Kinetics and products of the reaction of diazo compounds with SO2

Data were obtained on the composition of products and kinetics of the reaction of SO₂ with Ph(R)CN₂ (R=Ph, Me) in solutions of isooctane, 1,4-di-oxane, and ethanol at 295 K. A mechanism was proposed for the process in accordance with which the sulfene being formed participates in concurrent reactions with the starting reagents. The relative rate constants for the process stages were determined.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2496–2500, November, 1990.     

Accessibility of hydroxy groups of pectin substances for deuteration

An apparatus for the deuteration of solid samples and for recording their IR spectra in a current of D₂O vapor, and an IR-spectroscopic method of determining the degree of deuteration (q) of the hydroxy groups of pectin substances (PSs) are described. It has been established that there are no zones of structurally different nature in films of derivatives of PSs at the carboxy group. The rate of deuterium-exchange of the water of hydration of PSs is higher than for the hydroxy groups of the pyranose rings. The rate of deuterium exchange depends on the density of packing of the polymer chains of the pectin derivatives.Center for the Automation of Scientific Investigations and Metrology, Academy of Sciences of the Moldavian SSR, Kishinev. Translated from Khimiya Priorodnykh Soedinenii, No. 3, pp. 343–348, May–June, 1987.     

Über P–P-haltige cyclische Verbindungen. II

On P? P Containing Cyclic Compounds. II. Reaction of N,N'-dimethylthiourea with phenyl dichlorophosphane yields 1.4-dimethyl-2. 3-diphenyl-1.4.2.3-diazadiphospholidine-5-thione-2-sulfide ( II ). The compound is characterized by its nmr, vibration and mass spectra as well as the results of an X-ray structural analysis. Byproduct of the reaction is N-(N,N'-dimethylcarbamimidoyl)-N,N'-dimethyl thiourea hydrochloride ( III ), which crystallizes with pyridinium chloride. Molecular and crystal structure are reported. With methyl dichlorophosphane N,N'-dimethylthiourea forms 1.2.3.4-tetramethyl-1.4.2.3-diazadiphospholidine-5-thione-2-sulfide ( IV ), which is characterized by its nmr and vibration spectra.     

Researches on synthetic dyes

Reaction of phenyl-ß-naphthylamines with formaldehyde and acetone in the presence of HCl and nitrobenzene in butanol solution leads to cyclization involving the naphthalene and phenyl rings, and formation of N-aryllepidine salts. 15 lepidine and 5, 6-benzoepidine salts are synthesized and characterized by their UV absorption spectra, as well as by their picrates.For Part LIII see [3].     

Urinary excretion of methylated purines in man and in the rat after the administration of theophylline

Chromatographic characteristics of urinary metabolites of theophylline were studied by two-dimensional thin-layer chromatography, high-performance liquid chromatography and gas chromatography--mass spectrometry. Quantitative date for the urinary metabolites of theophylline in asthmatic children are given. It was shown that 1,3-dimethyluric acid is the predominant excretory product. In addition, smaller amounts of 1-methyluric acid, 3-methylxanthine and unchanged theophylline were found. Excretory patterns after theophylline ingestion before and during the administration of allopurinol in asthma patients and in rats suggest the existence of three metabolic pathways of theophylline. The administration of this drug to a patient with xanthine oxidase of theophylline. The administration of this drug to a patient with xanthine oxidase deficiency resulted in the excretion of 1-methyluric acid in addition to 1,3-dimethyluric acid, 3-methylxanthine, 1-methylxanthine and unchanged theophylline. It was concluded that in man the oxidation of theophylline is not catalysed by xanthine oxidase.