Surface Coating Rescues Proteins from Magnetite Nanoparticle Induced Damage

The presence of magnetic nanoparticles (NPs) in physiological systems induces toxicity through its effects on mitochondrial function and reactive oxygen species (ROS) imbalance. Magnetic NP induced cytotoxicity has been elaborately evaluated for impending threats, however, a detailed investigation is lacking. It is shown that the interaction of Fe₃O₄ NPs with cytochrome c can lead to different events based on the NPs to protein ratio, the solution conditions, and the type of surface protection. At low NPs concentration, rapid binding and subsequent electron transfer are the preferred events while at higher concentration slow oxidative modification of the protein is initiated. The slow event of protein modification yields conformational disorientation, loss of stability, and formation of amyloid‐like structures with cytochrome c. The possibility that the NP induced oxidative stress and age can work in concert to compromise different aspects of cellular quality control processes is discussed. Suitable surface modifications of the NPs inhibit their direct binding to the protein molecules and minimize NP induced toxicity.     

A stochastic manpower planning model under varying class sizes

Solution related to different types of manpower planning problems arising in different industries and organizations are very much helpful for proper planning and implementation of different objectives. Previously those type of problems are mostly solved under the deterministic set up. Gradually several scientists have developed different types of stochastic models appropriate for solving such types of problems. The present study is an attempt to develop a stochastic manpower planning model under the set up where the classes are of varying sizes and promotion occurs only on the basis of seniority. The work of second author was supported by a research fellowship from Council of Scientific and Industrial Research (Sanction No. 9/28(611)/2003-EMR-I), India.     

Effect of energy distribution of interface states on the electrical characteristics of semiconductor heterojunction diode

An energy distribution of interface states has been considered to study the electrical characteristics of an anisotype semiconductor heterojunction. Various electrical quantities such as the surface potential, current, conductance and ideality factor of the device have been studied. The current-voltage and conductance-voltage characteristics are found largely sensitive to the parameters controlling the distribution profile of interface states. A new expression for the ideality factor of the device has been derived, which predicts appreciable voltage dependence due to the distributive nature of the interface states. It has been found that the experimental I-V data of p-InP/n-CdS heterojunction reported by earlier workers can be satisfactorily explained with the help of the present model if the effect of shunt resistance of the device is included in the evaluation scheme.     

Optical Generation of mm-Wave Signal Through Optoelectronic Phase-Locked Loop

In this paper, we propose a scheme for the generation of low phase noise tunable mm-wave signal by beating two lightwaves in a photodiode. These two lightwaves are made phase coherent by an optoelectronic phase locked loop.Calculated mm-wave power at a frequency of 60 GHz is found to be -4 dBm.     

Synthesis, crystal structure determination, spectroscopic and electrochemical studies of trans-[Ru(PPh3)2(bbpH2)Cl]Cl·CHCl3·H20 (bbpH2=2,6-bis(benzimidazolyl) pyridine) – an infinite double columnar supramolecule in the solid state

The synthesis, crystal structure, redox and spectroscopic properties of trans-[Ru(bbpH₂)(PPh₃)₂Cl]Cl are reported. In the crystalline solvate trans-[Ru(bbpH₂)(PPh₃)₂cCl]Cl CHCl₃ H₂O, the molecular components are connected by strong intermolecular hydrogen bonding to form an infinite double column.     

Investigation of the boundary value problem corresponding to a generalized Skyrme lagrangian

A detailed numerical analysis of the boundary value problem resulting from the most general Skyrme type lagrangian containing up to quartic terms in field gradients is presented. The additional parameters in the lagrangian can be related to pion-pion scattering lengths. It is found that solutions to the boundary value problem does not exist for all values of the parameters and in particular, for the values predicted from pion-pion scattering data. Physical quantities of the nucleon are calculated for the highest possible values of the parameters admitting a solution and are compared with the corresponding values for the Skyrme model and experimental values.     

An improved theoretical model of the dc characteristics of metal-semiconductor field effect transistors

Received: 15 August 1997/Accepted: 13 November 1997