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11.
Rostami Mojtaba Aghajanzadeh Mozhgan Zamani Mostafa Manjili Hamidreza Kheiri Danafar Hossein 《Research on Chemical Intermediates》2018,44(3):1889-1904
Research on Chemical Intermediates - In this study, a kind of magnetic Fe3O4@mTiO2-GO (where m was shorted mesoporous) hybrids with core–shell nano-structure for controlled dual targeted drug... 相似文献
12.
A fast Pareto genetic algorithm approach for solving expensive multiobjective optimization problems 总被引:1,自引:0,他引:1
We present a new multiobjective evolutionary algorithm (MOEA), called fast Pareto genetic algorithm (FastPGA), for the simultaneous
optimization of multiple objectives where each solution evaluation is computationally- and/or financially-expensive. This
is often the case when there are time or resource constraints involved in finding a solution. FastPGA utilizes a new ranking
strategy that utilizes more information about Pareto dominance among solutions and niching relations. New genetic operators
are employed to enhance the proposed algorithm’s performance in terms of convergence behavior and computational effort as
rapid convergence is of utmost concern and highly desired when solving expensive multiobjective optimization problems (MOPs).
Computational results for a number of test problems indicate that FastPGA is a promising approach. FastPGA yields similar
performance to that of the improved nondominated sorting genetic algorithm (NSGA-II), a widely-accepted benchmark in the MOEA
research community. However, FastPGA outperforms NSGA-II when only a small number of solution evaluations are permitted, as
would be the case when solving expensive MOPs. 相似文献
13.
Alexander Malugin Heather Herd Hamidreza Ghandehari 《Journal of nanoparticle research》2011,13(10):5381-5396
The objective of this study was to evaluate the influence of size and surface functionality of amorphous silica nanoparticles
(SNPs) on their interaction with cultured cells. The intracellular uptake, phagocytic activity, and possible mechanisms of
toxicity induced by SNPs were studied on murine alveolar macrophages and two epithelial cancer cell lines. It was found that
phagocytic cells are more susceptible to amorphous SNPs than epithelial cells. SNPs with functionalized surfaces were capable
to induce the formation of apoptotic cells to a higher extent than plain particles. Plain SNPs induced plasma membrane damage
in phagocytic cells to a higher extent and caused cell death in a shorter period of time than surface-functionalized SNPs.
The prevalence of necrotic mode of cell death was observed after treatment with plain SNPs. In the range studied surface functionality
played an important role in SNPs toxicity. 相似文献
14.
Hamidreza Zolata Hossein Afarideh Fereydoun Abbasi-Davani 《Journal of Radioanalytical and Nuclear Chemistry》2014,301(2):451-460
In this research, we develop dual modality molecular imaging and also radio-immunotherapy (RIT) bioprobes, in the form of modified superparamagnetic iron oxide nanoparticles (SPIONs) conjugated to radiolabeled antibodies, for PET and MRI of HER2 expressing cancers as well as a PH sensitive drug carrier by embedded an anticancer agent for cancer therapeutic applications. The bioprobes were developed by conjugating 64Cu labeled trastuzumab (herceptin) and rituximab (Anti CD-20) antibodies to modified SPIONs. The SPIONs were modified with carboxymethyl chitosan and functionalized with acrylic acid (AA). Also, with the purpose of identifying more effective bifunctional chelator (BFC), we compared the properties of novel BFC, p-NO2-Bn-PCTA with the commonly used DOTA-NHS for radio-immunoconjugate preparations. Moreover, a chemotherapy drug, doxorubicin, was then loaded onto engineered nanoparticles for targeted intracellular drug delivery and selective cancer cell killing. Resulting radio-immunoconjugated-SPIONs were evaluated for molecular imaging and effective targeting of the HER2+ receptors in SKBR3 cell lines and breast tumor bearing Balb/C mice. Therefore, our biocompatible SPIONs could serve as a promising multifunctional theranostics nanoplatform in dual modality imaging guided RIT of HER2 overexpressing cancer applicable to drug delivery and controlled drug release for trigger both intrinsic and extrinsic pathways of apoptosis. 相似文献
15.
Farahany Saeed Nordin Nur Azmah Ghandvar Hamidreza 《Journal of Thermal Analysis and Calorimetry》2020,141(3):1109-1122
Journal of Thermal Analysis and Calorimetry - In situ composites are today being considered for industrial use, owing to the fewer production steps involved, lower production cost, and better... 相似文献
16.
Ali Bagheri Jonathan Yeow Hamidreza Arandiyan Jiangtao Xu Cyrille Boyer May Lim 《Macromolecular rapid communications》2016,37(11):905-910
The polymerization of the photocleavable monomer, o‐nitrobenzyl methacrylate (NBMA), is investigated using photoinduced electron/energy transfer reversible addition‐fragmentation chain transfer polymerization. The polymerizations under visible red (λ max = 635 nm, 0.7 mW cm−2) and yellow (λ max = 560 nm, 9.7 mW cm−2) light are performed and demonstrate rational evidence of a controlled/living radical polymerization process. Well‐defined poly(o‐nitrobenzyl methacrylate) (PNBMA) homopolymers with good control over the molecular weight and polymer dispersity are successfully synthesized by varying the irradiation time and/or targeted degree of polymerization. Chain extension of a poly(oligo(ethylene glycol) methyl ether methacrylate) macro‐chain transfer agent with NBMA is carried out to fabricate photocleavable amphiphilic block copolymers (BCP). Finally, these self‐assembled BCP rapidly dissemble under UV light suggesting the photoresponsive character of NBMA is not altered during the polymerization under yellow or red light. Such photoresponsive polymers can be potentially used for the remote‐controlled delivery of therapeutic compounds.
17.
Hamidreza Ghafouri Taleghani Hossein Fakhraiee Hossein Zare 《Polymer Science Series B》2017,59(6):741-748
Polyaniline-co-phenylenediamine (PAn/PDA) nanocomposite has been prepared in the aqueous medium using sodium dodecyl benzene sulfonate (DBSNa) and hydroxypropylcellulose (HPC) as a surfactant. The tests used in this research to characterize the products were SEM, TEM, FTIR, UV–Visible and TGA for morphology, particle size, chemical structure and stability. The results confirm that the spherical nanocomposites (40–90 nm) were formed with high thermal stability. It is shown in the results that the physicochemical properties of poly(alkyl substituted anilines) are depended on the substituent groups that are bonded to N-position. The prepared nanocomposites were then tested for the antibacterial properties against three pathogenic strains. The antibacterial properties of nanocomposites were investigated by disk diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentrations (MBC), and bactericidal kinetic methods. The disk diffusion result indicated that the diameter of the inhibition zones of PAn/PDA–HPC nanocomposite was 9, 11, and 10 mm against E. coli, P. aeruginosa, and S. aureus respectively. It was found that the value of MIC of PAn/PDA–HPC nanocomposite against E. coli, P. aeruginosa and S. aureus were 2.5, 1.25 and 2.5 mg/mL respectively. The evaluation results revealed the PAn/PDA–HPC nanocomposite exhibited excellent inhibitory activity against both gram-negative and gram-positive bacteria. 相似文献
18.
Aliabadi HM Landry B Bahadur RK Neamnark A Suwantong O Uludağ H 《Macromolecular bioscience》2011,11(5):662-672
Characterization of a polymer library engineered to enhance their ability to protect and deliver their nucleotide cargo to the cells is reported. The ζ-potential continuously increased with higher polymer:siRNA weight ratio, and the ζ-potential of lipid-modified polymers:siRNA complexes were higher than PEI2 at all ratios. At polymer:siRNA ratio of 1:1, all lipid-substituted polymers showed complete protection against degradation. Lipid-modified polymers significantly increased the cellular uptake of siRNA complexes and down-regulation of GAPDH and P-gp (max. 66% and 67%, respectively). The results indicate that hydrophobic modification of low molecular PEI could render this otherwise ineffective polymer to a safe effective delivery system for intracellular siRNA delivery and protein silencing. 相似文献
19.
New existing results for a system of nonlinear third-order differential equation via fixed point index 下载免费PDF全文
Chengbo Zhai Li Zhao Shunyong Li Hamidreza Marasi 《Journal of Applied Analysis & Computation》2018,8(6):1694-1706
By using fixed point index theory, we investigate a system of nonlinear third-order differential equation. We give some sufficient conditions for the existence of at least one or two positive solutions to the system of nonlinear third-order differential equation. As applications, we also present two examples to demonstrate the main results. 相似文献
20.
Hamidreza Bojari Azim Malekzadeh Mahnaz Ghiasi Ahmad Gholizadeh Ramin Azargohar Ajay Kumar Dalai 《Crystal Research and Technology》2013,48(6):355-362
Lanthanum oxide nanoparticles were synthesized via thermal decomposition method of the lanthanum nitrate in the presence of citric acid or starch as emulsifier. The effects of emulsifier and calcination temperature were investigated on the phase transformation and particle size distribution of the products. La2O3 nanoparticles were synthesized by drying lanthanum precursor and emulsifier solution, followed by calcination process at 600 and 900°C, respectively. Products were characterized by Fourier Transform Infrared (FT‐IR) spectroscopy, X‐ray diffraction (XRD), thermal analysis (TG/DTA) and nitrogen adsorption method (porous characteristics). The morphology of the samples analyzed using scanning electron microscopy (SEM). Average crystallite size of the products was calculated by XRD data and average particle size was measured from the TEM micrographs. Lanthanum dioxycarbonate in different forms of the tetragonal and monoclinic is crystallized in the presence of citric acid and starch during the calcination at 600°C, respectively. The hexagonal structure, however, is detected as the only crystalline phase formed by calcination at 900°C. 相似文献