibacterial activity, but inhibits drug oxidation in the liver, and is responsible for unwanted drug-drug interactions. Its structure has 18 chiral centres common with erythromycin A, but C-9 (the spiro carbon) is also chiral in anhydroerythromycin and its stereochemistry has not previously been reported; both 9R- and 9S-anhydroerythromycin A are plausible structures. An understanding of the chirality at C-9 was expected to throw light on the mechanism of acid-catalysed degradation of erythromycin A, a subject that has been debated in the literature over several decades.We now report a determination of the three-dimensional structure of anhydroerythromycin A, including the stereochemistry at C-9, by NMR and molecular modelling. In parallel, the relative stereochemistry of anhydroerythromycin A 2'-acetate was determined by X-ray crystallography. Both compounds were shown to have 9R stereochemistry, and anhydroerythromycin A exhibited considerable conformational flexibility in solution. 相似文献
66.
Fragments of wall-paintings from Roman villas in Easton Maudit, which date from ca 150 AD have been studied by Raman spectroscopy.
An intact ancient Roman paint pot discovered in the remains of a villa in Castor, Cambridgeshire, still containing a mixture
of white and red pigment was also analysed and the pigments identified as haematite and anatase. The discovery of anatase
in the intact artist’s paint pot, particularly, and also on fragments of broken paint pots from the Easton Maudit villa site,
is a unique contribution to current knowledge of ancient European pigment history, because the presence of this mineral has
not hitherto been recognised fully in an ancient artist’s palette. The relative spectral response of anatase and haematite
in the Raman data is compared with that of anatase and other red pigments such as minium, cinnabar, and litharge. 相似文献
67.
Leanne Jill Rylands Don Shearman 《International Journal of Mathematical Education in Science & Technology》2018,49(8):1133-1147
This paper considers the effects of both free optional mathematics learning support and engagement on the mathematics performance in a foundation mathematics subject of a cohort of engineering students entering university with poor mathematical skills. New engineering students were directed to either a foundation or standard mathematics subject based on the results of a placement test. For students in the foundation subject, it was found that high levels of learning support were associated with greater improvement over the semester. Some form of learning support was used by 57.9% of the students, a reasonably high proportion of the cohort. Some factors for this high level of use of learning support are considered. One possible factor, the placement test, appears to have had a positive effect. Engagement in the subject activities as measured by tutorial attendance and learning management system use was found to have a positive association with final mark. Students who utilized a high level of learning support were more likely to be more engaged with the subject, making it impossible to draw conclusions about improvements being solely due to the use of learning support. 相似文献
68.
Jill Fielding-Wells 《ZDM》2018,50(7):1125-1138
An important use of statistical models and modeling in education stems from the potential to involve students more deeply with conceptions of distribution, variation and center. As models are key to statistical thinking, introducing students to modeling early in their schooling will likely support the statistical thinking that underpins later, more advanced work with increasingly sophisticated statistical models. In this case study, a class of 10–11 year-old students are engaged in an authentic task designed to elicit modeling. Multiple data sources were used to develop insights into student learning: lesson videotape, work samples and field notes. Through the use of dot plots and hat plots as data models, students made comparisons of the data sets, articulated the sources of variability in the data, sought to minimize the variability, and then used their models to both address the initial problem and to justify the effectiveness of their attempts to reduce induced variation. This research has implications for statistics curriculum in the early formal years of schooling. 相似文献
69.
We use a game theoretical approach to study pricing and advertisement decisions in a manufacturer–retailer supply chain when price discounts are offered by both the manufacturer and retailer. When the manufacturer is the leader of the game, we obtained Stackelberg equilibrium with manufacturer’s local allowance, national brand name investment, manufacturer’s preferred price discount, retailer’s price discount, and local advertising expense. For the special case of two-stage equilibrium when the manufacturer’s price discount is exogenous, we found that the retailer is willing to increase local advertising expense if the manufacturer increases local advertising allowance and provides deeper price discount, or if the manufacturer decreases its brand name investment. When both the manufacturer and retailer have power, Nash equilibrium in a competition game is obtained. The comparison between the Nash equilibrium and Stackelberg equilibrium shows that the manufacturer always prefers Stackelberg equilibrium, but there is no definitive conclusion for the retailer. The bargaining power can be used to determine the profit sharing between the manufacturer and the retailer. Once the profit sharing is determined, we suggest a simple contract to help the manufacturer and retailer obtain their desired profit sharing. 相似文献
70.