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551.
Antioxidative Effect of Schiff Bases with o-Hydroxybenzylidene Groupon Free Radical Induced Hemolysis of Human Red Blood Cell 总被引:1,自引:0,他引:1
LUO Xu yang ZHAO Jian zhang LIN Ying jie LIU Zai qun * College of Chemistry Jilin University Changchun P. R. China 《高等学校化学研究》2002,18(3):287-289
IntroductionThe recent development of free radical biologyand medicine has provided a great deal of clinicaland experimental evidence indicating that the freeradical induced peroxidation of membrane lipids isassociated with a variety of chronic healthproblems,such as cancer,atherosclerosis andageing[1,2 ] . Both natural and synthetic antioxidantshave been used to trap peroxyl radicals and/orinitiating radicals to protect the membrane lipidsagainst free radical chain reactions,and hence mayhave… 相似文献
552.
Synthesis and cytotoxic activity of novel curcumin analogues 总被引:3,自引:0,他引:3
Qin Zhang Yao Fu Hao Wei Wang Tao Gong Yong Qin Zhi Rong Zhang~* Key Laboratory of Drug Targeting Drug Delivery Systems Ministry of Education West China School of Pharmacy Sichuan University Chengdu China 《中国化学快报》2008,19(3):281-285
Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues (1A-1C, 1E) with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin. 相似文献
553.
甲醇是一个重要的平台分子, 实现其高效转化为能源和化学品的关键是揭示相关反应过程中催化剂的结构与催化性能之间的关系和反应机理. 围绕这个关键问题, 以甲醇选择氧化为探针反应, 本文总结了负载氧化钼、负载氧化钒和杂多酸等典型催化剂体系以及近年来发展的氧化铼、氧化钌等新催化剂体系在认识催化活性中心结构和反应机理, 进而调控它们的氧化中心和酸中心等方面所取得的进展. 这些认识将有助于设计制备性能优异的新催化剂和实现甲醇到目标氧化产物的定向转化. 相似文献
555.
Chun YANG * Key Lab of New Materials Technology of China National Packaging Corporation Zhuzhou Engineering College Zhuzhou College of Chemistry Environmental Science Nanjing Normal University Nanjing 《中国化学快报》2003,14(1):96-99
Recently, a novel method of modification, i.e., functionalizing the internal surface of mesoporous materials has been reported1-5, owing to the large pore size, the silanol groups, which are in a big population in mesoporous materials, can chemically couple with the active groups of some bulky organic functional molecules. Based on this approach, one can obtain novel solid basic catalysts. Here we functionalized the hexagonal and hexagonal-like mesoporous silica materials SBA-3 and HMS wi… 相似文献
556.
IntroductionFunctional polymers bearing chiral moietiesand the extended conjugatedπ system have attract-ed considerable attention during the pastdecade[1,2 ] .The enantiodifferation properties ofsuch macromolecules give rise to multiple applica-tions in the fields of asymmetric catalysis,chiralsensors,polarized light emission and nonlinear op-tical materials[3 ,4] .Especially the incorporation ofoptically active binaphthyls in the main chain ofconjugated polymers can lead to an efficient ands… 相似文献
557.
§1.IntroductionIn[5],MaliavinandNualartdefinedthenotionof(real)smoothmartingalesandwethenprovedin[6]thattheprocesofquasisureq... 相似文献
558.
Jin Wen WANG Yi Yuan PENG Cheng Xue ZHAO* Department of Chemistry Shanghai Jiaotong University Shanghai Department of Chemistry Jiangxi Normal University Nanchang 《中国化学快报》2002,13(8)
Because the solvent dependency of aN, g factors and line widths of some bulky and stable di-t-alkyl nitroxides1, ESR has been proved to be a useful tool in searching for the nature of medium effects ( solvation ) to chemical reactivity. A large number of fluorinated nitroxides with a wide variety of structures have been generated and subjected to extensive studies in our laboratory2. Amongst, t-butyl perfluoroalkyl nitroxides, much less hindered, with noβ-H atoms, have been employed as sp… 相似文献
559.
Jiu Yu LIU Hui Yuan GUO* Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Peking Union Medical College Beijing 《中国化学快报》2004,15(5)
Quinolone antibacterial agents have emerged as one of the dominant classes chemotherapeutic drugs for the treatment of various bacterial infections1. We have focused our attention on the modification of the C-7 basic group of the quinolone which has been most varied. In 1987, Uno et al.2 reported that 3-hydroxypyrrolidine quinolones showed more active antibacterial activities than Norfloxacin in vivo. In 1998, Fujita et al.3 reported that 2-aminomethylpyrrolidine quinolones have the same … 相似文献
560.
Ke Qiang DING Zhen Bin JIA Qing Fei WANG Juan BAI Ru Ting TONG Xin Kui WANG Hui Bo SHAO* Institute of Coal Chemistry Chinese Academy of Science Taiyuan Department of Chemistry Hebei Teachers University Shijiazhuang D 《中国化学快报》2002,13(4)
Recently, the adsorption behavior of protein on solid substrate has attracted much attention for the reason that adsorption on a substrate is the first key step for other further electrochemical investigation1. Meanwhile the free adsorption could provide a relative well-ordered structure, with which some fundamental study could be carried out conveniently2. As we know, the electrochemical impedance spectroscopy (EIS) method has become one of the powerful techniques to detect the change of i… 相似文献