γ-聚谷氨酸水凝胶的性质、制备及其应用

系统介绍了γ-聚谷氨酸水凝胶的制备方法及其生物可降解性、高吸水性及保湿性、pH敏感性、生物相容性和可修饰性等性能,同时综合介绍了其在组织工程、药物控释和创面修复等方面的应用,结合本研究组工作对其未来的发展进行了展望。     

Purification and Characterization of an Antibacterial Peptide from Rana Temporaria Chensinensis Skin

ＩｎｔｒｏｄｕｃｔｉｏｎＩｎａｄｄｉｔｉｏｎｔｏｔｈｅｈｉｇｈｌｙｓｐｅｃｉｆｉｃｃｅｌｌ－ｍｅｄｉａｔｅｄｉｍｍｕｎｅｓｙｓｔｅｍ，ｖｅｒｔｅｂｒａｔｅｓａｎｄｏｔｈｅｒｏｒｇａｎｉｓｍｓｈａｖｅａｄｅｆｅｎｓｅｓｙｓｔｅｍｍａｄｅｕｐｏｆｄｉｓｔｉｎｃｔｇｒｏｕｐｓｏｆｂｒｏａｄ－ｓｐｅｃｔｒｕｍａｎｔｉｂａｃｔｅｒｉａｌｐｅｐｔｉｄｅｓ［１—３］．Ａｎｔｉｂａｃｔｅｒｉａｌｐｅｐｔｉｄｅｓｃａｎｂｅｃｌａｓｓｉｆｉｅｄｉｎｔｏｔｗｏｇｒｏｕｐｓｂａｓｅｄｏｎｈａｖｉｎｇｄｉｓｕｌ－ｆｉｄｅ…     

Crystal and Molecular Structure of Copper(Ⅰ) Complex 〔Cu(PPh_3)_2(NO_3)〕

1　 INTRODUCTIONCopper( ) displays a wide diversity in its structural chemistry,the copper co-ordination number ranging from two to four.Procedures to synthesize copper( )complexes are of greatinterestbecause of the diversity of products resulting from al-mostthe same methodology.Ithaslong been accepted thatcopper( ) complexesarediamagnetic and provide no optical absorption bands( no d- d transition isencountered) for a copper( ) ion with a d10 configuration and no electron spin reso-n…     

Resolution of 3,3''''-Dioxo-1,1''''(3H,3(H)spirobi[isobenzofuran] -5,6,5''''6''''-tetracarboxylic acid and Optically active Polyimides thereof

Previously, we have reported a novel type of polyimides prepared from 3,3(-dioxo-1,1((3H,3(H)spirobi[isobenzofuran]-5,6,5(,6(-dianhydride 1a and a variety of diamines1. Considering that a spiral compound is planar asymmetry2, we recently studied the resolution of 1, and thereof, synthesized the optically active polyimides. To our knowledge, optically active polyimides containing a planar asymmetric monomers have not been reported thus far. Cinchonidine and cinchonine base were proved to be an…     

Mimetic Preparation of Analogues of Territrem B, A Potent Acetylcholinesterase Inhibitor

One of the strategies of bettering Alzheimer's Disease is focused on cholinergic compound based on the cholinergic hypothesis1. An important approach to cholinergic augmentation is administration of cholinesterase inhibitors such as Huperzine A2. Territrem B is a potent AChE inhibitor (IC50 47 nM, H. Zea AchE)3, and its inhibitory mechanism is totally different with the known AChE inhibitors4. In the last report we have described three routes of synthesizing Territrem B analogues, whic…     

Generation of 7-fs laser pulse directly from a compact Ti:sapphire laser with chirped mirrors

A compact femtosecond Ti:sapphire laser resonator consisting of three chirped mirrors and one output coupler was designed. By accurately balancing the intra- cavity dispersions between Ti:sapphire crystal, air and chirped mirrors, we directly generated the laser pulse shorter than 7 fs at the average power of 340 mW with 3.1 W pump. The repetition rate of the laser oscillator is 173 MHz at the centre wavelength of 791 nm, and the ultrabroaden spectrum covers from 600 nm to 1000 nm. To the best of our knowledge, this is the simplest laser resonator capable of generating sub-10 fs laser pulse.     

One-pot Synthesis of 1-Aryloxyacety l-4-(4''''-nitrophenyloxyacetyl)-thiosemicarbazides under Phase Transfer Catalysis and Microwave Irradiation

1,4-Disubstituted thiosemicarbazides have attracted much attention in recent years because of their fungicidal1-2, bactericidal3-4 and tuberculostatic5-6 activities. Meanwhile, aryloxy acetic acid derivatives have also been used as herbicides and plant-growth regulators7-10. These applications prompt us to develop a simple and rapid synthetic method to prepare a series of new compounds bearing both thiosemicarbazide and aryloxyacetyl moieties, with the object of obtaining new biologically ac…     

Synthesis and Nonlinear Optical Property of a Series of New Chromophores Containing Furan Ring as the Only Conjugation Bridge

This paper reports the synthesis and the nonlinear optical property of a series of new chromophores which contain furan ring as the only conjugation bridge for the first time. They are characterized by UV-VIS, FT-IR, 1H NMR, MS and elemental analysis. Their dipole moment and the first-order molecular hyperpolarizability (β) are calculated and compared with those of the analogues containing either benzene or thiophene as the conjugation bridge.