High-Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water

We prepared a series of water-soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X-ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero-duplex as a tool to construct non-symmetrical dynamic supramolecular assemblies.     

Peptide analysis of tooth enamel – A sex estimation tool for archaeological,anthropological, or forensic research

Proteomics has become an attractive method to study human and animal material, biological profile, and origin as an alternative to DNA analysis. It is limited by DNA amplification in ancient samples and its contamination, high cost, and limited preservation of nuclear DNA. Currently, three approaches are available to estimate sex–osteology, genomics, or proteomics, but little is known about the relative reliability of these methods in applied settings. Proteomics provides a new, seemingly simple, and relatively non-expensive way of sex estimation without the risk of contamination. Proteins can be preserved in hard teeth tissue (enamel) for tens of thousands of years. It uses two sexually distinct forms of the protein amelogenin in tooth enamel detectable by liquid chromatography-mass spectrometry; the protein amelogenin Y isoform is present in enamel dental tissue only in males, while amelogenin isoform X can be found in both sexes. From the point of view of archaeological, anthropological, and forensic research and applications, the reduced destruction of the methods used is essential, as well as the minimum requirements for sample size.     

Synthesis and characterization of new pyrrolidinium based protic ionic liquids. Good and superionic liquids

New pyrrolidinium-cation-based protic acid ionic liquids (PILs) were prepared through a simple and atom-economic neutralization reactions between pyrrolidine and Br?nsted acids, HX, where X is NO 3 (-), HSO 4 (-), HCOO (-), CH 3COO (-) or CF 3COO (-) and CH 3(CH 2) 6COO (-). The thermal properties, densities, electrochemical windows, temperature dependency of dynamic viscosity and ionic conductivity were measured for these PILs. All protonated pyrrolidinium salts studied here were liquid at room temperature and possess a high ionic conductivity (up to 56 mS cm (-1)) at room temperature. Pyrrolidinium based PILs have a relatively low cost, a low toxicity and exhibit a large electrochemical window as compared to other protic ionic liquids (up 3 V). Obtained results allow us to classify them according to a classical Walden diagram and to determinate their "Fragility". Pyrrolidinium based PILs are good or superionic liquids and shows extremely fragility. They have wide applicable perspectives for fuel cell devices, thermal transfer fluids, and acid-catalyzed reaction media as replacements of conventional inorganic acids.     

Lamb wave propagation in a plate with a grooved surface with several spatial periodicities

In order to investigate non-destructively the bonding between rough plates, the problem of Lamb waves propagating on a rough plate is addressed in this paper. Numerical analysis is performed on periodical gratings made of identical triangular grooves. If the surface profile is made up of grooves with one periodicity, then a mode conversion is observed. In the wave-number/frequency space, a phonon relation is written between phonons related to the grating and to the incident and reflected-converted modes. If the grooved surface is made up of several spatial periodicities, then the phonon relation is still verified. Signal processing allows us to give an interpretation of the results in the dual space (wave-number/frequency). An experimental study is also performed to corroborate the numerical predictions.     

On the sensitivity analysis of porous material models

Porous materials are used in many vibroacoustic applications. Different available models describe their behaviors according to materials' intrinsic characteristics. For instance, in the case of porous material with rigid frame, and according to the Champoux–Allard model, five parameters are employed. In this paper, an investigation about this model sensitivity to parameters according to frequency is conducted. Sobol and FAST algorithms are used for sensitivity analysis. A strong parametric frequency dependent hierarchy is shown. Sensitivity investigations confirm that resistivity is the most influent parameter when acoustic absorption and surface impedance of porous materials with rigid frame are considered. The analysis is first performed on a wide category of porous materials, and then restricted to a polyurethane foam analysis in order to illustrate the impact of the reduction of the design space. In a second part, a sensitivity analysis is performed using the Biot–Allard model with nine parameters including mechanical effects of the frame and conclusions are drawn through numerical simulations.