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101.
Steffen Gebhardt Stefan Bihler Manfred Schubert‐Zsilavecz Sergio Riva Daniela Monti Laura Falcone Bruno Danieli 《Helvetica chimica acta》2002,85(7):1943-1959
A series of specific derivatives of the complex protopanaxadiol glycoside ginsenoside Rb1 ( 1 ) were prepared by catalysis of two unrelated enzymes: the β‐1,4‐galactosyltransferase from bovine colostrum (GalT) and the lipase B from Candida antarctica (Novozym ® 435). Both of the enzymes showed the expected regioselectivity towards specific glucose OH groups (i.e., OH C(4) for GalT and preferentially the primary OH C(6) for Novozym ® 435), accompanied by a nonpredictable ‘site selectivity' for the gentiobiose disaccharide unit linked at C(20) of the dammarane skeleton. The galactosylated products 1a – e and the acetylated products 1f – h were isolated by HPLC and fully characterized by extensive MS and NMR analysis. 相似文献
102.
103.
Luca Banfi Andrea Basso Chiara Lambruschini Lisa Moni Renata Riva 《Chemical science》2021,12(47):15445
This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction. After being nearly neglected for many years, now this reaction has become quite popular, thanks to the achievements of the last 30 years, which have revealed several chances of exploitation in organic synthesis. Though not being comprehensive, this review means to show the various ways that have been used in order to expand the utility of the Passerini reaction. Post-MCR transformations to give heterocycles or peptidomimetics, variants through single component replacement, stereochemical issues, and applications in total syntheses will be especially covered.This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction. 相似文献
104.
de la Riva H Nieuwhuyzen M Mendicute Fierro C Raithby PR Male L Lagunas MC 《Inorganic chemistry》2006,45(4):1418-1420
Changes in the optical properties of an alkynyldigold(I) complex upon reaction with Cu(I) are associated with a complicated structural change to form an unusual Au4Cu2 cluster with metallophilic interactions as well as pi-alkyne coordination. 相似文献
105.
Emanuela Bianchi Janetti Ishai Dror Monica Riva Alberto Guadagnini Xavier Sanchez-Vila Brian Berkowitz 《Transport in Porous Media》2013,97(3):295-315
We study the mobility and interaction under competing conditions observed for copper ( $\text{ Cu}^{2+}$ ) and zinc ( $\text{ Zn}^{2+}$ ) ions in the context of laboratory-scale experiments performed in natural soil columns. The experiments focus on the analysis of solute breakthrough curves (BTCs) obtained after injection of an aqueous solution containing similar concentrations of the two metal ions into a soil column fully saturated with double deionized water. Transport of the competing ions is tested for the same soil under aerobic and anaerobic conditions. Measurements show that the species with lower affinity for the soil, $\text{ Zn}^{2+}$ , migrates occupying all available adsorption sites, and is then progressively replaced by the ion with higher affinity, $\text{ Cu}^{2+}$ . The two ions are displaced in the system with different effective retardation. The slowest species replaces the sorbed ions, resulting in observed $\text{ Zn}^{2+}$ concentrations that display a non-monotonic behavior in time and which, for a certain period, are larger than the concentration supplied continuously at the inlet. In the absence of a complete geochemical characterization of the system, we show that the measured concentrations of both metals can be interpreted through simple models based on a set of coupled partial differential and algebraic equations, involving a small subset of aqueous and adsorbed species that are present in the system. Depending on the model considered, the relationship between aqueous and adsorbed ion concentrations is described at equilibrium by a Gaines–Thomas (GT) formulation, a competitive Sheindorf–Rebhun–Sheintuch (SRS) isotherm, or an Extended Langmuir (EL) isotherm, respectively. The GT formulation provides the best interpretation of the observed behavior among the models tested. We find that employing these simple models, which account only for the main governing reactive processes, allows reasonable estimation of the observed BTCs in experiments where only partial geochemical datasets are available. 相似文献
106.
Prof. Francesca Caterina Izzo Matilde Kratter Dr. Austin Nevin Prof. Elisabetta Zendri 《ChemistryOpen》2021,10(9):904-921
Up to 70 % of the oil paintings conserved in collections present metal soaps, which result from the chemical reaction between metal ions present in the painted layers and free fatty acids from the lipidic binders. In recent decades, conservators and conservation scientists have been systematically identifying various and frequent conservation problems that can be linked to the formation of metal soaps. It is also increasingly recognized that metal soap formation may not compromise the integrity of paint so there is a need for careful assessment of the implications of metal soaps for conservation. This review aims to critically assess scientific literature related to commonly adopted analytical techniques for the analysis of metal soaps in oil paintings. A comparison of different analytical methods is provided, highlighting advantages associated with each, as well as limitations identified through the analysis of reference materials and applications to the analysis of samples from historical paintings. 相似文献
107.
108.
We analyze statistical scaling of structural attributes of two millimeter scale rock samples, Estaillades limestone and Bentheimer sandstone. The two samples have different connected porosities and pore structures. The pore-space geometry of each sample is reconstructed via X-ray micro-tomography at micrometer resolution. Directional distributions of porosity and specific surface area (SSA), which are key Minkowski functionals (geometric observables) employed to describe the pore-space structure, are calculated from the images, and scaling of associated order- $q$ sample structure functions of absolute incremental values is analyzed. Increments of porosity and SSA tend to be statistically dependent and persistent (tendency for large and small values to alternate mildly) in space. Structure functions scale as powers $\xi (q)$ of directional separation distance or lag, $s$ , over an intermediate range of $s$ , displaying breakdown in power law scaling at large and small lags. Powers $\xi \!\!\left( q \right) $ of porosity and SSA inferred from moment and extended self-similarity (ESS) analyses of limestone and sandstone data tend to be quasi-linear and nonlinear (concave) in $q$ , respectively. We observe an anisotropic behavior for $\xi (q)$ , which appears to be mild for the porosity of the sandstone sample while it is marked for both porosity and SSA of the limestone rock sample. The documented nonlinear scaling behavior is amenable to analysis by viewing the variables as samples from sub-Gaussian random fields subordinated to truncated fractional Brownian motion or fractional Gaussian noise. 相似文献
109.
Maxia A Frau MA Foddis C Lancioni MC Kasture V Kasture S 《Natural product research》2012,26(5):438-445
In the traditional Sardinian system of medicine, Rubia peregrina L. (Rubiaceae) is reported as an aphrodisiac herb. Since the aphrodisiacs may also have antioxidant and dopaminergic activities, the aim of this study was to study the effect of ethanolic extract of aerial parts of R. peregrina for the scavenging of free DPPH radicals and the inhibition of haloperidol-induced catalepsy in mice and reserpine-induced orofacial dyskinesia in rats. The extract exhibited significant antioxidant activity in a free radical DPPH assay with IC(50)?=?55.6?μg?mL(-1), which was very close to IC(50) of ascorbic acid. The extract of R. peregrina (100 and 200?mg?kg(-1) intraperitoneally, i.p.) significantly inhibited haloperidol (1?mg?kg(-1) i.p.) - induced catalepsy in mice (p?0.01). In rats, the extract (200?mg?kg(-1) i.p.) significantly (p?0.01) inhibited the orofacial dyskinesia induced by intraperitoneal administration of reserpine (1?mg?kg(-1) on days 1, 3 and 5). This study demonstrates that R. peregrina has antioxidant activity and improves the dopaminergic function. Results therefore justify the development of further experiments to investigate the psychopharmacological profile of R. peregrina. 相似文献
110.
C Chirivì G Fontana D Monti G Ottolina S Riva B Danieli 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(33):10355-10361
Laccase-catalysed oxidation of ergot alkaloids in the absence of chemical mediators allowed the unexpected isolation of the mono-hydroxylated derivatives of compounds 2-7. Structure determination by NMR techniques clearly indicated that hydroxylation took place at the C-4 benzylic position. Quite notably, the proposed protocol allowed, for the first time, functionalisation at the C-4 position of the ergoline skeleton. Depending on the absence or on the presence of a C-10 α-methoxy substituent, hydroxylation was either stereoselective (furnishing C-4α OH derivatives) or gave rise to a C-4α/C-4β OH mixture in a 2:1 ratio, respectively. 相似文献