Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation

Lycium barbarum leaves are a kind of vegetable, and modern nutrition studies have found that they have an anti-aging function. Our study aims to investigate the anti-aging effects of Lycium barbarum leaf flavonoid (LBLF) extracts and its underlying molecular mechanism. LBLFs were purified using D101 and polyamide resin, characterized by ultraperformance liquid chromatography coupled with mass spectrometry, and administered to hydrogen peroxide (H₂O₂)-treated human umbilical vein endothelial cells (HUVECs) and Caenorhabditis elegans. Appropriate enrichment conditions were optimized through dynamic adsorption and desorption experiments, the content of flavonoids reached 909.84 mg/g, rutin and kaempferol being the main ones. LBLFs attenuated H₂O₂-induced HUVEC apoptosis, decreased reactive oxygen species and malondialdehyde production levels, increased superoxide dismutase, glutathione peroxidase and catalase activities. Furthermore, pre-treatment with LBLF increased mRNA expression of erythropoietin (EPO) and heme oxygenase-1 (HO-1) via the mitogen-activated protein kinase (MAPK) signaling pathway in HUVECs. Compared with 100 µM rutin monomer, LBLF prolonged the lifespan of Caenorhabditis elegans, enhanced their mobility in middle life stages and upregulated expression of sod-2, gcs-1 and skn-1 genes, which indicated that the anti-aging effects of LBLF were due to its redox-modulation.     

α-氨基膦酸酯的合成方法研究进展

从Lewis催化剂合成法、非Lewis催化剂合成法、绿色合成法3个方面综述了近年来国内外在α-氨基膦酸酯合成研究领域的最新进展.参考文献33篇.     

低温等离子体数值模拟方法的分析比较

分析比较了低温等离子体模拟中采用的流体模型、粒子模型和混合模拟方法及在放电特性分析中采用的电路模拟方法。给出了每种方法的基本原理,探讨了它们的适应性。利用粒子模型对外磁镜场作用下四阳极装置辉光放电所产生等离子体进行了模拟,分析了磁场对电子密度径向分布的影响。     

磷酸氯喹的流动注射逆胶束介导化学发光法测定

在酸性条件下,磷酸氯喹分子中氮原子被质子化后与阴离子AuCl4-形成离子缔合物,该缔合物被二氯甲烷带入鲁米诺的氯化十六烷基三甲基铵逆胶束中,离解出来的AuCl4-立即与鲁米诺产生化学发光.在一定的浓度范围内,发光强度与磷酸氯喹的含量呈线性关系,从而间接测定磷酸氯喹的含量.在优化的实验条件下,线性范围为0.001～15 mg/L,检出限(3σ)为0.02 μg/L,对1.0 mg/L的磷酸氯喹进行11次平行测定,RSD为1.6%.该法已成功用于片剂的分析.     

菲涅耳-基尔霍夫积分与半波带法分析衍射光谱

惠更斯菲 涅耳原理指出光的衍射本质是无穷多次波的相干叠加.在研究衍射光谱的强度时可使用菲涅耳-基尔霍夫衍射积分进行计算,但该积分的计算较为复杂.为了简化计算而引入菲涅耳半波带的概念,把积分运算简化为振幅矢量的叠加,从而在研究衍射时由菲涅耳-基尔霍夫衍射积分过渡到菲涅耳半波带法.在菲涅耳半波带法中波前上相邻两个半波带到达叠加点的光程差为半个波长,从而导致相位差π.因此相邻两个半波带引起的振动在叠加点发生相消,最终叠加点的光强由发出次波的半波带数目的奇偶性决定.奇数个半波带在叠加点的光强得到加强,偶数个半波带在叠加点的光强发生相消.     

逆Walsh序p值Walsh变换的演化生成及快速算法

本文利用二分演化思想和矩阵分解技术 ,重点讨论逆Walsh序三值Walsh变换的演化生成和快速算法 ,并将之推广至p值情形 .     

Non-commutative Chiral QCD2 Model

The effective action of chiral QCD₂ was studied in two-dimensional non-commutative space-time by using path integral approach. It is shown that vector boson has a mass generation and the effective Lagrangian contains a term corresponding to a Wess-Zumino-Witten-like term.     

对流扩散方程的稳定化流线扩散法最小二乘非协调有限元分析

将最小二乘法和稳定化的流线扩散法相结合,研究了对流扩散方程的非协调有限元格式,用矩形EQ_1~(rot)元和零阶R-T元分别来逼近位移和应力,利用单元本身的特殊性质,证明了离散格式解的存在惟一性,得到了位移H~1-模和应力H(div)-模的最优误差估计.