钴与5－Cl－PADAB反应机理及其应用的研究

对钴与４－［（５－氯－２－吡啶）偶氮］－１，３－二氨基苯（５－Ｃｌ－ＰＡＤＡＢ）形成络合物的吸收光谱进行探讨，结果表明：试剂及络合物在不同酸度条件下形成不同型体。在酸性条件下，络合物为大阳离子，钴离子以三价形式存在，钻与试剂的络合比为１：２。在强酸性介质中，将此络合物用于光度测定钻，方法选择性及稳定性好，且灵敏度极高。对水、粮食、土壤、茶叶及维生素Ｂ＿（１２）中微量钻进行直接测定，获得满意结果。     

A novel Np–Pu separation procedure based on extraction with di-(chlorophenyl)-dithiophosphinic acid in nitric solution

The extraction behavior of Pu(III), Pu(IV), Np(IV) and Np(V) with di(chlorophenyl)-dithiophosphinic acid (DCPDTPA) in toluene from nitric acid solutions was studied systematically. In aqueous solution with high nitric acid concentration, the extraction capability (represented by distribution ratio D) for Pu and Np in different valences with DCPDTPA comes as D _Np(IV) > D _Pu(IV) > D _Np(V) > D _Pu(III). A new radiochemical procedure for Np/Pu separation based on DCPDTPA extraction was proposed and tested with simulated samples. The recoveries of Np and Pu are as high as 80 % after the whole separation procedure, with the decontamination factor of trivalent lanthanide fission product element (e.g. Eu) greater than 1.5 × 10⁴. The decontamination factor of Pu–Np is 2.0 × 10³, while the decontamination factor of Np–Pu is greater than 4.8 × 10³ after additional purification.     

分析测试中取样单元数的确定——关于分析化学教材中取样问题的商榷

对武汉大学主编的《分析化学》（上册）第5版教材中关于取样单元数的计算进行了讨论,指出测量次数与采样单元数是不同的概念,在已知采样单元间的标准偏差估计值和允许误差的情况下,采样单元数应该用试差法求得。     

Combinatorial approach for the hydrothermal syntheses of open-framework zinc phosphates

Applying a combinatorial strategy, new zinc phosphates with interesting framework architectures have been hydrothermally synthesized and their structures solved by single-crystal X-ray diffraction analysis.     

Simultaneous Analysis of Avermectins in Bovine Tissues by LC-MS-MS with Immunoaffinity Chromatography Cleanup

A rapid, simple and sensitive LC-MS-MS method was developed to simultaneously measure residues of avermectin, ivermectin, doramectin, and eprinomectin in bovine liver and muscle. The extracted samples were cleaned by an immunoaffinity column which was prepared by coupling anti-avermectin polyclonal antibodies with CNBr-activated Sepharose 4B. The residues eluted from the column were analyzed by high-performance liquid chromatography with tandem mass spectrometry. Recoveries fortified at levels 5?50 ng g^?1 ranged from 62.93 to 84.03%, with relative standard deviations from 6.02 to 17.39% for all four compounds in liver tissue. The limits of quantification were 5 ng g^?1, and limits of detection were 2.5 ng g^?1 in liver for the four drugs. The procedure was also applied to bovine muscle, giving similar results.     

Celebrating 35 years of Chemical Research in Chinese Universities

The year of 2020 marks 35 years since the launch of Chemical Research in Chinese Universities.We take this opportunity to celebrate the 35 th anniversary of our journal with this special issue.Chemical Research in Chinese Universities is under the direct jurisdiction of the Ministry of Education and sponsored by Jilin University,which is a bi-monthly comprehensive research journal covering a variety of chemistry related subject areas.     

基于咔唑的新型碳酰腙衍生物的合成及蛋白酪氨酸磷酸酶1B(PTP1B)抑制活性评价

合成出了一系列新型基于咔唑的单-/双-碳酰腙衍生物3和4.利用1H NMR、13C NMR、IR和元素分析对其进行了结构表征.评价了目标化合物对蛋白酪氨酸磷酸酶1B(PTP1B)的抑制活性,讨论了结构与活性的关系.实验结果显示,大部分化合物对PTP1B具有良好的抑制活性,其中1,5-双[(9-丁基-3-咔唑基)亚甲基]碳酰腙(4c)的抑制活性最高,IC50=(4.81±0.41)mmol/L,且活性高于对照药物齐墩果酸.对目标化合物1-[(9-庚基-3-咔唑基)亚甲基]碳酰腙(3f)和4c进行分子对接研究和密度泛函理论(DFT)计算.分子对接结果表明,化合物3f和4c结合到PTP1B酶由螺旋α3和α6形成的活性位点,与PTP1B酶通过氢键、极性、疏水和p-p等相互作用形成了稳定的复合物.     

应用扫描电镜拉伸台测定激光熔覆层结合强度

采用扫描电镜的拉伸台测定了合金表面激光熔覆层与基体的结合强度，分析了基材预热温度对界面结合强度的影响，观察了界面裂纹的形成及扩展过程。结果表明，这种方法较为准确地测量了熔支与基体之间的结合强度。     

傅里叶变换用于铁和锌的同时光度测定

研究了傅里叶变换技术用于铁锌二组分的同时分光光度测定，采用傅里叶变换对吸光度数据进行预处理，再结合目标转换因子分析或偏最小二乘分析，结果较普通的目标转换因子分析或偏最小二乘法有显著改善。以傅里叶变换－偏最小二乘法就用于实际铝合金样品中铁和锌的同时测定，结果令人满意。     

Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury

Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease. Herein, we report the development of a molecular probe (LW-OTf) for the detection and imaging of two biomarkers involved in DILI. Initially, primary reactive oxygen species (ROS) superoxide (O₂˙⁻) selectively activates a near-infrared fluorescence (NIRF) output by generating fluorophore LW-OH. The C C linker of this hemicyanine fluorophore is subsequently oxidized by reactive nitrogen species (RNS) peroxynitrite (ONOO⁻), resulting in cleavage to release xanthene derivative LW-XTD, detected using two-photon excitation fluorescence (TPEF). An alternative fluorescence pathway can occur through cleavage of LW-OTf by ONOO⁻ to non-fluorescent LW-XTD-OTf, which can react further with the second analyte O₂˙⁻ to produce the same LW-XTD fluorescent species. By combining NIRF and TPEF, LW-OTf is capable of differential and simultaneous detection of ROS and RNS in DILI using two optically orthogonal channels. Probe LW-OTf could be used to detect O₂˙⁻ or O₂˙⁻ and ONOO⁻ in lysosomes stimulated by 2-methoxyestradiol (2-ME) or 2-ME and SIN-1 respectively. In addition, we were able to monitor the chemoprotective effects of tert-butylhydroxyanisole (BHA) against acetaminophen (APAP) toxicity in living HL-7702 cells. More importantly, TPEF and NIRF imaging confirmed an increase in levels of both O₂˙⁻ and ONOO⁻ in mouse livers during APAP-induced DILI (confirmed by hematoxylin and eosin (H&E) staining).

Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease.