Nonlinear Dynamics - This paper introduces a procedure in the field of computational contact mechanics to analyze contact dynamics of beams undergoing large overall motion with large deformations... 相似文献
We consider hypothesis testing for high-dimensional covariance structures in which the covariance matrix is a (i) scaled identity matrix, (ii) diagonal matrix, or (iii) intraclass covariance matrix. Our purpose is to systematically establish a nonparametric approach for testing the high-dimensional covariance structures (i)–(iii). We produce a new common test statistic for each covariance structure and show that the test statistic is an unbiased estimator of its corresponding test parameter. We prove that the test statistic establishes the asymptotic normality. We propose a new test procedure for (i)–(iii) and evaluate its asymptotic size and power theoretically when both the dimension and sample size increase. We investigate the performance of the proposed test procedure in simulations. As an application of testing the covariance structures, we give a test procedure to identify an eigenvector. Finally, we demonstrate the proposed test procedure by using a microarray data set.
We consider the non-relativistic Hartree model in the gravitational case, i.e. with attractive Coulomb–Newton interaction.
For a given mass M > 0, we construct stationary states with non-zero temperature T by minimizing the corresponding free energy functional. It is proved that minimizers exist if and only if the temperature
of the system is below a certain threshold T* > 0 (possibly infinite), which itself depends on the specific choice of the entropy functional. We also investigate whether
the corresponding minimizers are mixed or pure quantum states and characterize a critical temperature Tc ? (0, T*){T_c \in (0, T*)} above which mixed states appear. 相似文献
The kinetics of a nitroxide radical in the renal parenchyma and pelvis in rats were investigated by employing an in vivo EPR imaging system equipped with a surface-coil-type resonator (SCR). The exposed kidney of a living rat was inserted into the single-turn coil of the SCR, with the renal major axis aligned with the direction of alternative magnetic field (B(1)). After the injection of nitroxide radical via the tail vein, EPR measurements were repeated. From the temporal EPR images of the kidney on the 2-D projection to the plane which is perpendicular to the direction of B(1,) the decay rate of nitroxide radical in the renal parenchyma and pelvis was estimated. The parenchymal decay rate was found to be significantly shorter than that for the pelvis. 相似文献
Magnetic resonance angiography (MRA) is an imaging method to examine blood vessels based on the magnetic resonance imaging (MRI) technique. For this purpose, blood pool contrast agents have been developed to selectively increase the signal intensity of the intravascular lumen for improvement of the contrast-to-noise ratio in MR images. Here, we describe the design and the syntheses of six novel sulfonated contrast agents (KMR-Sulfo1 - 6), their chemical properties and their in vivo applications. In this study, we investigated the lipophilicity and the hydrophilicity of a gadolinium complex using a convenient two-step synthesis route, with the goal of prolonging the plasma half-life by binding mainly to human serum albumin. We confirmed that KMR-Sulfo5 fulfilled the requirements as a blood pool contrast agent: it showed a sufficient relaxivity r(1) of 5.9 mM(-1) s(-1), a long plasma half-life of 25.7 min and complete elimination from the body within 12 h after the administration. 相似文献
Herein, we describe the first asymmetric total synthesis and determination of the relative and absolute stereochemistry of naturally occurring 16‐hydroxy‐16,22‐dihydroapparicine. The key steps include 1) a novel phosphinimine‐mediated cascade reaction to construct the unique 1‐azabicyclo[4.2.2]decane core, including a pseudo‐aminal‐type moiety; 2) a highly stereospecific 1,2‐addition of 2‐acylindole or a methylketone through a Felkin–Anh transition state for the construction of a tetrasubstituted carbon center; and 3) an intramolecular chirality‐transferring Michael reaction of the ketoester, with neighboring‐group participation, to introduce a chiral center at C15 in the target molecule. In addition, we evaluated the antimalarial activity of synthetic (+)‐(15S,16R)‐16‐hydroxy‐16,22‐dihydroapparicine and its intermediate against chloroquine‐resistant Plasmodium falciparum (K1 strain) parasites. 相似文献
DNA adductome analysis using liquid chromatography–tandem mass spectrometry is a promising tool to exhaustively search DNA modifications. Given that the molecular weight of chemical-specific adducts is determined by the total molecular weights of the active form and nucleotide bases, we developed a new method of comprehensive analysis for chemical-specific DNA adducts based on the principle of adductome analysis. The actual analytical mass range was 50 mass units up or down from the average molecular weight of the four DNA bases plus the molecular weight of the expected active form of the chemical. Using lucidin-3-O-primeveroside (LuP), lucidin-modified bases formed by its active form were exhaustively searched using this new method. Various DNA adducts, including Luc-N2-dG and Luc-N6-dA, were identified in the kidneys of rats given LuP. Together with measurement of 8-hydroxydeoxyguanosine (8-OHdG) levels, the combined application of this new method with a reporter gene mutation assay was performed to clarify renal carcinogenesis induced by madder color (MC) that includes LuP and alizarin (Alz) as constituent agents. A DNA adductome map derived from MC-treated rats was almost identical to that of LuP-treated rats, but not Alz-treated rats. Although 8-OHdG levels were elevated in MC- and Alz-treated rats, significant increases in gpt and Spi? mutant frequencies were observed only in MC- and LuP-treated rats. In addition, the spectrum of gpt mutants in MC-treated rats showed almost the same pattern as those in LuP-treated rats. The overall data suggest that LuP may be responsible for MC-induced carcinogenicity and that the proposed methodology is appropriate for exploring and understanding mechanisms of chemical carcinogenesis.
Figure
DNA adductome map of kidneys from F344 gpt delta rats in the control and LuP-treated groups. The peaks detected in control and LuP-treated rats are represented as black and blue spots, respectively 相似文献