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排序方式: 共有190条查询结果,搜索用时 15 毫秒
11.
Son Tung Ngo Trung Hai Nguyen Nguyen Thanh Tung Pham Cam Nam Khanh B. Vu Van V. Vu 《Journal of computational chemistry》2020,41(7):611-618
Determination of the ligand-binding affinity is an extremely interesting problem. Normally, the free energy perturbation (FEP) method provides an appropriate result. However, it is of great interest to improve the accuracy and precision of this method. In this context, temperature replica exchange molecular dynamics implementation of the FEP computational approach, which we call replica exchange free energy perturbation (REP) was proposed. In particular, during REP simulations, the system can easily escape from being trapped in local minima by exchanging configurations with high temperatures, resulting in significant improvement in the accuracy and precision of protein–ligand binding affinity calculations. The distribution of the decoupling free energy was enlarged, and its mean values were decreased. This results in changes in the magnitude of the calculated binding free energies as well as in alteration in the binding mechanism. Moreover, the REP correlation coefficient with respect to experiment ( RREP = 0.85 ± 0.15 ) is significantly boosted in comparison with the FEP one ( RFEP = 0.64 ± 0.30 ). Furthermore, the root-mean-square error (RMSE) of REP is also smaller than FEP, RMSEREP = 4.28 ± 0.69 versus RMSEFEP = 5.80 ± 1.11 kcal/mol, respectively. © 2019 Wiley Periodicals, Inc. 相似文献
12.
Angela Giorgia Potortì Alessia Tropea Vito Pellizzeri Asma Belfita Giacomo Dugo 《Natural product research》2020,34(1):167-171
AbstractSpices and aromatic herbs can be contaminated with mycotoxins, since of their preharvest, postharvest, and storage conditions. In this study, 112 samples of different spices and aromatic herbs were evaluated for their mycotoxins content by HPLC-MS/MS in order to highlight their possible risk linked with human use. The results showed that mycotoxins were occasionally detected only in samples of coriander, laurel, mint, rosemary, and verbena. In both geographical origins a different contamination was detected. Among the investigated mycotoxins, AFB2, AFG1, AFG2, T2 and HT2 were detected, whereas none of the samples contained AFB1 and FB1. The co-occurrence of two toxins were observed for some samples of rosemary and verbena. This study indicates that it is essential minimize the toxins in agriculture, industry, and food-product manufacturing for the consumer health protection. 相似文献
13.
High-precision sub-pixel interpolation in particle image velocimetry image processing 总被引:4,自引:0,他引:4
The task of image interpolation and re-sampling for particle image velocimetry (PIV) is investigated, which is used for window shifting with sub-pixel accuracy and image or window deformation. A new interpolation scheme based on a Gaussian filter is introduced and compared with commonly used and widely accepted interpolation techniques in terms of the achievable root mean square deviation of the displacement estimates. 相似文献
14.
This study deals with the Reynolds‐averaged Navier–Stokes simulation of evaporation in a turbulent gas–liquid flow in a three‐dimensional duct, focussing on the results obtained by a four‐equation turbulence model within the framework of the Euler/Euler approach for multiphase flow calculations: in addition to the two‐equation k?ε model describing the turbulence of the continuous (C) phase, the computational model employs transport equations for the turbulence kinetic energy of the disperse (D) phase and for the velocity covariance q=〈{u}D{u}C〉D. In the present study, the evaporation model according to Abramzon and Sirignano (Int. J. Heat Mass Transfer 1989; 32 :1605–1618) has been extended by introducing an additional transport equation for a newly defined quantity ā, defined as the phase‐interface surface fraction. This allows the change in the drop diameter to be quantified in terms of a probability density function. The source term in the equation describing the dynamics of the volumetric fraction of the dispersed phase αD is related to the evaporation time scale τΓ. The performance of the new model is evaluated by performing a comparative analysis of the results obtained by simulating a polydispersed spray in a three‐dimensional duct configuration with the results of the Euler/Lagrange calculations performed in parallel. Prior to these calculations, some selected (solid) particle‐laden flow configurations were computationally examined with respect to the validation of the background, four‐equation, eddy‐viscosity‐based turbulence model. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
15.
Simultaneous velocity and concentration measurements have been performed in a gas-turbine combustor model. Particle image velocimetry (PIV) was used to acquire planar velocity information and to identify coherent flow structures. The Mie scattering technique, based on a slightly modified experimental setup, was used for concentration measurements in this mixing flow. The degree of mixing was assessed by examining local concentration measurements while inhomogeneously seeding the primary and secondary stream of the mixing layer. Connections between flow field and concentration distribution were highlighted using the proper orthogonal decomposition algorithm (POD). Uncertainties and systematic errors for the PIV measurements due to the suboptimal seeding are discussed using a comparison with a second test series at optimal seeding conditions. Results are presented for several flow parameters and at various lateral planes. 相似文献
16.
Ji-Yao Li Biaoxin Chai Weizhen Zhang Xiaobin Wu Chao Zhang Danielle Fritze Zefeng Xia Cam Patterson Michael W Mulholland 《BMC neuroscience》2011,12(1):1-10
Background
Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contraction via the Raf/extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK) pathway.Results
Rats were exposed to SHS for up to 8 weeks. The cerebral artery vasoconstriction was recorded by a sensitive myograph. The mRNA and protein expressions for endothelin receptors in cerebral arteries were studied by real-time PCR and Western blot. Compared to fresh air exposed rats, cerebral arteries from SHS rats exhibited stronger contractile responses (P < 0.05) mediated by endothelin type A (ETA) receptors. The expressions of mRNA and protein for ETA receptors in the cerebral arteries from SHS rats were higher (P < 0.05) than that in control. SHS did not affect endothelin type B (ETB) receptor-mediated contractions, mRNA or protein levels. The results suggest that SHS upregulates ETA, but not ETB receptors in vivo. After SHS exposure, the mRNA levels of Raf-1 and ERK1/2, the protein expression of phosphorylated (p)-Raf-1 and p-ERK1/2 were increased (P < 0.05). Raf-1 inhibitor, GW5074 suppressed the enhanced ETA receptor-mediated contraction, mRNA and protein levels induced by SHS. In addition, GW5074 inhibited the SHS-caused increased mRNA and phosphorylated protein levels of Raf-1 and ERK1/2, suggesting that SHS induces activation of the Raf/ERK/MAPK pathway.Conclusions
SHS upregulates cerebrovascular ETA receptors via the Raf/ERK/MAPK pathway, which provides novel understanding of mechanisms involved in SHS-associated stroke. 相似文献17.
The design and performance of millimeter-wave microstrip/suspended-stripline end-coupled bandpass filters are presented. Filters in Ka-band (26.5 to 40 GHz) and W-band (75 to 110 GHz) using suspended-stripline and microstrip have been designed. Good agreement between the experimental results and those predicted theoretically was observed. Measured passband insertion losses of less than 1 and 0.5 dB have been achieved in W- and Ka-band, respectively. An extremely wideband waveguide-to-microstrip transition with an insertion loss of 0.25 dB over the full W-band is also presented. 相似文献
18.
The transformation of temporal, one-point correlation functions into longitudinal spatial and spatio-temporal correlation functions in turbulent flows using a simple statistical convection model is introduced. To illustrate and verify the procedure, experimental data (one-point and two-point) have been obtained with a laser Doppler system from a turbulent, round, free-air jet. 相似文献
19.
20.
Comparison of CCD,CMOS and intensified cameras 总被引:2,自引:0,他引:2
The properties of digital cameras are often important to obtain accurate results with image based measurement techniques.
Unfortunately, a detailed comparison of the sensor specifications and performance is not accessible as this information is
normally not provided by the manufacturers and no generally accepted comparison standard exists. Therefore, a detailed quantitative
comparison was performed to evaluate and assess the characteristics of state-of-the-art CCD, CMOS and intensified CMOS sensors.
These results may be of assistance when selecting the appropriate sensor for a desired application. 相似文献