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991.
992.
The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs) that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates. 相似文献
993.
A range of 3H-indoles and 2H-benzo[b][1,4]thiazines smoothly undergo asymmetric Strecker reaction with ethyl cyanoformate in the presence of a Cinchona alkaloid-based thiourea catalyst at 10 °C to give structurally diverse nitrogen-containing heterocycles in good to excellent yields and with excellent ee. 相似文献
994.
Chen L Tan K Lan YQ Li SL Shao KZ Su ZM 《Chemical communications (Cambridge, England)》2012,48(47):5919-5921
Two isostructural 2D → 2D parallel → 3D inclined interpenetrating polycatenane-like metal-organic frameworks were successfully constructed based on length-adjusted tricarboxylate ligands. With the merit of being microporous, IFMC-10 can serve as host for encapsulating lanthanide cations and I(2) to exhibit luminescent sensing and rapid adsorption of iodine. 相似文献
995.
Na Z Li L Uttamchandani M Yao SQ 《Chemical communications (Cambridge, England)》2012,48(58):7304-7306
A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy. 相似文献
996.
Huang P Qin C Wang XL Sun CY Yang GS Shao KZ Jiao YQ Zhou K Su ZM 《Chemical communications (Cambridge, England)》2012,48(1):103-105
An unprecedented organic-inorganic hybrid {[Cu(6)L(6)(H(2)O)(3)][Nb(10)V(4)O(40)(OH)(2)]}(2)·13H(2)O (1) (L = 1,10-phenanthroline) containing the unreported {Nb(10)V(4)O(40)(OH)(2)}(12-) building blocks has been successfully synthesized and its photoluminescent properties, IR spectra, thermogravimetric analyses and single-crystal X-ray diffraction were investigated. 相似文献
997.
A library of 176 human phosphotyrosine-containing peptides was used to establish cell lysate binding profiles in a two colour microarray format. The resulting hits led to the pull-down and identification of biomarkers associated with cancer states. 相似文献
998.
The rate of heat output is one of the suitable measurements of metabolic activity of the organism. In this article, microcalorimetry
was first applied to study the effect of volatile oil of dry ginger (ginger oil) on Escherichia coli and Staphylococcus aureus growth. The power–time curves were plotted with a TAM air isothermal microcalorimeter. The parameters such as the growth
rate constant μ, the peak-time T
p, inhibitory ratio I, and half-inhibitory concentration IC50 were calculated. From the data, the relationships between μ and the concentration of ginger oil c were established. The results revealed that the μ of E. coli and S. aureus both gradually declined with the increase of the c, there were linear relationships between μ and c, and ginger oil had stronger inhibitory effect on S. aureus than on E. coli. Results obtained from our study strongly suggest that microcalorimetry is an ideal method to investigate the effect of drug
on microorganism. 相似文献
999.
Yubo ChenDengjie Chen Ran RanHee Jung Park Chan KwakSung Jin Ahn Kyeong Suk MoonZongping Shao 《Electrochemistry communications》2012,14(1):36-38
Nickel oxide was introduced as a grain growth inhibitor into Ba0.5Sr0.5Co0.8Fe0.2O3 − δ (BSCF) electrode to increase its activity for oxygen reduction reaction. Small amount of NiO can effectively suppress the grain growth of BSCF by spinning the grain boundary and thus increase the electrode surface area, while the particle connection is not obviously affected. Electrochemical impedance spectra of symmetric cells indicate that the electrode activity for oxygen reduction is indeed effectively improved by introducing NiO additive. At 600 °C, area specific resistance of BSCF+5wt.% NiO is about 36.5% lower than that of pure BSCF electrode. Single cell tests also demonstrate an improved cell power output by introducing NiO additive. It implies that the adoption of a sintering inhibitor may be a facile and practical way to increase electrode activity for oxygen reduction. 相似文献
1000.
We report herein a well-defined NHC–Pd(II)–Im (NHC=N-heterocyclic carbene; Im=1-methylimidazole) complex catalyzed C–N coupling of primary amines with aryl chlorides. Under the optimal reaction conditions, a variety of primary amines can be coupled with aryl chlorides to give the amination products in good to high yields within 4 h. It is worthy of noting here that the NHC–Pd(II)–Im complex showed especially high catalytic activity toward challenging sterically hindered substrates including both of aryl amines and aryl chlorides. In addition, alkyl amines were also proved to be suitable reaction partners to give the corresponding amination products in good to high yields. 相似文献