Evolution on a Smooth Landscape: The Role of Bias

The role of mutational bias in evolution on a smooth landscape is investigated. We consider both a finite-length genome where the bias increases linearly with the fitness, and an infinite genome with a fixed bias. We present simulations of finite populations in a waiting time model, showing both the nonequilibrium dynamics and the equilibrium fitness distributions that are reached. We compute the equilibrium analytically in several cases, using approximate direct solution of the master equations and truncated hierarchies.     

Suppressing ringing caused by large photomultiplier tube signals

We describe here the characteristic features of the ringing we observed following large PMT signals in the Daya Bay reactor antineutrino experiment. We conclude that the ceramic capacitors used in the circuitry of the PMT bases and the HV-signal decouplers are the primary cause for this ringing. We present some possible schemes to reduce the ringing when replacing these ceramic capacitors is not feasible.     

Measurements of motionally averaged heteronuclear dipolar couplings in MAS NMR using R-type recoupling

A novel MAS NMR approach is presented for the determination of heteronuclear dipolar couplings in unoriented materials. The technique is based on the proton-detected local field (PDLF) protocol, and achieves dipolar recoupling by R-type radio-frequency irradiation. The experiment, which is called R-PDLF spectroscopy, is demonstrated on solid and liquid-crystalline systems. For mobile systems, it is shown that the R-PDLF scheme provides better dipolar resolution as compared to techniques combining conventional separated local field (SLF) spectroscopy with R-type recoupling.     

Evolution on a smooth landscape

We study in detail a recently proposed simple discrete model for evolution on smooth landscapes. An asymptotic solution of this model for long times is constructed. We find that the dynamics of the population is governed by correlation functions that although being formally down by powers ofN (the population size), nonetheless control the evolution process after a very short transient. The long-time behavior can be found analytically since only one of these higher order correlators (the two-point function) is relevant. We compare and contrast the exact findings derived herein with a previously proposed phenomenological treatment employing mean-field theory supplemented with a cutoff at small population density. Finally, we relate our results to the recently studied case of mutation on a totally flat landscape.     

Homo- and heteronuclear 2D NMR approaches to analyse a mixture of deuterated unlike/like stereoisomers using weakly ordering chiral liquid crystals

We describe several homo- and heteronuclear 2D NMR strategies dedicated to the analysis of anisotropic (2)H spectra of a mixture of dideuterated unlike/like stereoisomers with two remote stereogenic centers, using weakly orienting chiral liquid crystals. To this end, we propose various 2D correlation experiments, denoted "D(H)(n)D" or "D(H)(n)C" (with n=1, 2), that involve two heteronuclear polarization transfers of INEPT-type with one or two proton relays. The analytical expressions of correlation signals for four pulse sequences reported here were calculated using the product-operators formalism for spin I=1 and S=1/2. The features and advantages of each scheme are presented and discussed. The efficiency of these 2D sequences is illustrated using various deuterated model molecules, dissolved in organic solutions of polypeptides made of poly-gamma-benzyl-L-glutamate (PBLG) or poly-epsilon-carbobenzyloxy-L-lysine (PCBLL) and NMR numerical simulations.     

Physics opportunities with polarized e − and e + beams at TESLA

Beam polarization at e⁺-e^– linear colliders will be a powerful tool for high precision analyses. Often it is assumed that the full information from polarization effects is provided by polarization of the electron beam and no further information can be obtained by the simultaneous polarization of the positrons. In this paper we point out the advantages of polarizing both beams, and summarize the polarization-related results of the Higgs, Electroweak, QCD, SUSY and Alternative Theories working groups of the ECFA/DESY workshop for a planned linear collider operating in the energy range s = 500-800 GeV.     

FLASH—A superluminal communicator based upon a new kind of quantum measurement

The FLASH communicator consists of an apparatus which can distinguish between plane unpolarized (PUP) and circularly unpolarized (CUP) light plus a simple EPR arrangement. FLASH exploits the peculiar properties of measurements of the Third Kind. One purpose of this article is to focus attention on the operation of idealized laser gain tubes at the one-photon limit.FLASH: acronym for First Laser-Amplified Superluminal Hookup.