In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition

Nicotine, 3-(1-methyl-2-pyrrolidinyl)pyridine, the main alkaloid in tobacco products, has been well known for its addiction effect. Habitual smokers are usually maintaining nicotine concentration constant in their blood at about 10-15 ng/mL1. Therefore the interaction of nicotine and hemoglobin (Hb) is essential to be studied. Our recent study by accelerator mass spectrometry (AMS) has shown that nicotine could form adducts with Hb after in vivo administration, and there is a positive dose r…     

Preparation and Properties of Oxidized Graphite Anode Doped with Metal Ion for Lithium Ion Batteries

During the past years, there have been a lot of interests in the research of carbonaceous material as anode in lithium ion batteries1-3. Among them, natural graphite seems to be the most promising candidate for anode in lithium-ion batteries in terms of economy. Figure 1 The effect of Different Contents Figure 2 The Effect of Reacting Timeof Mixed Acid on Interlayer Distance On Interlayer DistanceHowever the raw natural graphite cannot be used for commercial purposes, because during proc…     

钇和柠檬酸对非负载磷化镍催化剂加氢脱硫性能的影响

采用传统程序升温(TPR)法制备了稀土金属钇(Y)或柠檬酸(CA)改性及Y和CA同时改性的非负载型Ni2P催化剂;采用X射线衍射(XRD)分析、N2吸附比表面积(BET)测定、CO化学吸附分析、X射线光电子能谱(XPS)和透射电子显微镜(TEM)对催化剂的结构和性质进行了表征;并考察了Y和CA对催化剂上进行的二苯并噻吩(DBT)加氢脱硫(HDS)反应性能的影响.结果表明,Y和CA均可促使非晶相NixPyOz向磷化镍活性相的转化,抑制Ni_5P_4杂晶相的形成,从而促进Ni2P活性相的生成;同时能够丰富催化剂的孔道,抑制催化剂表面磷的富集,得到更好的孔结构、更高的活性相分散度.Y或CA以及两者同时改性后的催化剂DBT转化率均明显高于Ni-P催化剂.各催化剂的HDS活性大小顺序为Y-Ni-P-CANi-P-CAY-Ni-PNi-P.在340℃,3.0 MPa,氢油体积比700,质量空速(WHSV)1.5 h-1的条件下,Y-Ni-P-CA催化剂的DBT转化率为97%,比Ni-P催化剂提高了约35%.     

Spherical foam growth in Al alloy melt

The ultra light metal structure, realizing the light-ness and multifunction of structural material, has a bright future in high-tech and civil fields and is be-coming one of the hotspots in developed countries in 21 century[1―8]. Preparing Al foam by mel…     

Effects of Anions and Cations on π-Complexation Between Olefin and Metal Halide

Introduction Separation,recoveryofolefinorremovalof tracequantitiesofolefinfromitsmixturesbyusing π-complexatonisamostpromisingsolution,com- paredwithenergy-intensivedistillationorotheral- ternatives.π-Complexationisasubgroupofchemi- calcomplexationwhereamixtureisbroughtinto contactwithasecondphasecontainingacomplex- ingagent[1].Forexample,theadsorbentscontain- ingAg+orCu+canselectivelyadsorbolefinfroman ethylene/ethaneorpropylene/propanemixture. Becausetheπ-complexationbondsarestronger th…     

Hydrothermal Synthesis of Pb_(1-1.5x)La_xZr_(0.5)Ti_(0.5)O_3 (x = 0.01-0.06) Nanocrystallites

Lanthanum doped lead zirconate titanate (PLZT) ceramics display excellent electrooptic and photostriction properties because of the existence of cavities in the perovskite structure1-3. The PLZT powders are conventionally prepared by solid state reaction4-5, and the wet chemical methods such as sol-gel techniques are then introduced6-7. However, the homogeneity, morphology and size of the particles, which greatly affect the sinterability and the property of the resulting ceramics, are dif…     

Theoretical Study on Intramolecular Proton Transfer of Perylenequinonoid Derivatives

In the past two decades, perylenequinonoid derivatives (PQD), such as hypocrellin A (HA), hypocrellin B (HB) and hypericin (HYP) have attracted considerable attention owing to their excellent properties of photosensitization and great advantages over the investigation of intramolecular proton transfer (IPT)1-5. Previous researches demonstrated that IPT both in the ground state and excited states exists in PQD and is critical for PQD to reserve their photosensitive activity3,6. Altho…     

Design,synthesis and antifungal activities in vitro of novel tetralin compounds

Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhihitars of fungi.     

基于滚动计划的动态企业资源优化模型

由于传统MRP逻辑存在固有的缺陷,ERP系统中的生产计划模块往往不能满足企业快速发展的需要。为此,文章提出了一个可以实时推进的,能够实现企业资源优化配置的新型企业资源规划系统。系统的核心是一个基于滚动计划的动态企业资源优化模型。文章讨论了将滚动周期理论引入企业资源优化模型的方法和优势。基于该模型的新系统构建更加灵活,应用范围更加广阔,生成的生产计划更加符合企业生产实际。