Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease

The objective of this work was the application of peptidomics technologies for the detection and identification of reliable and robust biomarkers for Alzheimer's disease (AD) contributing to facilitate and further improve the diagnosis of AD. Using a new method for the comprehensive and comparative profiling of peptides, the differential peptide display (DPD), 312 cerebrospinal fluid (CSF) samples from AD patients, cognitively unimpaired subjects and from patients suffering from other primary dementia disorders were analysed as four independent analytical sets. By combination with a cross validation procedure, candidates were selected from a total of more than 6,000 different peptide signals based on their discriminating power. Twelve candidates were identified using mass-spectrometric techniques as fragments of the possibly neuroprotective neuroendocrine protein VGF and another one as the complement factor C3 descendent C3f. The combination of peptide profiling and cross validation resulted in the detection of novel potential biomarkers with remarkable robustness and a close relation to AD pathophysiology.     

On the epicomplete monoreflection of an archimedean lattice-ordered group

In a category C an object it G is epicomplete if the only epic monics out of G are isomorphisms, epic or monic meant in the categorical sense of right or left cancellable. For each of the categories Arch: archimedean ?-groups with ?-homomorphisms, and its companion category W: Arch-objects with distinguished weak unit and unit-preserving ?-homomorphisms, (and for the corresponding categories of vector lattices) epicompleteness has been characterized as divisible and conditionally and laterally σ-complete, and it has been shown to be monoreflective. Denote the reflecting functors by β and β ^W , respectively. What are they? For W the Yosida representation has been used to realize β ^W A as a certain quotient of B (Y A), the Baire functions on the Yosida space of A. For Arch, very little has been known. Here we give a general representation theorem, Theorem A, for β G as a certain subdirect product of W-epicomplete objects derived from G. That result, some W-theory, and the relation between epicity and relative uniform density are then employed to show Theorem B: β C _K (Y)=B _L (Y), where C _K (Y)is the ?-group of continuous functions on Y with compact support and B _L (Y) is the ?-group of Baire functions on Y having Lindelöf cozero sets.     

A three-level analytic model for alkali metal vapor lasers: part I. Narrowband optical pumping

A three-level analytic model for optically pumped alkali metal vapor lasers is developed by considering the steady-state rate equations for the longitudinally averaged number densities of the ground ²S_1/2 and first excited ²P_3/2, and ²P_1/2 states. The threshold pump intensity includes both the requirements to fully bleach the pump transition and exceed optical losses, typically about 200  W/cm². Slope efficiency depends critically on the fraction of incident photons absorbed and the overlap of pump and resonator modes, approaching the quantum efficiency of 0.95–0.98, depending on the alkali atom. For marginal cavity transmission losses, peak performance is achieved for low output coupling mirror reflectivity. For efficient operation, the collisional relaxation between the two upper levels should be fast to prevent bottlenecking. By assuming a statistical distribution between the upper two levels, the limiting analytic solution for the quasi two-level system is achieved. For properly designed gain conditions, the quasi two-level solution is usually achievable and represents ideal performance.     

An exact algorithm for graph partitioning

An exact algorithm is presented for solving edge weighted graph partitioning problems. The algorithm is based on a branch and bound method applied to a continuous quadratic programming formulation of the problem. Lower bounds are obtained by decomposing the objective function into convex and concave parts and replacing the concave part by an affine underestimate. It is shown that the best affine underestimate can be expressed in terms of the center and the radius of the smallest sphere containing the feasible set. The concave term is obtained either by a constant diagonal shift associated with the smallest eigenvalue of the objective function Hessian, or by a diagonal shift obtained by solving a semidefinite programming problem. Numerical results show that the proposed algorithm is competitive with state-of-the-art graph partitioning codes.     

Bregman operator splitting with variable stepsize for total variation image reconstruction

This paper develops a Bregman operator splitting algorithm with variable stepsize (BOSVS) for solving problems of the form $\min\{\phi(Bu) +1/2\|Au-f\|_{2}^{2}\}$ , where ? may be nonsmooth. The original Bregman Operator Splitting (BOS) algorithm employed a fixed stepsize, while BOSVS uses a line search to achieve better efficiency. These schemes are applicable to total variation (TV)-based image reconstruction. The stepsize rule starts with a Barzilai-Borwein (BB) step, and increases the nominal step until a termination condition is satisfied. The stepsize rule is related to the scheme used in SpaRSA (Sparse Reconstruction by Separable Approximation). Global convergence of the proposed BOSVS algorithm to a solution of the optimization problem is established. BOSVS is compared with other operator splitting schemes using partially parallel magnetic resonance image reconstruction problems. The experimental results indicate that the proposed BOSVS algorithm is more efficient than the BOS algorithm and another split Bregman Barzilai-Borwein algorithm known as SBB.     

Clean unital ℓ-groups

A ring with identity is said to be clean if every element can be written as a sum of a unit and an idempotent. The study of clean rings has been at the forefront of ring theory over the past decade. The theory of partially-ordered groups has a nice and long history and since there are several ways of relating a ring to a (unital) partially-ordered group it became apparent that there ought to be a notion of a clean partially-ordered group. In this article we define a clean unital lattice-ordered group; we state and prove a theorem which characterizes clean unital ?-groups. We mention the relationship of clean unital ?-groups to algebraic K-theory. In the last section of the article we generalize the notion of clean to the non-unital context and investigate this concept within the framework of W-objects, that is, archimedean ?-groups with distinguished weak order unit.     

Synthesis and physical properties of highly branched perfluorinated polymers from AB and AB2 monomers

Highly branched perfluorinated aromatic polyether copolymers were prepared from the polycondensation of the AB₂ monomer, 3,5‐bis[(pentafluorobenzyl)oxy]benzyl alcohol with a variety of fluoroaryl and alkyl bromide AB comonomers. The structures and comonomer distribution of the resulting polymers were characterized in detail. ¹H NMR data from kinetic trials illustrated that perfluoroaryl AB comonomer distribution correlated to AB comonomer sterics. ¹⁹F NMR data revealed that fluorinated AB monomers and 3‐bromo‐1‐propanol AB monomers were distributed within the AB₂ polymer backbone, while longer alkyl bromide AB monomers, 6‐bromo‐1‐hexanol, were mostly distributed along hyperbranched polymer chain ends. In general, as AB comonomer incorporation increased for nonsterically hindered copolymers, thermal decomposition onset increased and glass transition temperatures decreased. The combined data demonstrated the effect of comonomer distribution and sterics on physical properties of AB₂‐based polymer systems. The resulting materials were used to cast thin polymer films for measurement of contact angle, which were shown to be directly related to comonomer content. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 1880–1894     

Poly[N‐(10‐oxo‐2‐vinylanthracen‐9(10H)‐ylidene)cyanamide] as a novel cathode material for li‐organic batteries

Redox‐active polymers draw significant attention as active material in secondary batteries during the last decade. A new anthraquinone‐based redox‐active monomer was designed, which electrochemical behavior was tailored by mono‐modification of one keto group. The monomer exhibits two one‐electron redox reactions and has a low molar mass, resulting in a high theoretical capacity of 207 mAh/g. The polymerization of the monomer was optimized by variation of solvent and initiator. Moreover, the electrochemical behavior was studied using cyclic voltammetry and the polymer was used as active material in a composite electrode in lithium organic batteries. The polymer reveals a cell potential of 2.3 V and a promising capacity of 137 mAh/g. During the first 100 cycles, the capacity drops to 85% of the initial value. The influence of the charging speed on the charging/discharging properties of the batteries was further investigated. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 2517–2523     

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