Silylated derivatives of arabinonucleosides

Procedure have been developed which allow for the selective derivatization of arabinonucleosides at the 5′? or 2′? and 5′? or 3′? and 5′? positions.     

Ionization of aqueous dimethylbenzoic acids: Conductance and thermodynamics

Precise conductance measurements are reported for four xylic acids, 2,3-2,5-2,6 and 3,5-dimethylbenzoics. Limiting molar conductances Λ_O and pK _a obtained from a Fuoss type analysis, are reported for each of these acids at five degree intervals covering the range from 0° to 100°C. The Λ_O values for each acid are described by a polynomial in the Celsius temperature. The pK _a were smoothed as a function of the Kelvin temperature T with an equation of the form: $$pK_{\text{a}} = A{\text{ }} + {\text{ }}B/T{\text{ }} + {\text{ }}C{\text{ }}logT{\text{ }} + {\text{ }}DT$$ where the term linear in T was required only for the 2,3-acid. Standard enthalpy, entropy, and heat capacity changes were calculated by suitable differentiation of this equation. Walden products were calculated for the four anions at each of the temperatures and are compared with earlier data for the toluate and the benzoate ions. Those acids with ortho groups undergo a large decrease in enthalpy on ionization and are substantially more acidic than benzoic acid. These effects are especially large for 2,6-dimethylbenzoic acid. A methyl group in the meta position lowers acidity slightly both in m-toluic and in 2,5-dimethylbenzoic acid. However, 2,3-dimethylbenzoic acid is more acidic than o-toluic.     

Conformal field theory interpretation of black hole quasinormal modes

We obtain exact expressions for the quasinormal modes of various spin for the Ba?ados-Teitelboim-Zanelli black hole. These modes determine the relaxation time of black hole perturbations. Exact agreement is found between the quasinormal frequencies and the location of the poles of the retarded correlation function of the corresponding perturbations in the dual conformal field theory. This then provides a new quantitative test of the anti-de Sitter/conformal field theory correspondence.     

An efficient direct approach for computing shortest rectilinear paths among obstacles in a two-layer interconnection model

In this paper, we present a direct approach for routing a shortest rectilinear path between two points among a set of rectilinear obstacles in a two-layer interconnection model that is used for VLSI routing applications. The previously best known direct approach for this problem takes O(nlog²n) time and O(nlogn) space, where n is the total number of obstacle edges. By using integer data structures and an implicit graph representation scheme (i.e., a generalization of the distance table method), we improve the time bound to O(nlog^3/2n) while still maintaining the O(nlogn) space bound. Comparing with the indirect approach for this problem, our algorithm is simpler to implement and is probably faster for a quite large range of input sizes.     

Natural and Synthetic Oligoarylamides: Privileged Structures for Medical Applications

The term “privileged structure” refers to a single molecular substructure or scaffold that can serve as a starting point for high-affinity ligands for more than one receptor type. In this report, a hitherto overlooked group of privileged substructures is addressed, namely aromatic oligoamides, for which there are natural models in the form of cystobactamids, albicidin, distamycin A, netropsin, and others. The aromatic and heteroaromatic core, together with a flexible selection of substituents, form conformationally well-defined scaffolds capable of specifically binding to conformationally well-defined regions of biomacromolecules such as helices in proteins or DNA often by acting as helices mimics themselves. As such, these aromatic oligoamides have already been employed to inhibit protein–protein and nucleic acid–protein interactions. This article is the first to bring together the scattered knowledge about aromatic oligoamides in connection with biomedical applications.     

Comprehensive Bayesian analysis of rare (semi)leptonic and radiative \varvec{B} decays

The available data on \(|\Delta B| = |\Delta S| = 1\) decays are in good agreement with the Standard Model when permitting subleading power corrections of about \(15\,\%\) at large hadronic recoil. Constraining new-physics effects in \(\mathcal {C}_{7}^{\mathrm {}}\) , \(\mathcal {C}_{9}^{\mathrm {}}\) , \(\mathcal {C}_{10}^{\mathrm {}}\) , the data still demand the same size of power corrections as in the Standard Model. In the presence of chirality-flipped operators, all but one of the power corrections reduce substantially. The Bayes factors are in favor of the Standard Model. Using new lattice inputs for \(B\rightarrow K^*\) form factors and under our minimal prior assumption for the power corrections, the favor shifts toward models with chirality-flipped operators. We use the data to further constrain the hadronic form factors in \(B\rightarrow K\) and \(B\rightarrow K^*\) transitions.     

Chemoselective Intermolecular α‐Arylation of Amides

A new approach for the fully chemoselective α‐arylation of amides is presented. By means of electrophilic amide activation, aryl groups can be regioselectively introduced α‐ to amides, even in the presence of esters and alkyl ketones. Mechanistic studies reveal key reaction intermediates and emphasize a remarkably subtle base effect in this transformation.