Claisen-Umlagerung von 2-Propinyl-(3-pyridyl)-und Allyl-(3-pyridyl)äthern

Claisen Rearrangement of 2-Propinyl (3-Pyridyl) and Allyl (3-Pyridyl) Ethers

1 Verbindungen vom Typ 1 werden mit Ausnahme von 17 und 25 als Äther benannt. Der systematische Name von 1 ist: 3-(2-Propinyl)oxy-pyridin.

2-Propinyl (3-pyridyl) ether ( 1 ), synthesized from the corresponding 3-pyridinol, was heated in DMF or decane at 208° in a sealed tube. In this way the furopyridines 2 and 3 were formed, and furthermore the pyranopyridine 4 if decane was used as solvent (Scheme 1). The same reactions took place with (2-methyl-3-pyridyl) 2-propinyl ether ( 14 ). In DMF only 15 , and in decane 16 as well as 15 were formed (Scheme 3). The rearrangement of the pyridine derivative 17 , which is substituted in both O-positions to the ether moiety, gave in both DMF and decane the diastereoisomeric tetracyclic compounds 18 and 19 . The same kind of reaction took place with 25 (Scheme 4). In the thermolysis of the allyl 3-pyridyl ether ( 27 ) cyclization was observed, too. The isolated product has the structure of the dihydrofuropyridine 28 (Scheme 6). The substituted allyl 3-pyridyl ether 30 reacted in the same way to the dihydrofuropyridine 31 (Scheme 6).     

Third International Workshop on Imaging Techniques with Synchrotron Radiation

The Third International Workshop on Imaging Techniques with Synchrotron Radiation (ITSR2010) was held on November 6-9, 2010, in Suzhou near Shanghai, China, known as the “Chinese Venice.” This workshop follows two similar meetings held in 2008 and 2009 in Hefei and Sanya, respectively. The workshop hosted more than 60 delegates from 10 countries including China, Australia, the U.S, France, the U.K., Germany, Italy, Japan, Switzerland, Austria, and Ivory Coast. World-leading scientists presented some cutting-edge results as well as very stimulating topical reviews. The previous two meetings in Hefei and Sanya were conceived to bring experts together to help build up the user community of the recently developed Chinese synchrotron light sources in Hefei and Shanghai. The workshop in Suzhou witnessed the first, impressive results of this community, which has started using the novel facilities with enthusiasm. This series of meetings has established itself as one of the most relevant synchrotron imaging scientific meetings in China.     

Carotenoid response to retinal excitation and photoisomerization dynamics in xanthorhodopsin

We present a comparative study of xanthorhodopsin, a proton pump with the carotenoid salinixanthin serving as an antenna, and the closely related bacteriorhodopsin. Upon excitation of retinal, xanthorhodopsin exhibits a wavy transient absorption pattern in the region between 470 and 540 nm. We interpret this signal as due to electrochromic effect of the transient electric field of excited retinal on salinixanthin. The spectral shift decreases during the retinal dynamics through the ultrafast part of the photocycle. Differences in dynamics of bacteriorhodopsin and xanthorhodopsin are discussed.     

Topology Representing Networks for the Visualization of Manifolds

In practical data mining tasks, high-dimensional data has to be analyzed. In most of the cases it is very informative to map and visualize the hidden structure of a complex data set in a low-dimensional space. In this paper a new class of mapping algorithms is defined. These algorithms combine topology representing networks and different nonlinear mapping algorithms. While the former methods aim to quantify the data and disclose the real structure of the objects, the nonlinear mapping algorithms are able to visualize the quantized data in the low-dimensional vector space. In this paper, techniques based on these methods are gathered and the results of a detailed analysis performed on them are shown. The primary aim of this analysis is to examine the preservation of distances and neighborhood relations of the objects. Preservation of neighborhood relations was analyzed both in local and global environments. To evaluate the main properties of the examined methods we show the outcome of the analysis based both on synthetic and real benchmark examples.     

Characterization of californium sources by gamma spectrometry: relevance for nuclear forensics

As part of an experimental validation of a nuclear forensics methodology for Pu source reactor-type discrimination, destructive analysis has been performed on two irradiated UO₂ pellets with different irradiation histories. Analysis has focused on measuring key Sm fission product isotope ratios used in a previously published maximum likelihood methodology to determine the most likely irradiation history of the pellets. A total of 21 Sm isotope ratios were measured within the irradiated pellets, and generally agreed within 20% of the irradiations as simulated using the Monte Carlo Radiation Transport and material depletion code, MCNP6. Results indicate the chosen approach can accurately measure the isotope ratios within 5% experimental error.

     

A steroidal phenyldi­hydro‐1,3‐oxazine derivative

The structure of methyl (6R)‐6‐(3′β‐acetoxy‐5′‐androsten‐17′β‐yl)‐2‐phenyl‐5,6‐dihydro‐4H‐[1,3]oxazine, C₃₁H₄₁NO₃, synthesized from an azidopregnene derivative, is reported. The di­hydro‐1,3‐oxazine ring is connected in the β position to the sterane skeleton at C‐17′. An R configuration was found at C‐6.