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21.
随着城市铁路系统的快速发展,铁路沿线建筑内人群对地铁运行产生噪声的抱怨逐渐增多,为控制室内地铁噪声对人群所产生的负面影响,有必要对地铁噪声产生的多维度负面情绪进行评估。采集了79名受试者对建筑内地铁噪声的多维度负面感受(压抑感,不舒适度和不满意度),基于偏最小二乘法分析了主客观影响因素对多维度负面感受的作用机制,并比较了多维度负面感受在反映地铁噪声影响上的差异。结果表明,多维度负面感受主要取决于主观响度和声学参数,活动干扰度、地铁噪声的敏感度、厌烦度和适应性的影响明显更弱;3个多维度负面感受中,相比于压抑感,不舒适度和不满意度受主观响度的影响轻微更显著,在相同的主观响度感受下,不满意度等级最高。 该文可以为地铁沿线建筑物内噪声负面感受的评价和改善提供参考。 相似文献
22.
Jinlong Cai Yongtong Xiong Xiang Zhu Jinyu Hu Yunping Wang Junkai Li Jianfeng Wu Qinglai Wu 《Molecules (Basel, Switzerland)》2022,27(15)
The Kleier model and Carrier-mediated theory are effective for molecularly designing pesticides with phloem mobility. However, the single Kleier model or Carrier-mediated theory cannot achieve a reliable explanation of the phloem mobility of all exogenous substances. A detailed investigation of the two models and the scope of their applications can provide a more accurate and highly efficient basis for the guidance of the design and development of phloem-mobile pesticides. In the present paper, a strategy using active ingredient-amino acid conjugates as mode compounds is developed based on Carrier-mediated theory. An N-alkylated amino acid is used to improve the pesticide’s physicochemical properties following the Kleier model, thus allowing the conjugates to fall on the predicted and more accessible transportation region of phloem. Moreover, the influence of this movement on phloem is inspected by the Kleier model and Carrier-mediated theory. To verify this strategy, a series of N-alkylated phenazine-1-carboxylic acid-glycine compounds (PCA-Gly) were designed and synthesized. The results related to the castor bean seeds (R. communis L.) indicated that all the target compounds (4a–4f) had phloem mobility. The capacity for phloem mobility shows that N-alkylated glycine containing small substituents can significantly improve PCA phloem mobility, such as 4c(i-C3H7-N) > 4a(CH3-N) ≈ 4b(C2H5-N) > 4d (t-C4H9-N) > PCA-Gly > 4e(C6H5-N) > 4f(CH2COOH-N), with an oil–water partition coefficient between 1.2~2.5. In particular, compounds 4a(CH3-N), 4b(C2H5-N), and 4c(i-C3H7-N) present better phloem mobility, with the average concentrations in phloem sap of 14.62 μΜ, 13.98 μΜ, and 17.63 μΜ in the first 5 h, which are 8 to 10 times higher than PCA-Gly (1.71 μΜ). The results reveal that the Kleier model and Carrier-mediated theory play a guiding role in the design of phloem-mobile pesticides. However, the single Kleier model or Carrier-mediated theory are not entirely accurate. Still, there is a synergism between Carrier-mediated theory and the Kleier model for promoting the phloem transport of exogenous compounds. Therefore, we suggest the introduction of endogenous plant compounds as a promoiety to improve the phloem mobility of pesticides through Carrier-mediated theory. It is necessary to consider the improvement of physicochemical properties according to the Kleier model, which can contribute to a scientific theory for developing phloem-mobile pesticides. 相似文献
23.
This paper investigates superconvergence properties of the local discontinuous Galerkin methods with generalized alternating fluxes for one-dimensional linear convection-diffusion equations. By the technique of constructing some special correction functions, we prove the(2k + 1)-th-order superconvergence for the cell averages, and the numerical traces in the discrete L~2 norm. In addition, superconvergence of orders k + 2 and k + 1 is obtained for the error and its derivative at generalized Radau points. All the theoretical findings are confirmed by numerical experiments. 相似文献
24.
Li Xiong Jin Hu Zhao Yang Xianglin Li Hang Zhang Guanhua Zhang 《Molecules (Basel, Switzerland)》2022,27(12)
This study presents the construction and dielectric properties investigation of atomic-layer-deposition Al2O3/TiO2/HfO2 dielectric-film-based metal–insulator–metal (MIM) capacitors. The influence of the dielectric layer material and thickness on the performance of MIM capacitors are also systematically investigated. The morphology and surface roughness of dielectric films for different materials and thicknesses are analyzed via atomic force microscopy (AFM). Among them, the 25 nm Al2O3-based dielectric capacitor exhibits superior comprehensive electrical performance, including a high capacitance density of 7.89 fF·µm−2, desirable breakdown voltage and leakage current of about 12 V and 1.4 × 10−10 A·cm−2, and quadratic voltage coefficient of 303.6 ppm·V−2. Simultaneously, the fabricated capacitor indicates desirable stability in terms of frequency and bias voltage (at 1 MHz), with the corresponding slight capacitance density variation of about 0.52 fF·µm−2 and 0.25 fF·µm−2. Furthermore, the mechanism of the variation in capacitance density and leakage current might be attributed to the Poole–Frenkel emission and charge-trapping effect of the high-k materials. All these results indicate potential applications in integrated passive devices. 相似文献
25.
Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases, including Alzheimer''s disease (AD), type II diabetes (T2D), and medullary thyroid carcinoma (MTC). While significant efforts have been made to develop different prevention strategies and preclinical hits for these diseases, conventional design strategies of amyloid inhibitors are mostly limited to either a single prevention mechanism (amyloid cascade vs. microbial infection) or a single amyloid protein (Aβ, hIAPP, or hCT), which has prevented the launch of any successful drug on the market. Here, we propose and demonstrate a new “anti-amyloid and anti-bacteria” strategy to repurpose two intestinal defensins, human α-defensin 6 (HD-6) and human β-defensin 1 (HBD-1), as multiple-target, dual-function, amyloid inhibitors. Both HD-6 and HBD-1 can cross-seed with three amyloid peptides, Aβ (associated with AD), hIAPP (associated with T2D), and hCT (associated with MTC), to prevent their aggregation towards amyloid fibrils from monomers and oligomers, rescue SH-SY5Y and RIN-m5F cells from amyloid-induced cytotoxicity, and retain their original antimicrobial activity against four common bacterial strains at sub-stoichiometric concentrations. Such sequence-independent anti-amyloid and anti-bacterial functions of intestinal defensins mainly stem from their cross-interactions with amyloid proteins through amyloid-like mimicry of β-sheet associations. In a broader view, this work provides a new out-of-the-box thinking to search and repurpose a huge source of antimicrobial peptides as amyloid inhibitors, allowing the blocking of the two interlinked pathological pathways and bidirectional communication between the central nervous system and intestines via the gut–brain axis associated with neurodegenerative diseases.Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases. Here, we proposed a new “anti-amyloid and anti-bacteria” strategy to repurpose two intestinal defensins as multiple-target, dual-function amyloid inhibitors. 相似文献
26.
Rui Li Xin Gou Xinyan Li Hainuo Wang Haibo Ruan Yuting Xiong Xianlun Tang Yuanyuan Li Ping-an Yang 《Molecules (Basel, Switzerland)》2022,27(15)
Flexible strain sensors, when considering high sensitivity and a large strain range, have become a key requirement for current robotic applications. However, it is still a thorny issue to take both factors into consideration at the same time. Here, we report a sandwich-structured strain sensor based on Fe nanowires (Fe NWs) that has a high GF (37–53) while taking into account a large strain range (15–57.5%), low hysteresis (2.45%), stability, and low cost with an areal density of Fe NWs of 4.4 mg/cm2. Additionally, the relationship between the contact point of the conductive network, the output resistance, and the areal density of the sensing unit is analyzed. Microscopically, the contact points of the conductive network directly affect the sensor output resistance distribution, thereby affecting the gauge factor (GF) of the sensor. Macroscopically, the areal density and the output resistivity of the strain sensor have the opposite percolation theory, which affects its linearity performance. At the same time, there is a positive correlation between the areal density and the contact point: when the stretching amount is constant, it theoretically shows that the areal density affects the GF. When the areal density reaches this percolation threshold range, the sensing performance is the best. This will lay the foundation for rapid applications in wearable robots. 相似文献
27.
基于LCVR调谐的全偏振多谱段成像系统 总被引:2,自引:0,他引:2
提出一种新型全偏振多谱段成像系统,将液晶相位可变延迟器LCVR应用于全偏振成像技术,在可见-近红外波段上可快速实现光的全偏振态的精确调制.系统由光学镜头、LCVR、偏振片、滤波片和CCD探测器组成.文章首先介绍了系统结构、工作原理和光学设计,并提出了适合本系统的偏振定标方法,建立了偏振定标系统,实现了利用较小面积的偏振... 相似文献
28.
Xia Ren Jiaying Xiong Lingzhi Liang Yin Chen Guisen Zhang 《Molecules (Basel, Switzerland)》2022,27(9)
Here, we explored the possible interaction between duloxetine and SEP-363856 (SEP-856) in depression-related reactions. The results showed that oral administration of duloxetine showed powerful antidepressant-like effects in both the forced swimming test (FST) and the suspension tail test (TST). SEP-856 orally administered alone also exerted an antidepressant-like effect in FST and TST, especially at doses of 0.3, 1, and 10 mg/kg. In addition, duloxetine (15 mg/kg) and SEP-856 (15 mg/kg) both showed antidepressant-like effects in the sucrose preference test (SPT). Most importantly, in the above experiments, compared with duloxetine alone, the simultaneous use of duloxetine and SEP-856 caused a more significant antidepressant-like effect. It is worth noting that doses of drug combination in FST and TST did not change the motor activities of mice in the open-field test (OFT). Thus, duloxetine and SEP-856 seem to play a synergistic role in regulating depression-related behaviors and might be beneficial for refractory depression. 相似文献
29.
We propose an efficient scheme to generate a macroscopical quantum superposition state with a cavity optomechanical system, which is composed of a quantum Rabi-Stark model coupling to a mechanical oscillator. In a low-energy subspace of the Rabi-Stark model, the dressed states and then the effective Hamiltonian of the system are given. Due to the coupling of the mechanical oscillator and the atom-cavity system, if the initial state of the atom-cavity system is one of the dressed states, the mechanical oscillator will evolve into a corresponding coherent state. Thus, if the initial state of the atom-cavity system is a superposition of two dressed states, a coherent state superposition of the mechanical oscillator can be generated. The quantum coherence and their distinguishable properties of the two coherent states are exhibited by Wigner distribution. We show that the Stark term can enhance significantly the feasibility and quantum coherence of the generated macroscopic quantum superposition state of the oscillator. 相似文献
30.
Coherent beam combination of adaptive fiber laser array with tilt-tip and phase-locking control 下载免费PDF全文
We present an experimental study on tilt-tip(TT) and phase-locking(PL) control in a coherent beam combination(CBC) system of adaptive fiber laser array.The TT control is performed using the adaptive fiber-optics collimator(AFOC),and the PL control is realized by the phase modulator(PM).Cascaded and simultaneous controls of TT and PL using stochastic parallel gradient descent(SPGD) algorithm are investigated in this paper.Two-fiber-laser-,four-fiber-laser-,and six-fiber-laser-arrays are employed to study the TT and PL control.In the cascaded control system,only one high-speed CMOS camera is used to collect beam data and a computer is used as the controller.In a simultaneous control system one high-speed CMOS camera and one photonic detector(PD) are employed,and a computer and a control circuit based on field programmable gate array(FPGA) are used as the controllers.Experimental results reveal that both cascaded and simultaneous controls of TT using AFOC and PL using PM in fiber laser array are feasible and effective.Cascaded control is more effective in static control situation and simultaneous control can be applied to the dynamic control system directly.The control signals of simultaneous PL and TT disturb each other obviously and TT and PL control may compete with each other,so the control effect is limited. 相似文献