A comprehensive exploration of pharmacological properties,bioactivities and inhibitory potentiality of luteolin from Tridax procumbens as anticancer drug by in-silico approach

Structural Chemistry - Tridax procumbens is a flowering plant of the Asteraceae family with a wide range of medicinal uses like anti-inflammatory, anti-diabetic, anti-microbial, immunomodulatory,...     

Bianchi Type-III Cosmological Models with Time Dependent Displacement Vector for Barotropic Fluid Distribution in Lyra Geometry

Bianchi Type-III cosmological models for perfect fluid distribution with time dependent displacement field in the framework of Lyra geometry are investigated. To get the deterministic model of the universe, we have assumed two conditions (i) shear (σ) is proportional to the expansion (θ). This leads to B=C ⁿ where B and C are metric potentials and n is a constant. (ii) Universe is filled with barotropic fluid distribution which leads to p=γ ρ, 0≤γ≤1, p being isotropic pressure and ρ the energy density. The physical and geometrical aspects of the model with a special case and singularities in the models are also discussed.     

T-duality for string in Hořava–Lifshitz gravity

We continue our study of the Lorentz-breaking string theories. These theories are defined as string theory with modified Hamiltonian constraint which breaks the Lorentz symmetry of target space-time. We analyze the properties of this theory in the target space-time that possesses isometry along one direction. We also derive the T-duality rules for Lorentz-breaking string theories and show that they are the same as that of Buscher’s T-duality for the relativistic strings.     

Electron Ionization Mass Spectra of Organophosphorus Compounds. Part III: Mass Spectrometric Fragmentation of Diethyl Spiro[Pyrimidino[5,3′][1,2]Oxazole] Phosphonate,Diethyl (Oxazolo[5,4-D]Pyrimidine-4,6-Dione)Phosphonate,and Diethyl (Pyrimidino[4,5-B][1,4]Oxazine)Phosphonate Derivatives

Abstract

Fragmentation pathways of 14 organophosphorus compounds derived from diethyl spiro[pyrimidino[5,3][1,2]oxazole] phosphonates, diethyl (oxazolo[5,4-d]pyrimidine-4,6-dione)phosphonates, and diethyl (pyrimidino[4,5-b][1,4] oxazine)phosphonates were investigated by electron impact mass spectrometry (EI-MS). The intensity of the recorded molecular ion peaks showed various values depending on the nature of the compounds. Characteristic fragment ions were formed by successive loss of simple functional groups followed by decomposition of heterocycles connected to pyrimidine rings.     

The One Step Synthesis of 2-(2-Bromo-5- methoxyphenyl)-5-(3-arylidene)-1,3-thiazolo[3,2-b]- 1,2,4-triazol-6-(5H)-ones and the Evaluation of the Anticonvulsant Activity

A smooth one-step synthesis of 2-(2-bromo-5-methoxyphenyl)-5-(3-arylidene)-1,3-thiazolo[3,2-b]-1,2,4-triazol-6-(5H)-ones (4a–n) is described. The newly prepared compounds are characterized by analytical and IR, ¹ H NMR, ¹³ C NMR, and FABMS spectral analysis. A few compounds are screened for anticonvulsant activity. Compounds 4i and 4n exhibit promising anticonvulsant activity and are recommended for further studies.