全文获取类型
收费全文 | 319篇 |
免费 | 7篇 |
国内免费 | 2篇 |
专业分类
化学 | 182篇 |
晶体学 | 5篇 |
力学 | 4篇 |
数学 | 67篇 |
物理学 | 70篇 |
出版年
2023年 | 4篇 |
2022年 | 2篇 |
2021年 | 5篇 |
2020年 | 8篇 |
2019年 | 8篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 5篇 |
2015年 | 11篇 |
2014年 | 10篇 |
2013年 | 12篇 |
2012年 | 18篇 |
2011年 | 31篇 |
2010年 | 12篇 |
2009年 | 7篇 |
2008年 | 19篇 |
2007年 | 20篇 |
2006年 | 14篇 |
2005年 | 8篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 10篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1981年 | 3篇 |
1975年 | 3篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1967年 | 2篇 |
1959年 | 3篇 |
1958年 | 3篇 |
1956年 | 5篇 |
1948年 | 3篇 |
1947年 | 5篇 |
1946年 | 4篇 |
1944年 | 2篇 |
排序方式: 共有328条查询结果,搜索用时 15 毫秒
91.
Suhanya Parthasarathy Surash Ramanathan Sabariah Ismail Mohd Ilham Adenan Sharif Mahsufi Mansor Vikneswaran Murugaiyah 《Analytical and bioanalytical chemistry》2010,397(5):2023-2030
A new solid phase extraction method for rapid high performance liquid chromatography–UV determination of mitragynine in plasma has been developed. Optimal separation was achieved with an isocratic mobile phase consisting of acetonitrile–ammonium acetate buffer, 50 mM at pH 5.0 (50:50, v/v). The method had limits of detection and quantification of 0.025 and 0.050 μg/mL, respectively. The method was accurate and precise for the quantitative analysis of mitragynine in human and rat plasma with within-day and between-day accuracies between 84.0 and 109.6%, and their precision values were between 1.7 and 16.8%. Additional advantages over known methods are related to the solid phase extraction technique for sample preparation which yields a clean chromatogram, a short total analysis time, requires a smaller amount of plasma samples and has good assay sensitivity for bioanalytical application. The method was successfully applied in pharmacokinetic and stability studies of mitragynine. In the present study, mitragynine was found to be fairly stable during storage and sample preparation. The present study showed for the first time the detailed pharmacokinetic profiles of mitragynine. Following intravenous administration, mitragynine demonstrated a biphasic elimination from plasma. Oral absorption of the drug was slow, prolonged and was incomplete, with a calculated absolute oral bioavailability value of 3.03%. The variations observed in previous pharmacokinetic studies after oral administration of mitragynine could be attributed to its poor bioavailability rather than to the differences in assay method, metabolic saturation or mitragynine dose. 相似文献
92.
The three-dimensional sponge-like mesoporous material TUD-1 is straightforward to prepare. Its synthesis can readily be modified to introduce metals into the framework of TUD-1, imparting many different catalytic activities. M-TUD-1 catalysts have proven to be very active, unlimited by diffusion and very stable. By combining two metals into one TUD-1 catalyst, synergy between Lewis and Br?nsted acid sites could be induced; incorporation of zeolites similarly gave rise to synergy. In addition to successful applications in redox-, acid- and photo-catalysis TUD-1 proved to be an excellent carrier material for catalysts, enabling new applications. TUD-1 was used as a contrast agent and drug delivery system, indicating that this material is but at the beginning of its potential applications. 相似文献
93.
94.
Single scan longitudinal relaxation measurement experiments enable rapid estimation of the spin‐lattice relaxation time (T1) as the time series of spin relaxation is encoded spatially in the sample at different slices resulting in an order of magnitude saving in time. We consider here a single scan inversion recovery pulse sequence that incorporates a gradient echo sequence. The proposed pulse sequence provides spectra with significantly enhanced signal to noise ratio leading to an accurate estimation of T1 values. The method is applicable for measuring a range of T1 values, thus indicating the possibility of routine use of the method for several systems. A comparative study of different single scan methods currently available is presented, and the advantage of the proposed sequence is highlighted. The possibility of the use of the method for the study of cross‐correlation effects for the case of fluorine in a single shot is also demonstrated. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
95.
96.
Shriram P. Kotkar 《Tetrahedron letters》2006,47(38):6813-6815
An efficient enantioselective synthesis of a new antiepileptic drug, levetiracetam is described, in high optical purity (>99.5% ee), using proline-catalyzed α-aminooxylation of n-butyraldehyde as the key step. 相似文献
97.
K. G. Ramanathan 《Proceedings Mathematical Sciences》1984,93(2-3):67-77
In the “Lost” note book, Ramanujan had stated a large number of results regarding evaluation of his continued fraction
for certain values of τ. It is shown that all these results and many more have their source in the Kronecker limit formula. 相似文献
98.
In this paper, a novel strategy for multicomponent analysis of two classes of pesticides such as triazines (atrazine and simazine) and phenoxyalkanoic acids (2,4-dichlorophenoxy acetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 4-chlorophenoxyacetic acid (CPOAc), phenoxyacetic acid (POAc)) employing immuno-arrays is demonstrated. The approach is based on cross-reactive arrays of specific antibody pairs coupled to chemometric pattern recognition. The monoclonal antibody pairs employed in this work (atrazine-simazine and 2,4-D) are specific towards a set of analytes and preclude a particular set of others present in the sample matrix. Antibody pairs of atrazine, simazine, and 2,4-D are used to discriminate and quantify analyte of interest. Atrazine was quantified in presence of trace concentration of simazine and that of 2,4-D. The combinatorial cross-reactivity of antibody pairs towards simazine, atrazine and 2,4-D is used to distinguish among different classes of analytes and their influence on the signal suppression in immuno-techniques. These sensors exclude recognition by carbamates such as carbaryl and carbofuran. 相似文献
99.
P. Judeinstein P. Berdagué J.-P. Bayle Neeraj Sinha K. V. Ramanathan 《Liquid crystals》2013,40(11):1691-1698
Short terminal polyoxyethylene chains may be introduced into mesogens containing lateral substituents such as two hexyloxy chains or a crown-ether fragment. These compounds have a large nematic range near room temperature and can dissolve large amounts of the salt LiBF4 without destroying the nematic arrangment. In the nematic phase, the ions are ordered and the quadrupolar splitting associated with these ions can allow this ordering to be monitored. Increasing the salt concentration does not seem to change the ordering of the individual ions. The 13C thermal evolution of the field-induced chemical shift in the oxyethylene (OE) units with or without salt does not show any real difference, indicating that the interaction between the ions and the mesogen is small. This means that there is very little change in conformation in the OE unit when adding salt to the mesogen. 相似文献
100.