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31.
Construction of Modified Carbon Paste Electrode for Highly Sensitive Simultaneous Electrochemical Determination of Trace Amounts of Copper (II) and Cadmium (II) 下载免费PDF全文
Abbas Afkhami Morteza Soltani‐Shahrivar Hamed Ghaedi Tayyebeh Madrakian 《Electroanalysis》2016,28(2):296-303
A chemically modified electrode was constructed for rapid, simple, accurate, selective and highly sensitive simultaneous determination of Cu(II) and Cd(II) using square wave anodic stripping voltammetry. The electrode was prepared by incorporation of SiO2 nanoparticles, coated with a newly synthesized Schiff base, in carbon paste electrode. The limit of detection was found to be 0.28 ng mL?1 and 0.54 ng mL?1 for Cu(II) and Cd(II), respectively. The proposed chemically modified electrode was used for the determination of copper and cadmium in several foodstuffs and water samples. 相似文献
32.
A suite of polymers were evaluated for their suitability as viable substrate materials for microchip electrophoresis applications, which were fabricated via replication technology. The relevant physiochemical properties investigated included the glass transition temperature (T(g)), UV-vis absorption properties, autofluorescence levels, electroosmotic flow (EOF) and hydrophobicity/hydrophilicity as determined by sessile water contact angle measurements. These physiochemical properties were used as a guide to select the proper substrate material for the intended microchip electrophoretic application. The T(g) of these polymers provided a guide for optimizing embossing parameters to minimize replication errors (REs), which were evaluated from surface profilometer traces. RE values ranged from 0.4 to 13.6% for the polymers polycarbonate (PC) and low-density polyethylene (LDPE), respectively. The absorption spectra and autofluorescence levels of the polymers were also measured at several different wavelengths. In terms of optical clarity (low absorption losses and small autofluorescence levels), poly(methyl methacrylate), PMMA (clear acrylic), provided ideal characteristics with autofluorescence levels comparable to glass at excitation wavelengths that ranged from 488-780 nm. Contact angle measurements showed a maximum (i.e., high degree of hydrophobicity) for polypropylene (PP), with an average contact angle of 104 degrees +/-3 degrees and a minimum exhibited by gray acrylic, G-PMMA, with an average contact angle of 27 degrees +/-2 degrees. The EOF was also measured for thermally assembled chips both before and after treatment with bovine serum albumin (BSA). The electrophoretic separation of a mixture of dye-labeled proteins including; carbonic anhydrase, phosphorylase B, beta-galactosidase, and myosin, was performed on four different polymer microchips using laser-induced fluorescence (LIF) excitation at 632.8 nm. A maximum average resolution of 5.04 for several peak pairs was found with an efficiency of 6.68 x 10(4) plates for myosin obtained using a BSA-treated PETG microchip. 相似文献
33.
Alberto Plaza Sonia Piacente Angela Perrone Arafa Hamed Cosimo Pizza Giuseppe Bifulco 《Tetrahedron》2004,60(52):12201-12209
Stemmosides C and D, two novel pregnane glycosides characterized by an unusual C-17 side chain were isolated from the pericarps of Solenostemma argel. In addition, stemmoside D displays an uncommon 14β proton configuration, apparently being the first pregnane isolated from plants known to have a 15 keto, cis CD ring junction. Their structures have been established by ESIMS and NMR experiments. The relative configuration of the molecules was determined using a strategy based on the simulation of 1H, 13C, and J coupling NMR parameters. DFT calculations of 1H and 13C chemical shifts, and of the 1H homonuclear spin–spin coupling constants were performed with the mPW1PW91 functional using the 6-31G(d,p) basis set on the fully optimized geometries of all the possible stereoisomers. 相似文献
34.
A simple, rapid, and sensitive RP-HPLC method using photodiode array detection was developed and validated for the simultaneous determination of granisetron hydrochloride, 1-methyl-1H-indazole-3-carboxylic acid (the main degradation product of granisetron), sodium benzoate, methylparaben, propylparaben, and 4-hydroxybenzoic acid (the main degradation product of parabens) in granisetron oral drops and solutions. The separation of the compounds was achieved within 8 min on a SymmetryShield RP18 column (100 x 4.6 mm id, 3.5 microm particle size) using the mobile phase acetonitrile--0.05 M KH2PO4 buffered to pH 3 using H3PO4 (3+7, v/v). The photodiode array detector was used to test the purity of the peaks, and the chromatograms were extracted at 240 nm. The method was validated, and validation acceptance criteria were met in all cases. The robust method was successfully applied to the determination of granisetron and preservatives, as well as their degradation products in different batches of granisetron oral drops and solutions. The method proved to be sensitive for determination down to 0.04% (w/w) of granisetron degradation product relative to granisetron and 0.03% (w/w) 4-hydroxybenzoic acid relative to total parabens. 相似文献
35.
The present work describes the construction of a new modified graphite-multiwall carbon nanotube paste electrode by casting the appropriate mixture of tetraheptylammonium iodide-iodine as a new modifier. The modified paste electrode was used for the determination of ascorbic acid (AA) in a phosphate buffer solution (pH 2.0). When compared to activated carbon, a graphite and multiwall carbon nanotube paste electrode containing a new modifier, the proposed modified paste electrode not only shifted the oxidation potential of AA towards a less-positive potential but also enhanced its oxidation peak current. Further, the oxidation of AA was highly stable at the modified paste electrode. The optimum analytical conditions were sought. The current response of AA increases linearly while increasing its concentration from 5.6 × 10(-5) to 1.2 × 10(-2) M with a correlation coefficient of 0.9991; the detection limit (3σ) was found to be of 3.6 × 10(-5) M. The present modified paste electrode was also successfully used for the determination of AA in the presence of common interference compounds. The present modified electrode was successfully demonstrated towards the determination of AA in pharmaceutical and food samples. 相似文献
36.
Mohamed Shaaban Marwa Y. Issa Mohamed A. Ghani Abdelaaty Hamed Ahmed B. Abdelwahab 《Natural product research》2019,33(1):24-33
During our continual searching programme for novel bioactive metabolites from Sarcophyton trocheliophorum, collected from Red Sea, we describe herein the isolation and structural elucidation of further two new pyrane-based cembranoid diterpenes: 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) and 8,9-expoy-sarcotrocheliol acetate (2), along with the well-known sarcotrocheliol acetate (3), (+)-sarcophine (4), (+)-sarcophytoxide (5) and (-)-sarcophytoxide (6). The chemical structures of compounds 1 and 2 were determined on the basis of 1D and 2D NMR (1H, 13C, 1H–1H COSY, HMQC, HMBC and NOE), mass spectra (ESI and HR-ESIMS) and by comparison with related structures. The antimicrobial activities of the reported compounds 1–6 were investigated. According to the molecular docking study of compounds 1–6 using 3D structure of α,β tubulin in complex with taxol (PDB code 1JFF) and epothilone A (PDB code 1TVK), sarcophine (4) displayed the highest affinity towards both crystal structures, followed by 5 and 6, meanwhile pyrane-based cembranoid diterpenes (1–3) showed less affinity. 相似文献
37.
Mohammed Hamed Alqarni Ahmed Ibrahim Foudah Magdy Mohamed Muharram Haritium Budurian Nikolaos E. Labrou 《Molecules (Basel, Switzerland)》2021,26(5)
The reactive adenosine derivative, adenosine 5′-O-[S-(4-hydroxy-2,3-dioxobutyl)]-thiophosphate (AMPS-HDB), contains a dicarbonyl group linked to the purine nucleotide at a position equivalent to the pyrophosphate region of NAD+. AMPS-HDB was used as a chemical label towards Candida boidinii formate dehydrogenase (CbFDH). AMPS-HDB reacts covalently with CbFDH, leading to complete inactivation of the enzyme activity. The inactivation kinetics of CbFDH fit the Kitz and Wilson model for time-dependent, irreversible inhibition (KD = 0.66 ± 0.15 mM, first order maximum rate constant k3 = 0.198 ± 0.06 min−1). NAD+ and NADH protects CbFDH from inactivation by AMPS-HDB, showing the specificity of the reaction. Molecular modelling studies revealed Arg174 as a candidate residue able to be modified by the dicarbonyl group of AMPS-HDB. Arg174 is a strictly conserved residue among FDHs and is located at the Rossmann fold, the common mononucleotide-binding motif of dehydrogenases. Arg174 was replaced by Asn, using site-directed mutagenesis. The mutant enzyme CbFDHArg174Asn was showed to be resistant to inactivation by AMPS-HDB, confirming that the guanidinium group of Arg174 is the target for AMPS-HDB. The CbFDHArg174Asn mutant enzyme exhibited substantial reduced affinity for NAD+ and lower thermostability. The results of the study underline the pivotal and multifunctional role of Arg174 in catalysis, coenzyme binding and structural stability of CbFDH. 相似文献
38.
M. Sh. Ramadan S. A. Senior G. M. Nabil E. A. Hamed 《Journal of Dispersion Science and Technology》2013,34(12):1752-1760
Reaction rate for alkaline hydrolysis of the substrates 3,5-dinitro-2-chloro benzotriflouride (DNCBTF) (1) at 30°C and 2,4-dinitrochloro benzene (DNCB) (2) at 50°C separetely with NaOH as nucleophile is carried out spectrophotometrically in mixed aqueous-acetonitrile solvents. In each system, cationic surfactant as dodecyltrimethyl ammonium bromide (DoTAB), or anionic one as sodium dodecyle sulfate (SDS) is used in wide range of concentrations to study the effect of micelle on the reaction rate. The micellar effect is explained in term of modified pseudo phase ion exchange model. Pseudo first order rate constant, kobs is obtained for each of the nucleophile and for both substrates 1 and 2 at all range of XAN · kobs at given [OH?] and in presence of any substrate is found to increase with the increase of DoTAB,while decrease with the increase of SDS as micellar phases. Critical micelle concentrations (CMCs) in similar trend are observed to increase in DoTAB while decrease in SDS systems by increasing acetonitrile (AN) content. Micellar binding constant (KS) between any type of given substrate and the formed micelle, is found to decrease in presence of DoTAB and increase in SDS micellar phases by increasing AN content. Finally, the ratios between pseudo first order rate constants for hydrolysis in micellar phase kM to that in the bulk phase kw for DoTAB and SDS systems are found to be greater than and smaller than unity respectively at any given XAN where the data indicated for (1) is always higher than those for (2). The results concluded that micelle DoTAB is working as a catalyst for the reaction rate, while that for SDS is considered as an inhibitor. 相似文献
39.
K. H. Hamed 《The European physical journal. Special topics》2009,174(1):65-79
Although persistence in natural data is generally admitted, its effect on the significance of various statistical tests has
not been extensively studied and is sometimes overlooked or simply ignored in practice. In particular, modified tests that
are robust in the presence of persistence are still lacking. In many situations, need may arise to test the significance of
correlation between two observed natural time series. Although the estimation of the classical product-moment correlation
coefficient is a straightforward task, classical significance testing depends on two major assumptions. The first assumption
is that the data are Gaussian, which is violated by many natural time series. In this case, a distribution-free measure of
correlation, such as Kendall’s tau should be used. The second, and often overlooked assumption, is that the observations in
each time series are not autocorrelated, which is also violated by most natural time series. Similar to the case of trend
testing (e.g. Mann-Kendall trend test), which has received some attention recently, the existence of persistence increases
the chance of falsely detecting significant correlation when the two series are actually uncorrelated. In this paper, the
effect of both short- and long-term persistence (STP and LTP) on the distribution of Kendall’s tau as a distribution-free
measure of correlation between two time series is investigated, and an exact expression for its variance under persistence
is derived. The implications of these results for the analysis of natural data are illustrated through the study of spurious
correlation between a 133-year Nile flow time series from A.D. 1871 to A.D. 2003 and independent segments of a reconstruction
of the North Hemisphere temperature time series from A.D. 1000 to A.D. 1980, both of which exhibit LTP. It is shown that spurious
significant correlation between completely unrelated segments of the two time series is on average three times as common as
in random series of the same length at the 10% significance level, which is consistent with the theoretical results. It is
also shown that accounting for LTP by using the correct variance of the test statistic effectively reduces the probability
of false identification to near its expected nominal value of 10%. Similar results were obtained at other significance levels. 相似文献
40.
A nonlinear finite element model is provided to predict the static aero-thermal deflection and the vibration behavior of geometrically imperfect shape memory alloy hybrid composite panels under the combined effect of thermal and aerodynamic loads. The nonlinear governing equations are obtained using Marguerre curved plate theory and the principle of virtual work taking into account the temperature-dependence of material properties. The effect of large deflection is included in the formulation through the von Karman nonlinear strain-displacement relations. The thermal load is assumed to be a steady-state constant-temperature distribution, whereas the aerodynamic pressure is modeled using the quasi-steady first-order piston theory. The Newton-Raphson iteration method is employed to obtain the nonlinear aero-thermal deflections, while an eigenvalue problem is solved at each temperature step and static aerodynamic load to predict the free vibration frequencies about the deflected equilibrium position. Finally, the nonlinear deflection and free vibration characteristics of a composite panel are presented, illustrating the effects of geometric imperfection, temperature rise, aerodynamic pressure, boundary conditions and shape memory alloy fiber embeddings on the panel response. 相似文献