4‐Hydro­xy‐3‐methoxy­benz­aldehyde 4,5‐di­azafluoren‐9‐yl­idene­hydrazone

The whole mol­ecule of the title compound, C₁₉H₁₄N₄O₂, is essentially planar, with a highly conjugated π system. In the crystal, the mol­ecules are packed as chains along the [011] direction connected by O—H?N intermolecular hydrogen bonds.     

A donor–acceptor compound composed of a di­nuclear zinc(II) complex of a Robson macro­cycle with 8‐methyl­quino­line

A donor–acceptor compound, di­aqua‐1κO,2κO‐[μ‐11,23‐dimethyl‐3,7,15,19‐tetra­aza­tri­cyclo­[19.3.1.1^9,13]hexacosa‐1(25),2,7,9,11,13(26),14,19,21,23‐decaene‐25,­26‐diolato‐1κ⁴N³,N⁷,O²⁵,O²⁶:­2κ⁴N¹⁵,N¹⁹,O²⁵,O²⁶]­dizinc(II) diperchlorate bis(8‐methyl­quinoline) ethanol disolvate, [Zn₂(C₂₄H₂₆N₄O₂)(H₂O)₂](ClO₄)₂·2C₁₀H₉N·2C₂H₆O, obtained by the reaction of a dinuclear zinc(II) complex of a Robson macrocycle (acceptor) and 8‐methyl­quinoline (donor), lies about an inversion centre and the coordination about the unique Zn atom is a distorted square pyramid. The fifth coordination site is occupied by the water mol­ecule, Zn—O = 2.016 (2) Å, and the average macrocyclic Zn—O and Zn—N distances are 2.059 (6) and 2.059 (3) Å, respectively.     

Selective Desorption of Intercalated Bovine Serum Albumin and Lysozyme by Organically Modified Montmorillonite

The organically modified montmorillonite (M‐Mt) was applied as an adsorbent for the purification of bovine serum albumin (BSA). In order to differentiate the selectivity and perform the purification of BSA, two kinds of proteins, BSA and lysozyme (LYZ) were mixed together and prepared at different pH, which could change the electrical charges on the surfaces of the proteins. BSA and LYZ can be adsorbed at the lower pH into the organically modified montmorillonite, which could be confirmed by powder X‐ray diffraction (XRD) in the d‐value increased after the adsorption of proteins. However, there is only BSA desorption was observed, approved by the method of Sodium dodecyl sulfate (SDS)‐polyacrylamide gel electrophoresis (PAGE), from this adsorbed protein mixture when the pH of the solution was adjusted and optimized. These results indicate that there is electrostatic interaction between a suitably modified montmorillonite and proteins BSA and LYZ to perform the selective desorption from BSA in the mixture of these proteins.     

Computer simulation to investigate absorption of energies of arrayed disk‐like nanoiron particles under magnetic fields

In this research, we focus on the studying of absorbed energies of materials under an external magnetic field frequency of 0.5 GHz. This wave corresponds to microwave irradiation. The absorbent materials were arrayed disk‐like iron particles with dimension on the nanometer scale and magnetic responses of the particles were simulated by solving the Landau–Lifshitz–Gilbert equation. The external fields were applied from various directions and energies of absorption of the system were calculated. The maximum absorbed energies were found when the field was 135° ± 30° along the X‐axis or the Y‐axis. The current simulation demonstrated that the direction of applied field results in different absorption energies of the system.     

A 3D‐QSAR Study of Celebrex‐Based Pdk1 Inhibitors Using Comfa Method

A 3D‐QSAR study of celebrex‐based compounds of PDK1 inhibitors using comparative molecular field analysis (CoMFA) was carried out. The structures of the compounds were obtained using quantum chemistry calculation. CoMFA calculations for a number of grouped subsets of compounds gave q² values of correlation in the range from 0 to 0.8. The low q² values should be mainly due to the narrow span of biological activity. Calculations for several subsets of 11–13 compounds gave high q² values, with 0.5–0.8. Factors affecting the results of the calculations are discussed. Calculated results with high q² values suggest that further chemical modifications of the compounds could lead to enhanced activity and could be an aid in the design of celebrex‐based cancer drugs.     

A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB)

This study provides an easy and simple method to obtain inorganic nanoparticles that can penetrate the blood-brain barrier, the heavily guarded system in the brain, via cross-linked serum albumin surface coatings. Their intact BBB permeability was confirmed in both in vitro and in vivo tests.     

A flow visualization study on self-ignition of high pressure hydrogen gas released into a tube

Hydrogen is known as one of the green energy sources for fuel cells and hydrogen-fueled cars in the next generation. The storage of high-pressure hydrogen gas conditions is preferred to its storage in cryogenic liquid state. However, cases of unidentified self-ignitions were reported, notably when the high-pressure hydrogen gas suddenly leaked out. Only a few of numerical simulations have shown visually the processes of the self-ignition inside a tube. This paper presents a flow visualization study to investigate the self-ignition mechanism in a test tube i.e. how the ignition process is initiated and the flame propagates. In addition to visualization, measurement of a number of pressure and light sensors installed in the tube supported the analysis of the self-ignition and flame propagation. The test result showed that self-ignition takes place at the boundary layer behind the front center of mixing zone at first, and the flame propagates to the front of mixing zone and tail of the mixing zone along the boundary layer. It showed that self-ignition is accompanied with complex mixing induced by shock interaction with the mixing front. It is also suggested that the self-ignition boundary has a certain critical threshold of static pressure at the boundary layer, based on various burst pressures of hydrogen.