Acid-mediated domino reaction of ortho-carbonylated alkynyl-substituted arylaldehydes with phenols: Rapid access to fused indeno[2,1-c]chromen-7-one derivatives

Acid-mediated domino reaction of ortho-carbonylated alkynyl-substituted arylaldehydes with phenols is described. The implement of this reaction can provide directly a variety of tetracyclic indeno[2,1-c]chromen-7-one products in good yields. The mechanism was proposed to be a domino indanone ring formation/ortho-alkylation of phenols/dehydrated cyclization for the formation of polycyclic skeleton. In addition, several interesting dimeric products containing a pentacyclic scaffold were also afforded stereoselectively albeit in moderate yields. The present transformations feature the use of simple acid catalyst, short reaction time and good substrate scope.     

Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water

A one-pot, three-component condensation reaction of 8-quinolinol, 2-thiobarbituric acid and isatins or aldehydes in water to give novel barbituroquinoline derivatives for the first time, is described. The reaction is free of catalysts and toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations.     

Bienzyme-based visual and spectrophotometric aptamer assay for quantitation of nanomolar levels of mercury(II)

The article describes a bienzyme visual system for aptamer-based assay of Hg(II) at nanomolar levels. The detection scheme is based on the finding that Hg(II) ions captured by aptamer-functionalized magnetic beads are capable of inhibiting the enzymatic activity of uricase and thus affect the formation of H₂O₂ and the blue product, i.e., oxidized tetramethylbenzidine. This strategy allows for a visual detection of Hg(II) at nanomolar levels without additional amplification procedure. Measuring the absorbance at 650 nm, the logarithmic calibration plot is linear in the concentration range of 0.5–50 nM and the limit of detection (LOD) is 0.15 nM. This is as low as the LOD obtained by atomic fluorescence spectrometry (AFS). The ions K⁺, Mg²⁺, Na⁺, Ca²⁺, Cu²⁺, Zn²⁺, Fe³⁺, Al³⁺, Co²⁺, AsO₂ ^?, Ni²⁺, Cd²⁺ and Pb²⁺ do not have a significant effect on color formation. The method was applied to the analysis of (spiked) river water, lake water, mineral water, tap water and certified reference water samples, and the results agreed well with those obtained by AFS or certified values, with recoveries ranging from 97% to 109%. The relative standard deviation for five parallel detections at a 10 nM Hg(II) level is 5.2%.

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Graphical abstract A bienzyme-based visual aptasensor was fabricated for label-free detection of nanomolar Hg²⁺ in water samples without any amplification or enrichment procedure.

     

Synthesis and characterization of tetraoctyloxy substituted naphthalenophanedienes

Tetraoctyloxy-substituted naphthalenophanedienes were synthesized from tetraoctyloxy-substituted dithia[3.3]naphthalenophanes via sequential benzyne Stevens rearrangement, oxidation, and pyrolysis reactions. Surprisingly, only the pseudo-geminal isomer of tetraoctyloxy-substituted dithia[3.3]naphthalenophane was obtained after cyclization of the corresponding starting materials. The structures of the pseudo-geminal isomers of tetraoctyloxy-substituted dithia[3.3]naphthalenophane and tetraoctyloxy-substituted naphthalenophanediene were fully determined by nuclear magnetic resonance spectroscopy, high resolution mass spectrometry, and X-ray crystallography. The pseudo-geminal and pseudo-meta diastereomers of tetraoctyloxy-substituted naphthalenophanedienes were isolated by multiple fractional recrystallization from hexane at 5 °C. The solid state structure of the pseudo-geminal isomer of tetraoctyloxy-substituted naphthalenophanediene revealed strongly distorted naphthyl rings with high levels of ring strain.     

Recent Progress of Synthesis and Application in Au@MOFs Hybrid Materials

The combination of gold nanoparticles and metal–organic frameworks is one of the new directions of current research. It has applications in many aspects, especially as a catalyst for a variety of reactions. Therefore, this paper describes recent progress of synthesis and application in Au@MOFs hybrid materials.     

Encapsulation of RNA by negatively charged human serum albumin via physical interactions

Human serum albumin (HSA) is the most abundant plasma protein and has an inherent ability to target tumor cells. It is an excellent candidate for drug delivery. However, HSA cannot form complex with DNA or RNA, because it is negatively charged under physiological conditions. In this work, we reported a simple method to prepare HSA/RNA nanoparticles mainly by physical interaction. Firstly, the solution pH is adjusted to 4.0, under which condition HSA is positively charged. It forms complex with RNA via electrostatic interaction. The solution is then heated at 75 oC for 15 min to stabilize the structure and the size of the formed complex. The HSA/RNA nanoparticle prepared by this method has a diameter about 110 nm and a narrow distribution. It is also stable for days under physiological conditions. Cellular essays demonstrate that these particles exhibit a high cellular uptake efficiency and non-toxicity to HeLa cells.     

Lanthanide-organic frameworks based on terphenyl-tetracarboxylate ligands: syntheses,structures, optical properties and selective sensing of nitro explosives

Three isostructural three-dimensional(3D) lanthanide-based metal-organic frameworks [Ln_2L(H_2L)(NMP)_2].H_2O(Ln=Sm(1), Eu(2), Gd(3); H_4L=1,1′:4′,1″-terphenyl-2′,4,4″,5′-tetracarboxylic acid; NMP=N-methyl-2-pyrrolidone) have been synthesized and structurally characterized. In 1–3, two Ln3+ ions are doubly-bridged by two oxygen atoms of two carboxylate groups to form the dinuclear Ln_2(OCOO–)_2 unit. Each Ln_2(OCOO–)_2 unit links with four H_2L~(2-) ligands and four L4. ligands to lead to the 3D framework,which can be rationalized as a new trinodal 4,4,8-connected(44.62)(45.6)(412.616) topological network by considering the dinuclear Ln_2(OCOO–)_2 units as 8-connected nodes and L~4./H_2L~(2-) ligands as planar 4-connected nodes, respectively. 1 and 3 exhibit blue emission originated from the ligand with the emission maximum at 384 nm, while 2 shows intense characteristic red emission of Eu~(3+) ions and weak ligand-centered emission. Moreover, 2 has fluorescent quenching response towards the aromatic nitro compounds, especially for the 3,4-dinitrotoluene(3,4-DNT) with the linear Stern-Volmer relationship in the concentration range of 0–1 mM and the quenching constant(Ksv) of 2.084×10~3 M~(-1).     

On the proof of Erdős’ inequality

Using undergraduate calculus, we give a direct elementary proof of a sharp Markov-type inequality \({\left\| {p'} \right\|_{\left[ { - 1,1} \right]}} \leqslant \frac{1}{2}{\left\| p \right\|_{\left[ { - 1,1} \right]}}\) for a constrained polynomial p of degree at most n, initially claimed by P. Erd?s, which is different from the one in the paper of T.Erdélyi (2015). Whereafter, we give the situations on which the equality holds. On the basis of this inequality, we study the monotone polynomial which has only real zeros all but one outside of the interval (?1, 1) and establish a new asymptotically sharp inequality.     

Some evaluation of q-analogues of Euler sums

In this paper, we discuss the analytic representations of q-Euler sums which involve q-harmonic numbers through q-polylogarithms, either linearly or nonlinearly, and give explicit formulae for several classes of q-Euler sums in terms of q-polylogarithms and q-special functions. Furthermore, we develop new closed form representations of sums of quadratic and cubic parametric q-Euler sums. Finally, we can find that the q-Euler sums are reducible to the classical Euler sums when q approaches 1.     

Spectrality of infinite convolutions with three-element digit sets

Let \(0< \rho <1\) and let \(\{a_n, b_n\}_{n=1}^\infty \) be a sequence of integers with bounded from upper and lower. Associated with them there exists a unique Borel probability measure \(\mu _{\rho , \{0, a_n, b_n\}}\) generated by the following infinite convolution product

$$\begin{aligned} \mu _{\rho , \{0, a_n, b_n\}}=\delta _{\rho \{0, a_1, b_1\}} *\delta _{\rho ^2 \{0, a_2, b_2\}} *\delta _{\rho ^3 \{0, a_3, b_3\}} *\cdots \end{aligned}$$

in the weak convergence, where \(\delta _E=\frac{1}{\# E}\sum _{e \in E} \delta _e\) and \(\hbox {gcd}(a_n, b_n)=1\) for all \(n \in {{\mathbb {N}}}\). In this paper, we show that \(L^2(\mu _{\rho , \{0, a_n, b_n\}})\) admits an exponential orthonormal basis if and only if \(\rho ^{-1} \in 3{{\mathbb {N}}}\) and  \(\{a_n, b_n\} \equiv \{1, 2\} \ (\mathrm {mod} \ 3)\) for all \(n \in {{\mathbb {N}}}\).