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21.
Effect of sterilization on non-woven polyethylene terephthalate fiber structures for vascular grafts
Dimitrievska S Petit A Doillon CJ Epure L Ajji A Yahia L Bureau MN 《Macromolecular bioscience》2011,11(1):13-21
Non-woven polyethylene terephthalate (PET) fibers produced via melt blowing and compounded into a 6 mm diameter 3D tubular scaffold were developed with artery matching mechanical properties. This work compares the effects of ethylene oxide (EtO) and low temperature plasma (LTP) sterilization on PET surface chemistry and biocompatibility. As seen through X-ray photoelectron spectroscopy (XPS) analysis, LTP sterilization led to an increase in overall oxygen content and the creation of new hydroxyl groups. EtO sterilization induced alkylation of the PET polymer. The in vitro cytotoxicity showed similar fibroblastic viability on LTP- and EtO-treated PET fibers. However, TNF-α release levels, indicative of macrophage activation, were significantly higher when macrophages were incubated on EtO-treated PET fibers. Subcutaneous mice implantation revealed an inflammatory response with foreign body reaction to PET grafts independent of the sterilization procedure. 相似文献
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Hanane El Hajaji Nadya Lachkar Katim Alaoui Yahya Cherrah Abdellah Farah Abdesslam Ennabili Brahim El Bali Mohammed Lachkar 《Arabian Journal of Chemistry》2011,4(3):321-324
We evaluated the in vitro antioxidant property and phytochemical constituents of the crude ethyl acetate and methanol extract of the three genders of carob tree barks (spontaneous male, spontaneous female, and grafted female). The scavenging activity on DPPH (1,1-diphenyl-2-picrylhydrazyl) was determined, as well as the phenolic contents (Folin–Ciocalteu method) of both the extracts. The highest antioxidant activity and the higher amounts of total phenols were shown in methanol crude bark extract for the three genders. Variety significantly affected the phenol content and the antioxidant activity, with the spontaneous male variety globally showed a higher polyphenol concentration and antioxidant activity than the grafted female and spontaneous female. 相似文献
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Abdellah Bnouhachem Muhammad Aslam Noor 《Journal of Mathematical Analysis and Applications》2006,324(2):1195-1212
In this paper, we suggest and analyze a new inexact proximal point method for solving general variational inequalities, which can be considered as an implicit predictor-corrector method. An easily measurable error term is proposed with further relaxed error bound and an optimal step length is obtained by maximizing the profit-function and is dependent on the previous points. Our results include several known and new techniques for solving variational inequalities and related optimization problems. Results obtained in this paper can be viewed as an important improvement and refinement of the previously known results. Preliminary numerical experiments are included to illustrate the advantage and efficiency of the proposed method. 相似文献
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Arrahli Abdellah Kherbeche Abdelhak Bianchi Daniel 《Research on Chemical Intermediates》2019,45(3):1421-1436
Research on Chemical Intermediates - FTIR spectroscopy and volumetric measurements are used to study the adsorption of CO (mainly 1% CO/He) in the temperature range 300–713 K on a... 相似文献
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Adnane Aouidate Adib Ghaleb Mounir Ghamali Samir Chtita Abdellah Ousaa M’barek Choukrad Abdelouahid Sbai Mohammed Bouachrine Tahar Lakhlifi 《Chemical Papers》2018,72(11):2833-2847
Ca2+/calmodulin-dependent protein kinase II (CAMKIIδ) belongs to the serine/threonine kinase family, which is involved in a broad range of cellular events in cell survival and proliferation as well as a number of other signal transduction pathways. Thus, it is regarded a promising target for treatment of cancers. In the present paper, a three-dimensional quantitative structure–activity relationship and molecular docking were applied to investigate a series of new CAMKIIδ inhibitors of pyrazolopyrimidine derivatives. The determination coefficient (R2) and leave-one-out cross-validation coefficient (Q2) of CoMSIA model are 0.676 and 0.956, respectively. The predictive ability of this model was evaluated by the external validation using a test set of eight compounds with a predicted determination coefficient \(R^{ 2}_{\text{test}}\) of 0.80, besides the mean absolute error of the test set was 0.328 log units. Docking results are in concordance with CoMSIA contour maps, gave the information for interactive mode exploration. Based on those satisfactory results, newly designed molecules were predicted with highly potent CAMKIIδ inhibitory activity, additionally, they have showed promising results in the preliminary in silico ADMET evaluations. This study could expand our understanding of pyrazolopyrimidine derivatives as inhibitors of CAMKIIδ and would be of great help in lead optimization for early drug discovery of highly potent CAMKIIδ inhibitors. 相似文献
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When defatted jojoba meal is used as animal food, it causes food-intake reduction and growth retardation. Detoxification procedures by chemical, microbiological, and solvent extraction methods are reported by several authors. Here we report a successful detoxification of jojoba meal using enzymes. We establish reaction conditions that yield new meal which has the same nutritional qualities in proteins as the original meal. The enzymatic reaction gives rise to one major compound to which the structure of an amide is assigned on the basis of IR, 1H and 13C NMR spectra. The effect of the resulting jojoba meal on the food intake in rats is checked. In contrast, the detoxified meal containing the amide derivatives shows no toxicological activity since rats receiving oral administration of the obtained meal show normal growth. Thus, it is expected that this meal could be used as an animal feed ingredient. 相似文献