Phytochemical analysis,antimicrobial, antioxidant and urease inhibitory potential of Cyphostemma digitatum Lam.

In this paper we report the antimicrobial, antiradical and urease inhibitory potential along with photochemical investigation of the crude extracts of Cyphostemma digitatum Lam. Phytochemical screening of both the crude (hot/cold) alcoholic and aqueous extracts of C. digitatum showed the presence of alkaloids, flavonoids, saponins, coumarins, steroids, terpenoids and tannins. The crude methanolic extract (hot/cold) exhibited good antioxidant activity, while the aqueous extract was a weak antioxidant. The crude methanolic extract was found to be more active against Bacillus subtilis, while both the extracts showed moderate antifungal potential, the methanolic crude extract showed good urease inhibitory activity compared with the aqueous crude extract.     

Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS,SARS-CoV,and SARS-CoV-2: A Reverse Vaccinology Approach

The continued emergence of human coronaviruses (hCoVs) in the last few decades has posed an alarming situation and requires advanced cross-protective strategies against these pandemic viruses. Among these, Middle East Respiratory Syndrome coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), and Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) have been highly associated with lethality in humans. Despite the challenges posed by these viruses, it is imperative to develop effective antiviral therapeutics and vaccines for these human-infecting viruses. The proteomic similarity between the receptor-binding domains (RBDs) among the three viral species offers a potential target for advanced cross-protective vaccine designs. In this study, putative immunogenic epitopes including Cytotoxic T Lymphocytes (CTLs), Helper T Lymphocytes (HTLs), and Beta-cells (B-cells) were predicted for each RBD-containing region of the three highly pathogenic hCoVs. This was followed by the structural organization of peptide- and mRNA-based prophylactic vaccine designs. The validated 3D structures of these epitope-based vaccine designs were subjected to molecular docking with human TLR4. Furthermore, the CTL and HTL epitopes were processed for binding with respective human Lymphocytes Antigens (HLAs). In silico cloning designs were obtained for the prophylactic vaccine designs and may be useful in further experimental designs. Additionally, the epitope-based vaccine designs were evaluated for immunogenic activity through immune simulation. Further studies may clarify the safety and efficacy of these prophylactic vaccine designs through experimental testing against these human-pathogenic coronaviruses.     

Analysis of Cattaneo–Christov theory for unsteady flow of Maxwell fluid over stretching cylinder

Journal of Thermal Analysis and Calorimetry - Analysis of thermal and solutal energy transport phenomena in Maxwell fluid flow with the help of Cattaneo–Christov double diffusion theory is...     

Thermal aspects of chemically reactive Oldroyd-B fluid flow over a rotating disk with Cattaneo–Christov heat flux theory

Journal of Thermal Analysis and Calorimetry - The current study explores the magnetized flow of an Oldroyd-B fluid by a rotating disk. In this analysis, we use the modified Fourier’s law...     

Design and optimization of a microwave photonic filter exploiting differential mode group delay of a multi-mode fiber

Optical Review - A reconfigurable and application-specific tunable microwave photonic filter having finite impulse response is proposed. The filter exploits the differential mode group delays of...     

Modified holographic dark energy in non-flat Kaluza–Klein universe with varying <Emphasis Type="Italic">G</Emphasis>

The purpose of this paper is to discuss the evolution of modified holographic dark energy with variable G in non-flat Kaluza–Klein universe. We consider the non-interacting and interacting scenarios of the modified holographic dark energy with dark matter and obtain the equation of state parameter through logarithmic approach. It turns out that the universe remains in different dark energy eras for both cases. Further, we study the validity of the generalized second law of thermodynamics in this scenario. We also justify that the statefinder parameters satisfy the limit of ΛCDM model.     

A dual Zariski topology for modules

We introduce a dual Zariski topology on the spectrum of fully coprime R-submodules of a given duo module M over an associative (not necessarily commutative) ring R. This topology is defined in a way dual to that of defining the Zariski topology on the prime spectrum of R. We investigate this topology and clarify the interplay between the properties of this space and the algebraic properties of the module under consideration.     

Bioconvection Due to Gyrotactic Microorganisms in Couple Stress Hybrid Nanofluid Laminar Mixed Convection Incompressible Flow with Magnetic Nanoparticles and Chemical Reaction as Carrier for Targeted Drug Delivery through Porous Stretching Sheet

In this paper, the steady electrically conducting hybrid nanofluid (CuO-Cu/blood) laminar-mixed convection incompressible flow at the stagnation-point with viscous and gyrotactic microorganisms is considered. Additionally, hybrid nanofluid flow over a horizontal porous stretching sheet along with an induced magnetic field and external magnetic field effects that can be used in biomedical fields, such as in drug delivery and the flow dynamics of the microcirculatory system. This investigation can also deliver a perfect view about the mass and heat transfer behavior of blood flow in a circulatory system and various hyperthermia treatments such as the treatment of cancer. The simple partial differential equations (PDEs) are converted into a series of dimensional ordinary differential equations (ODEs), which are determined using appropriate similarities variables (HAM). The influence of the suction or injection parameter, mixed convection, Prandtl number, buoyancy ratio parameter, permeability parameter, magnetic parameter, reciprocal magnetic prandtl number, bioconvection Rayleigh number, coupled stress parameter, thermophoretic parameter, Schmidt number, inertial parameter, heat source parameter, and Brownian motion parameter on the concentration, motile microorganisms, velocity, and temperature is outlined, and we study the physical importance of the present problem graphically.