Direct measurement of the W Boson width in ppover collisions at square roots = 1.96 TeV

A direct measurement of the total decay width of the W boson Gamma(W) is presented using 350 pb(-1) of data from pp[over ] collisions at square root s = 1.96 TeV collected with the CDF II detector at the Fermilab Tevatron. The width is determined by normalizing predicted signal and background distributions to 230 185 W candidates decaying to enu and micronu in the transverse-mass region 50相似文献   

Search for large extra dimensions in final states containing one photon or jet and large missing transverse energy produced in pp collisions at square root[s]=1.96 TeV

We present the results of searches for large extra dimensions in samples of events with large missing transverse energy E_{T} and either a photon or a jet produced in pp[over ] collisions at sqrt[s]=1.96 TeV collected with the Collider Detector at Fermilab II. For gamma+E_{T} and jet+E_{T} candidate samples corresponding to 2.0 and 1.1 fb;{-1} of integrated luminosity, respectively, we observe good agreement with standard model expectations and obtain a combined lower limit on the fundamental parameter of the large extra dimensions model M_{D} as a function of the number of extra dimensions in the model.     

Measurement of Lifetime and Decay-Width Difference in B_{s};{0}-->J/psivarphi Decays

We measure the mean lifetime tau=2/(Gamma_{L}+Gamma_{H}) and the decay-width difference DeltaGamma=Gamma_{L}-Gamma_{H} of the light and heavy mass eigenstates of the B_{s}{0} meson, B_{sL}{0} and B_{sH}{0}, in B_{s}{0}-->J/psivarphi decays using 1.7 fb;{-1} of data collected with the CDF II detector at the Fermilab Tevatron pp[over ] collider. Assuming CP conservation, a good approximation for the B_{s}{0} system in the standard model, we obtain DeltaGamma=0.076_{-0.063}{+0.059}(stat)+/-0.006(syst) ps{-1} and tau=1.52+/-0.04(stat)+/-0.02(syst) ps, the most precise measurements to date. Our constraints on the weak phase and DeltaGamma are consistent with CP conservation.     

Regiospecificity of nucleotide–amino acid mating vs. water dynamics: a key to protein–nucleic acid assemblies: structure of unidecahydrated inosine-5′-monophosphate and L–glutamic acid (2C10H13N4O8P·C5H11NO4·11H2O) cocrystal at atomic resolution

The crystal structure of a unidecahydrated cocomplex between two Inosine-5-monophosphates (IMP) and one L-glutamic acid has been determined by X-ray crystallographic methods. The crystal belongs to the monoclinic space group P2₁ with cell dimensions a = 8.650(1), b = 21.900(1), c = 12.370(1) Å, and = 110.4°(9). This structure reveals extensive hydrogen bonding of glutamic acid to the nucleotide through direct and water-mediated interactions. The phosphate oxygens (O3B and O1B) seem to prefer nonspecific interaction with the functional sites of glutamic acid (OE2 ······O1B = 1.78 Å, NA······O3B = 2.73 Å, OH······O3B = 3.06 Å), whereas the bases prefer specific (O······N3B = 2.88 Å) binding. A solvent mediated N7A···W5···N7B hydrogen bond used for stabilization of the stacked purine bases has been observed as in other amino acid–nucleotide cocrystals. Glutamic acid occupies the same hydrophilic region in the nucleotide cocrystal as was found in glutamine–inosine monophosphate (Gln–IMP) and in serine–inosine monophosphate (Ser–IMP) complexes through substantial replacement of free and bound water molecules. This points to the dynamic hydrogen bonding nature of the water molecules and their stereochemical cooperation for the placement of amino acid through the polycoordination within the crystal.     

Solid dispersion systems engineered from hydroxypropyl‐β‐cyclodextrin and water‐soluble polymers for enhanced oral bioavailability of nimodipine

Nimodipine (NMD) is a calcium channel blocker that is used in the treatment of cerebrovascular disorders, such as stroke indicated for biological rhythm and neurological disorders. According to biopharmaceutical classification, NMD is categorized as a class ΙΙ drug, meaning it has a poor solubility profile. The objective of this experiment is to prepare multicomponent systems to enhance the solubility, dissolution, and bioavailability of NMD. Inclusion complex and solvent evaporation techniques have been exploited to overcome this challenge. in vitro dissolution studies and solubility, the profile was performed in three pH media (pH 7.5, 1.2, and 6.8). The drug release at (Q_60min) for SD‐PVP3 was 33‐fold higher than pure NMD in double‐distilled water. The solubility of SD PVP3 was about 30 times higher than plain NMD in double‐distilled water. A pharmacokinetic study in rats indicated that the AUC_0‐720 value of the inclusion complex (NMD‐KD) was 1.63‐fold higher than pure NMD. At the same time, the solid dispersion (NMD‐SD PVP3) was 3.94‐fold higher than that of plain NMD, indicating a significant increase in the bioavailability of NMD. The combination of the inclusion complex and solvent evaporation method led to the formation of new solid dispersions (SD PLX and SD PVP), which significantly increased the solubility, dissolution, and the oral bioavailability of NMD.     

Search for new dielectron resonances and Randall-Sundrum gravitons at the collider detector at Fermilab

A search for new dielectron-mass resonances using data recorded by the CDF II detector and corresponding to an integrated luminosity of 5.7 fb(-1) is presented. No significant excess over the expected standard model prediction is observed. In this data set, an event with the highest dielectron mass ever observed (960 GeV/c(2)) was recorded. The results are interpreted in the Randall-Sundrum (RS) model. Combined with the 5.4 fb(-1) diphoton analysis, the RS-graviton lower-mass limit for the coupling k/Mˉ(Pl)=0.1 is 1058 GeV/c(2), making it the strongest limit to date.     

Measurement of the forward-backward asymmetry in the B→K*μ(+)μ(-) decay and first observation of the B(s)0→ϕμ(+)μ(-) decay

We reconstruct the rare decays B(+)→K(+)μ(+0μ(-0, B90)→K*(892)(0)μ(+)μ(-), and B(s)(0)→?(1020)μ(+)μ(-) in a data sample corresponding to 4.4 fb(-1) collected in pp collisions at √[s]=1.96 TeV by the CDF II detector at the Tevatron Collider. Using 121±16 B(+)→K(+)μ(+)μ(-) and 101±12 B(0)→K(*0)μ(+)μ(-) decays we report the branching ratios. In addition, we report the differential branching ratio and the muon forward-backward asymmetry in the B(+) and B(0) decay modes, and the K(*0) longitudinal polarization fraction in the B(0) decay mode with respect to the squared dimuon mass. These are consistent with the predictions, and most recent determinations from other experiments and of comparable accuracy. We also report the first observation of the B(s)(0)→?μ(+)μ(-) decay and measure its branching ratio BR(B(s)(0)→?μ(+)μ(-))=[1.44±0.33±0.46]×10(-6) using 27±6 signal events. This is currently the most rare B(s)(0) decay observed.     

Measurement of the B(s)0 lifetime in fully and partially reconstructed B(s)0→D(s)(-)(ϕπ(-))X decays in p¯p collisions at √s=1.96 TeV

We present a measurement of the B(s)(0) lifetime in fully and partially reconstructed B(s)(0)→D(s)(-)(?π(-))X decays in 1.3 fb(-1) collected in pp ˉ collisions at √s=1.96 TeV by the CDF II detector at the Fermilab Tevatron. We measure τ(B(s)(0))=1.518±0.041(stat)±0.027(syst) ps. The ratio of this result and the world average B(0) lifetime yields τ(B(s)(0))/τ(B(0))=0.99±0.03, which is in agreement with recent theoretical predictions.     

Modeling of Swelling Behaviors of Acrylamide-Based Polymeric Hydrogels by Intelligent System

Hydrogels based on acrylamide (AAm) were synthesized by free radical polymerization in an aqueous solution using N,N’-methylenebisacrylamide (MBAAm) as crosslinker. To obtain anionic hydrogels, 2-acrylamido-2-methylpropanesulfonic acid sodium salt (AMPS) and acrylic acid (AAc) were used as comonomers. The swelling behaviors of all hydrogel systems were modeled using an artificial neural network (ANN) and compared with a multivariable least squares regression (MLSR) model and phenomenal model. The predictions from the ANN model, which associated input parameters, including the amounts of crosslinker (MBA) and comonomer, and swelling values with time, produce results that show excellent correlation with experimental data. The parameters of swelling kinetics and water diffusion mechanisms of the hydrogels were calculated using the obtained experimental data. Model analysis indicated that the ANN models could accurately describe complex swelling behaviors of highly swellable hydrogels.