4-(N-取代苯基)氨基喹唑啉类化合物的合成及抗磷酸化活性研究

以4-氯喹唑啉为起始原料, 经环化、氯化、取代三步反应, 合成了8个新的4-取代苯基氨基喹唑啉类化合物. 采用¹H NMR, ¹³C NMR, MS, IR及元素分析对目标化合物的结构进行了表征. 生物活性测试表明, 化合物1f在1 μmol• L^－1 浓度下对PC3细胞增殖抑制活性达到88.6%, 进一步研究表明该化合物具有较高的抑制细胞外信号调节激酶(ERK)磷酸化的活性.     

基于多金属氧簇的手性超分子液晶

以手性诱导为切入点,采用含胆固醇基团的季铵盐表面活性剂静电包覆缺位的Keggin结构多金属氧簇K7PW11O39·12H2O,得到了手性介晶阳离子修饰的多金属氧簇杂化超分子复合物。圆二色谱对该复合物光学活性的表征说明外围的手性表面活性剂可以通过静电相互作用诱导复合物显示出手性。利用差示扫描量热曲线法、偏光显微镜观察和变温X射线衍射详细研究了该复合物的热性质和相行为,结果表明该复合物在较宽的温度范围内具有热致液晶性质,是一种典型的手性近晶A相离子液晶材料。     

高等院校化学实验室废弃物问题的思考

介绍了国内化学废弃物处置方面的相关法规和管理办法,并以美国休斯顿大学为例,介绍了美国高校实验室废弃物处置机制,包括法规、机构、管理办法、责任等。以2010至2011年间美国化学会Journal of Chemical Education期刊中涉及废弃物处置的四个教学实验,阐述了"3R"(循环、减量、再利用)绿色化学原则。最后以北京大学为例,介绍我国高校化学实验室对废弃物处理的做法。     

搭建紫外可见光谱仪并用于科普互动

搭建科普型可互动紫外可见光谱仪,将光谱仪的内部构造、光路和光学部件的作用展示出来,弥补了目前商业化仪器"黑盒子"的弊端。将搭建好的光谱仪与简易物理学光路和实际有色饮料样品有机结合,设计环环相扣的科普互动,展示出颜色、浓度和光之间的内在联系,可向不同人群科普化学在生活中的重要性以及分析仪器作为化学学科"放大镜"的必要性。     

Sr2CeO4∶Eu3+柠檬酸-凝胶法的合成及发光性质研究

柠檬酸-凝胶方法促使多离子在分子水平上混合，与固相烧结方法相比，能够降低烧结温度和烧结时间。利用这种方法在1000℃下很短的时间得到单相化合物Sr₂CeO₄。Sr₂CeO₄是一种发出很强蓝光的基质发光材料。为寻找新的发光体，我们将稀土离子Eu³⁺掺杂在其中，从荧光光谱上可以看出存在从基质向稀土离子的能量转移。Sr₂CeO₄∶Eu³⁺的发光颜色可调谐，当Eu³⁺离子浓度较小(< 0.5mol%)时，体系发出很强的白光;当Eu³⁺离子浓度较大(>10mol%)时，体系发出很强的红光，并且猝灭浓度高。     

^31P NMR Studies on the Ligand Dissociation of Trinuclear Molybde-num Cluster Compounds

A series of carboxylate-substituted trinudear molybdenum dus-ter compounds formulated as Mo3S4(DTP)3(RCO2)(L), where RffiH, CH3, C2H5, CH2Cl, CCl3, R^1C6H4(R^1 is the group on the benzene ring of aromatic carboxylate ), L=pyridine,CH3CN, DMF, have been synthesized by the ligand substitu-tion reaction. The dissociation of the loosely-coordinated ligand L from the cluster core was studied by ^31p NMR. The dissocia-tion process of L is related to the solvent, temperature, and acidity of carboxylate groups, so as to affect the solution struc-ture and reactive properties of the duster. The long-distance in-teraction between ligands RCO2 and L is transported by Mo3S4 core.     

Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety

Chiral α-aminophosphonates were synthesized using （R） or （S）-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.     

Adsorption Study of Methane on Activated Meso-carbon Microbeads by Density Functional Theory

A combined method of density functional theory (DFT) and statistics integral equation (SIE) for the determination of the pore size distribution (PSD) is developed based on the experimental adsorption data of nitrogen on activated mesocarbon microbead (AMCMB) at 77K. The pores of AMCMB are described as slit-shaped with PSD.Based on the PSD, methane adsorption and phase behavior are studied by the DFT method. Both nitrogen and methane molecules are modeled as Lennard-Jones spherical molecules, and the well-known Steele‘s 10-4-3 potential is used to represent the interaction between the fluid molecule and the solid wall. In order to test the combined method and the PSD model, the Intelligent Gravimetric Analyzer (IGA-003) was used to measure the adsorption of methane on the AMCMB. The DFT results are in good agreement with the experimental data. Based on these facts,we predict the adsorption amount of methane, which can reach 32.3ω at 299K and 4 MPa. The results indicate that the AMCMBs are a good candidate for adsorptive storage of methane and natural gas. In addition, the capillary condensation and hysteresis phenomenon of methane are also observed at 74.05K.     

肟类衍生物的合成与农药生物活性的研究进展

肟类化合物具有优良的杀虫、杀菌及除草活性, 不少品种还具有低毒、低残留等优点. 目前该类化合物的分子设计和合成及生物活性研究是农药创制的热点之一. 按照不同的生物活性和结构进行分类, 对近年来肟类化合物在农业中应用作了综述, 着重从分子合成和生物活性进行讨论, 并对它的发展趋势、应用前景作了进一步展望.